Anti-TWIK-2 Antibody Biotin Conjugate (N469/28)

Name: Anti-TWIK-2 Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-463-BTN
Price: 543.0 USD
Availability: InStock

Our mouse TWIK-2 biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone N469/28. It detects mouse TWIK-2 and is purified by Protein A chromatography. Works in ELISA, ICC, WB.

Anti-TWIK-2 Antibody Biotin Conjugate

Click on image to zoom

Species Reactivity

Mouse

Applications

ELISA, ICC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

Go to Full Product Details

Data Sheet

SKU: 75-463-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

TWIK-2

Scientific Background

Potassium two pore domain channel subfamily K member 6 is encoded by the gene KCNK6. KCNK6 is a member of the two pore domain potassium channel (TC 1.A.1.8) family. KCNK6 is considered an open rectifier, and is stimulated by arachidonic acid and inhibited by internal acidification and volatile anaesthetics. KCNK6 is expressed in platelets and testis. Diseases associated with KCNK6 include Thoracic Outlet Syndrome and Gingival Recession.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N469/28

Isotype

IgG1

Applications

ELISA, ICC, WB

Host Species

Mouse

Gene Name

Kcnk6

Molecular Weight

35 kDa

Immunogen

Fusion Protein Amino acids 28-92 (first extracellular loop) of mouse TWIK-2 (accession number Q3TBV4) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Mouse

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

D7Ertd764e; TWIK-2; Twik2; Potassium channel subfamily K member 6; Inward rectifying potassium channel proteinTWIK-2; TWIK-2 two-pore-domain K+ channel; TWIK-originated similarity sequence

UniProt ID

Q3TBV4
UniProt Summary: K(+) channel that conducts outward rectifying currents at the membranes of the endolysosomal system. Active in lysosomes where it regulates lysosome numbers and size. In macrophages, enables K(+) efflux coupled to ATP-induced NLRP3 inflammasome activation upon bacterial infection. Cooperates with ATP-gated P2RX7 to activate NLRP3 inflammasome, with P2RX7 conducting Ca(2+) and Na(+) influx that sets the membrane potential for K(+) efflux.

NCBI Gene ID

52150

Shipping

Shipped on ice packs

Recover password

Create my account

Anti-TWIK-2 Antibody Biotin Conjugate (N469/28)

SKU: 75-463-BTN

Product Details

Bulk Order Anti-TWIK-2 Antibody Biotin Conjugate

Related Products

Recently Viewed