Featured Citations
Machine learning prediction of prime editing efficiency across diverse chromatin contexts.
Mathis N, et.al. Nature Biotechnology. 2024 Jun. 21. Epub ahead of print.
PMID: 38907037
Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice.
Yu L, et al. Nature Communications. 2023 Jul 25;14(1):4101. PMID: 37491347
FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress.
Kobiita A, et.al. Cell Reports. 2023 Aug 29;42(8):112986. PMID: 37590136
Citations By Research Area
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Bone
Collagen | ||
PMID | Publication | |
27468832 | Chen Y, et al. 2016. Bone morphogenetic protein 2 stimulates chondrogenesis of equine synovial membrane-derived progenitor cells. Veterinary and Comparative Orthopaedics and Traumatology, 378-385. | |
26414599 | Lipner Justin, et al. 2015. In Vivo Evaluation of Adipose-Derived Stromal Cells Delivered with a Nanofiber Scaffold for Tendon-to-Bone Repair. Tissue Engineering. Part A, 2766-2774. |
Osteoarthritis | ||
PMID | Publication | |
32647171 | M Arra, et al. 2020. LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis. Nature Communications, 3427. |
Osteogenesis | ||
PMID | Publication | |
29310783 | Kirby, D.J., et al. 2018. Isolation, production, and analysis of small leucine-rich proteoglycans in bone. Methods in Cell Biology, 281-296. | |
27734388 | Maeda A, et al. 2017. Analysis of CCN4 Function in Osteogenic and Osteoclastic Cells Using Gain and Loss of Function Approaches. Methods of Molecular Biology, 347-359. | |
23686246 | Zhang Y, et al. 2013. Ubiquitin-like domain of IKKβ regulates osteoclastogenesis and osteolysis. Calcified Tissue International, 78-85. |
Osteoporosis | ||
PMID | Publication | |
22333182 | Auld KL, et al. 2012. Estrogen-related receptor α regulates osteoblast differentiation via Wnt/β-catenin signaling. Journal of Molecular Biology, 177-191. |
Cancer
- Cancer
- Bladder Cancer
- Bone Cancer
- Breast Cancer
- Colorectal Cancer
- Cancer Drug Therapy
- Epithelial Cancer
- Glioma
- Cancer Immunotherapy Treatment
- Liver Cancer
- Lung Cancer
- Melanoma
- Neuroblastoma
- Opiod use for Cancer Pain
- Oral Cancer
- Pancreatic Cancer
- Prostate Cancer
- Cancer Radiation Therapy and Effects
- Cancer Resonance Imaging
- Super Oxide
- Thyroid Cancer
- Viruses related to Cancer
Cancer | ||
PMID | Publication | |
38626916 | Horvat, NK, et al. 2024. Superparamagnetic Iron Oxide Nanoparticles Reprogram the Tumor Microenvironment and Reduce Lung Cancer Regrowth after Crizotinib Treatment. ACS Nano, 11025-11041. | |
36192379 | AP Amini, et al. 2022. Multiscale profiling of protease activity in cancer. Nature Communications, 5745. | |
30405106 | Title, A.C., et al. 2018. Genetic dissection of the miR-200–Zeb1 axis reveals its importance in tumor differentiation and invasion. Nature Communications, 4671. | |
29848755 | J Alagu, et al. 2018. Tumor Suppressor p14ARF Enhances IFN-γ-Activated Immune Response by Inhibiting PIAS1 via SUMOylation. Journal of Immunology, 451-464. |
Bladder Cancer | ||
PMID | Publication | |
34938855 | JL Green, et al. 2021. Molecular characterization of type I IFN-induced cytotoxicity in bladder cancer cells reveals biomarkers of resistance. MolecularTherapy Oncolytics, 547-559. |
Bone Cancer | ||
PMID | Publication | |
30422869 | CK Appel, et al. 2019. Decitabine attenuates nociceptive behavior in a murine model of bone cancer pain. Pain, 619-631. |
Breast Cancer | ||
PMID | Publication | |
25965299 | Okoh VO, et al. 2015. Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells. British Journal of Cancer, 1687-1702. | |
23437041 | Okoh VO, et al. 2013. Reactive oxygen species via redox signaling to PI3K/AKT pathway contribute to the malignant growth of 4-hydroxy estradiol-transformed mammary epithelial cells. PLoS One, e54206. | |
15746050 | Dwyer RM, et al. 2005. In vivo radioiodide imaging and treatment of breast cancer xenografts after MUC1-driven expression of the sodium iodide symporter. Clinical Cancer Research, 1483-1489. |
Colorectal Cancer | ||
PMID | Publication | |
31239267 | C Tacconi, et al. 2019. Activation of the VEGFC/VEGFR3 Pathway Induces Tumor Immune Escape in Colorectal Cancer. Cancer Research, 4196-4210. | |
28886484 | Brandt, K.E., et al. 2018. Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells. Redox Biology, 82-87. | |
25754161 | Tacconi C, et al. 2015. Vascular endothelial growth factor C disrupts the endothelial lymphatic barrier to promote colorectal cancer invasion. Gastroenterology, 1438-1451. | |
15510175 | Scholz IV, et al. 2005. Radioiodine therapy of colon cancer following tissue-specific sodium iodide symporter gene transfer. Gene Therapy, 272-280. |
Cancer Drug Therapy | ||
PMID | Publication | |
35262628 | H Jiang, et al. 2022. Ferrous iron-activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors. Journal of Experimental Medicine, . | |
28389407 | Sciegienka, S.J., et al. 2017. D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via H2O2-mediated oxidative stress. Free Radical Biology and Medicine, 354-361. |
Epithelial Cancer | ||
PMID | Publication | |
27849011 | Wang Y, et al. 2016. Intrinsic cellular signaling mechanisms determine the sensitivity of cancer cells to virus-induced apoptosis. Scientific Reports, 37213. |
Glioma | ||
PMID | Publication | |
29755109 | Barrett, J.A., et al. 2018. Regulated intratumoral expression of IL-12 using a RheoSwitch Therapeutic System® (RTS®) gene switch as gene therapy for the treatment of glioma. Cancer Gene Therapy, 106-116. | |
28695888 | Cook PJ, et al. 2017. Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target. Nature Communications, 15987. |
Cancer Immunotherapy Treatment | ||
PMID | Publication | |
33335088 | AJ Wisdom, et al. 2020. Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy. Nature Communications, 6410. | |
26374823 | Gabitzsch ES, et al. 2015. The generation and analyses of a novel combination of recombinant adenovirus vaccines targeting three tumor antigens as an immunotherapeutic. Oncotarget, 31344-31359. | |
22737604 | Blalock LT, et al. 2012. Human dendritic cells adenovirally-engineered to express three defined tumor antigens promote broad adaptive and innate immunity. Oncoimmunology, 287-357. |
Liver Cancer | ||
PMID | Publication | |
26204498 | De la Rosa ÁJ, et al. 2016. Antitumoral gene-based strategy involving nitric oxide synthase type III overexpression in hepatocellular carcinoma. Gene Therapy, 67-77. |
Lung Cancer | ||
PMID | Publication | |
38626916 | Horvat, N.K., et al. 2024. Superparamagnetic Iron Oxide Nanoparticles Reprogram the Tumor Microenvironment and Reduce Lung Cancer Regrowth after Crizotinib Treatment. ACS Nano, . | |
37161053 | Berr AL, et al. 2023. Vimentin is required for tumor progression and metastasis in a mouse model of non–small cell lung cancer. Oncogene, 2074-2087. | |
36739466 | EK Kleczko, et al. 2023. Durable responses to alectinib in murine models of EML4-ALK lung cancer requires adaptive immunity. NPJ Precision Oncology, 15. | |
36538983 | Yang J, et al. 2023. Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10. Cancer Letters, 216025. | |
36192757 | N Merle, et al. 2022. Monitoring autochthonous lung tumors induced by somatic CRISPR gene editing in mice using a secreted luciferase. Molecular Cancer, 191. | |
36175034 | S Naranjo, et al. 2022. Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platform. Genes Development, 936-949. | |
36112789 | A Vaishnavi, et al. 2022. Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis. Cancer Research, 4261-4273. | |
32874131 | K Nolan, et al. 2020. Development of syngeneic murine cell lines for use in immunocompetent orthotopic lung cancer models. Cancer Cell International, 417. | |
29118090 | Kwak, J.W., et al. 2018. Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression. Cancer Research, 143-156. | |
26567140 | Green S, et al. 2015. PIK3CA(H1047R) Accelerates and Enhances KRAS(G12D)-Driven Lung Tumorigenesis. Cancer Research, 5378-5391. | |
26001956 | Shai A, et al. 2015. TP53 Silencing Bypasses Growth Arrest of BRAFV600E-Induced Lung Tumor Cells in a Two-Switch Model of Lung Tumorigenesis. Cancer Research, 3167-3180. | |
24589553 | Juan J, et al. 2014. Diminished WNT -> β-catenin -> c-MYC signaling is a barrier for malignant progression of BRAFV600E-induced lung tumors. Genes Development, 561-575. | |
24292713 | Glasauer A, et al. 2014. Targeting SOD1 reduces experimental non–small-cell lung cancer. Journal of Clinical Investigation, 117-128. | |
24019382 | Trejo CL, et al. 2013. Mutationally activated PIK3CA(H1047R) cooperates with BRAF(V600E) to promote lung cancer progression. Cancer Research, 6448-6461. | |
22511580 | Trejo CL, et al. 2012. MEK1/2 inhibition elicits regression of autochthonous lung tumors induced by KRASG12D or BRAFV600E. Cancer Research, 3048-3059. | |
22321727 | Rehman J, et al. 2012. Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer. FASEB Journal, 2175-2186. |
Melanoma | ||
PMID | Publication | |
33378390 | KC Kloepping, et al. 2020. Triphenylphosphonium derivatives disrupt metabolism and inhibit melanoma growth in vivo when delivered via a thermosensitive hydrogel. PLoS One, e0244540. |
Neuroblastoma | ||
PMID | Publication | |
23448979 | Carotenuto M, et al. 2013. Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction. Scientific Reports, 1351. |
Opioid Use for Cancer Pain | ||
PMID | Publication | |
28456745 | Viet CT, et al. 2017. OPRM1 Methylation Contributes to Opioid Tolerance in Cancer Patients. The Journal of Pain, 1046-1059. |
Oral Cancer | ||
PMID | Publication | |
33257729 | D Dang, et al. 2020. Targeting the endothelin axis as a therapeutic strategy for oral cancer metastasis and pain. Scientific Reports, 20832. | |
24963050 | Viet CT, et al. 2014. Demethylating drugs as novel analgesics for cancer pain. Clinical Cancer Research, 4882-4893. |
Pancreatic Cancer | ||
PMID | Publication | |
33404013 | JT Polaski, et al. 2021. The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma. Elife, e62209. | |
24509158 | Sibenaller ZA, et al. 2014. Extracellular superoxide dismutase suppresses hypoxia-inducible factor-1α in pancreatic cancer. Free Radical Biology and Medicine, 357-366. |
Prostate Cancer | ||
PMID | Publication | |
30009471 | Li, D., et al. 2018. Inhibition of androgen receptor transactivation function by adenovirus type 12 E1A undermines prostate cancer cell survival. Prostate, 140-1156. | |
29421238 | Zhong, W., et al. 2018. Extracellular redox state shift: A novel approach to target prostate cancer invasion. Free Radical Biology and Medicine, 99-109. | |
28108513 | Xiaowei Wei, et al. 2017. RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells. Cancer Research, 1345-1356. | |
27671770 | Tong Q, et al. 2016. MnTE-2-PyP modulates thiol oxidation in a hydrogen peroxide-mediated manner in a human prostate cancer cell. Free Radical Biology and Medicine, 32-43. | |
24369144 | Gao XF, et al. 2014. Radioiodine therapy for castration-resistant prostate cancer following prostate-specific membrane antigen promoter-mediated transfer of the human sodium iodide symporter. Asian Journal of Andrology, 120-123. |
Cancer Radiation Therapy and Effects | ||
PMID | Publication | |
39133651 | Su, C., et al. 2024. Enhancing radiotherapy response via intratumoral injection of a TLR9 agonist in autochthonous murine sarcomas. JCI Insight, . | |
36462795 | G Gonon, et al. 2022. Impact of the redox environment on propagation of radiation bystander effects: The modulating effect of oxidative metabolism and oxygen partial pressure. Mutation Research. Genetic Toxiocoly and Environmental Mutagenesis, . | |
36162051 | Patel R, et al. 2023. Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma. Molecular Cancer Therapies, 112-122. | |
35767986 | Nadkarni R, et al. 2022. Material decomposition from photon-counting CT using a convolutional neural network and energy-integrating CT training labels. Physics in Medicine and Biology, . | |
35314638 | AJ Allphin, et al. 2022. Photon Counting CT and Radiomic Analysis Enables Differentiation of Tumors Based on Lymphocyte Burden. Tomography, 740-753. | |
35100573 | Johnson TR, et al. 2022. An investigation of kV mini-GRID spatially fractionated radiation therapy: dosimetry and preclinical trial. Physics in Medicine and Biology, . | |
32718998 | RD Dodd, et al. 2020. Tumor Subtype Determines Therapeutic Response to Chimeric Polypeptide Nanoparticle-based Chemotherapy in Pten-deleted Mouse Models of Sarcoma. Clinical Cancer Research, 5036-5047. | |
32032663 | KC Falls-Hubert, et al. 2020. Disulfiram causes selective hypoxic cancer cell toxicity and radio-chemo-sensitization via redox cycling of copper. Free Radical Biology and Medicine, 45302. | |
31427882 | M Chen, et al. 2019. The Fusion Oncogene FUS-CHOP Drives Sarcomagenesis of High-Grade Spindle Cell Sarcomas in Mice. Sarcoma, 1340261. | |
24193032 | Grünwald GK, et al. 2013. EGFR-Targeted Adenovirus Dendrimer Coating for Improved Systemic Delivery of the Theranostic NIS Gene. Molecular Therapy. Nucleic Acids, e131. | |
23936314 | Stancevic B, et al. 2013. Adenoviral transduction of human acid sphingomyelinase into neo-angiogenic endothelium radiosensitizes tumor cure. PLoS One, e69025. | |
23843567 | Grünwald GK, et al. 2013. Systemic image-guided liver cancer radiovirotherapy using dendrimer-coated adenovirus encoding the sodium iodide symporter as theranostic gene. Journal of Nuclear Medicine, 1450-1457. | |
23038026 | Grünwald GK, et al. 2013. Sodium iodide symporter (NIS)-mediated radiovirotherapy of hepatocellular cancer using a conditionally replicating adenovirus. Gene Therapy, 625-633. |
Cancer Resonance Imaging | ||
PMID | Publication | |
37721686 | AG Rickard, et al. 2023. Evaluating Tumor Hypoxia Radiosensitization Via Electron Paramagnetic Resonance Oxygen Imaging (EPROI). Molecular Imaging and Biology, . |
Super Oxide | ||
PMID | Publication | |
36935009 | SS Sabharwal, et al. 2023. H2O2 transit through the mitochondrial intermembrane space promotes tumor cell growth in vitro and in vivo. Journal of Biological Chemistry, 104624. | |
36581766 | J Du, et al. 2022. The role of mitochondria in pharmacological ascorbate-induced toxicity. Scientific Reports, 22521. | |
33980575 | BJ Sishc, et al. 2021. Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide. Science Translational Medicine, eabb3768. | |
32512786 | Y Zhu, et al. 2020. MnTE-2-PyP Suppresses Prostate Cancer Cell Growth via H2O2 Production. Antioxidants, 490. | |
22392697 | Du J, et al. 2013. Regulation of pancreatic cancer growth by superoxide. Molecular Carcinogenesis, 555-567. |
Thyroid Cancer | ||
PMID | Publication | |
17931047 | Spitzweg C, et al. 2007. Image-guided radioiodide therapy of medullary thyroid cancer after carcinoembryonic antigen promoter-targeted sodium iodide symporter gene expression. Human Gene Therapy, 916-924. |
Viruses related to Cancer | ||
PMID | Publication | |
22241994 | Olmstead AD, et al. 2012. Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents. PLoS Pathology, e1002468. | |
26337747 | Rice AE, et al. 2015. An HPV-E6/E7 immunotherapy plus PD-1 checkpoint inhibition results in tumor regression and reduction in PD-L1 expression. Cancer Gene Therapy, 454-462. |
Cardiovascular
- Cardiovascular
- Arteriogenesis
- Angiogenesis
- Atherosclerosis
- Cardiac Hypertrophy
- Cardiotoxicity
- Cardiovascular Disease
- Glaucoma
- Heart Failure
- Hypertension
- Microvascular Lesions
- Noonan Syndrome
Cardiovascular | ||
PMID | Publication | |
38309417 | Wang Y, et al. 2024. Geranylgeranyl isoprenoids and hepatic Rap1a regulate basal and statin-induced expression of PCSK9. Journal of Lipid Research, 100515. | |
28882874 | Loregger A1, et al. 2017. Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis. Arteriosclerosis, Thrombosis, and Vascular Biology, 2064-2074. | |
28231341 | Cook EC, et al. 2017. Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene. PLoS One, e0172721. | |
27551042 | Caceres PS, et al. 2016. Vesicle-associated Membrane Protein 3 (VAMP3) Mediates Constitutive Trafficking of the Renal Co-transporter NKCC2 in Thick Ascending Limbs: ROLE IN RENAL FUNCTION AND BLOOD PRESSURE. Journal of Biological Chemistry, 22063-22073. | |
27528004 | Ang R, et al. 2015. The role of GαO-mediated signaling in the rostral ventrolateral medulla oblongata in cardiovascular reflexes and control of cardiac ventricular excitability. Physiological Reports, e12860. | |
27251289 | Tamer Sallam, et al. 2016. Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis. Nature, 124-128. | |
26098115 | Kelloniemi A, et al. 2015. The Early-Onset Myocardial Infarction Associated PHACTR1 Gene Regulates Skeletal and Cardiac Alpha-Actin Gene Expression. PLoS One, . | |
24363997 | Li S, et al. 2014. Over-expressed copper/zinc superoxide dismutase localizes to mitochondria in neurons inhibiting the angiotensin II-mediated increase in mitochondrial superoxide. Redox Biology, 8-14. | |
23269646 | Mendez M, et al. 2013. Role of the SNARE protein SNAP23 on cAMP-stimulated renin release in mouse juxtaglomerular cells. American Journal of Physiology. Renal Physiology, F498-504. | |
22437887 | Gebhard C, et al. 2012. Caffeine induces endothelial tissue factor expression via phosphatidylinositol 3-kinase inhibition. Thrombosis and Haemostasis, 884-894. |
Arteriogenesis | ||
PMID | Publication | |
28011587 | Joseph G, et al. 2017. Elevated 20-HETE impairs coronary collateral growth in metabolic syndrome via endothelial dysfunction. American Journal of Physiology. Heart and Circulatory Physiology, H528-H540. |
Angiogenesis | ||
PMID | Publication | |
31865373 | KB Collins, et al. 2019. Septin2 mediates podosome maturation and endothelial cell invasion associated with angiogenesis. Journal of Cellular Biology, . |
Atherosclerosis | ||
PMID | Publication | |
37491347 | L Yu, et al. 2023. Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice. Nature Communications, 4101. | |
34551209 | IF Hall, et al. 2021. rs41291957 controls miR-143 and miR-145 expression and impacts coronary artery disease risk. EMBO Molecular Medicine, e14060. | |
28972541 | Doran AC, et al. 2017. CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis. Journal of Clinical Investigation, 4075-4089. | |
24469459 | Blackstock CD, et al. 2014. Insulin-like growth factor-1 increases synthesis of collagen type I via induction of the mRNA-binding protein LARP6 expression and binding to the 5' stem-loop of COL1a1 and COL1a2 mRNA. Journal of Biological Chemistry, 7264-7274. | |
23912991 | Jiang XC, et al. 2013. Generation of general and tissue-specific gene knockout mouse models. Methods of Molecular Biology, 253-271. |
Cardiac Hypertrophy | ||
PMID | Publication | |
29128355 | Romano, N., et al. 2018. Upregulation of eIF6 inhibits cardiac hypertrophy induced by phenylephrine. Biochemical and Biophysical Research Communications, 601-606. |
Cardiotoxicity | ||
PMID | Publication | |
37499888 | Y Chen, et al. 2023. Ferroptosis contributes to catecholamine-induced cardiotoxicity and pathological remodeling. Free Radical Biology and Medicine, 227-238. |
Cardiovascular Disease | ||
PMID | Publication | |
29558369 | Elia, L., et al. 2018. UHRF1 epigenetically orchestrates smooth muscle cell plasticity in arterial disease. Journal of Clinical Investigation, 2473-2486. |
Glaucoma | ||
PMID | Publication | |
33539326 | RB Kasetti, et al. 2021. Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin. JCI Insight, e143359. |
Heart Failure | ||
PMID | Publication | |
27297082 | Collister JP, et al. 2016. Overexpression of copper/zinc superoxide dismutase in the median preoptic nucleus improves cardiac function after myocardial infarction in the rat. Clinical and Experimental Pharmacology and Physiology, 960-966. |
Hypertnesion | ||
PMID | Publication | |
28910144 | Budas GR, et al. 2017. ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine, 373-385. | |
26881025 | John P. Collister, et al. 2016. Angiotensin II-Induced Hypertension Is Attenuated by Overexpressing Copper/Zinc Superoxide Dismutase in the Brain Organum Vasculosum of the Lamina Terminalis. Oxidative Medicine and Cellular Longevity, 3959087. | |
25474089 | Collister JP, et al. 2014. Over-expression of copper/zinc superoxide dismutase in the median preoptic nucleus attenuates chronic angiotensin II-induced hypertension in the rat. Internation Journal of Molecular Science, 22203-22213. | |
25008321 | Caceres PS, et al. 2014. Vesicle-associated membrane protein 2 (VAMP2) but Not VAMP3 mediates cAMP-stimulated trafficking of the renal Na+-K+-2Cl- co-transporter NKCC2 in thick ascending limbs. Journal of Biological Chemistry, 23951-62. | |
24618552 | Tsang H, et al. 2013. Role of asymmetric methylarginine and connexin 43 in the regulation of pulmonary endothelial function. Pulmonary Circulation, 675-691. |
Microvascular Lesions | ||
PMID | Publication | |
27813591 | Dong W, et al. 2016. Preliminary in vitro analysis of mechanism of cardiac microvascular endothelial barrier function. Genetics and Molecular Research, . | |
25090023 | Das JK, et al. 2014. PCB153-induced overexpression of ID3 contributes to the development of microvascular lesions. PLoS One, e104159. |
Noonan Syndrome | ||
PMID | Publication | |
37450595 | Cuevas-Navarro A, et al. 2023. RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome–associated cardiac hypertrophy. Science Advances, eadf4766. |
Cell Biology
Cell Biology | ||
PMID | Publication | |
38805973 | Waldeck-Weiermair, M, et al. 2024. An essential role for EROS in redox-dependent endothelial signal transduction. Redox Biology, 103214. | |
37726294 | Y Chen, et al. 2023. Oxidative stress induces mitochondrial iron overload and ferroptotic cell death. Scientific Reports, 15515. | |
37590136 | A Kobiita, et al. 2023. FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress. Cell Reports, 112986. | |
36401888 | M Waldeck-Weiermair, et al. 2022. Differential endothelial hydrogen peroxide signaling via Nox isoforms: Critical roles for Rac1 and modulation by statins. Redox Biology, 102539. | |
35262628 | H Jiang, et al. 2022. Ferrous iron-activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors. Journal of Experimental Medicine, . | |
35002214 | S Gindina, et al. 2021. Tissue plasminogen activator rescues steroid-induced outflow facility reduction via non-enzymatic action. Molecular Vision, 691-705. | |
34774525 | Y Chiang, et al. 2021. Sphingomyelin synthases 1 and 2 exhibit phosphatidylcholine phospholipase C activity. Journal of Biological Chemistry, 101398. | |
34332077 | Y Chiang, et al. 2021. Sphingomyelin synthase related protein is a mammalian phosphatidylethanolamine phospholipase C. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 159017. | |
34230483 | H Torres-Torrelo, et al. 2021. Lactate sensing mechanisms in arterial chemoreceptor cells. Nature Communications, 4166. | |
34027492 | L Gao, et al. 2021. Using redox-sensitive fluorescent probes to record real-time reactive oxygen species production in cells from mouse carotid body slices. STAR Protocols, 100535. | |
33154371 | RB Kasetti, et al. 2020. ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load. Nature Communications, 5594. | |
32438526 | J Kersigo, et al. 2021. Effects of Neurod1 Expression on Mouse and Human Schwannoma Cells. Laryngoscope, E259-E270. | |
31537645 | MC de Miranda, et al. 2019. Epidermal growth factor (EGF) triggers nuclear calcium signaling through the intranuclear phospholipase Cδ-4 (PLCδ4). Journal of Biological Chemistry, 16650-16662. | |
30415700 | Rodriguez-Rodriguez, J.A., et al. 2018. Distinct roles of RZZ and Bub1-KNL1 in mitotic checkpoint signaling and kinetochore expansion. Current Biology, 3422-3429. | |
30087458 | Jung, M., et al. 2018. Lipocalin-2 abrogates epithelial cell cycle arrest by PPARγ inhibition. Lab Investigation, 1408-1422. | |
30003094 | Freundt, J.K., et al. 2018. The Transcription Factor ATF4 Promotes Expression of Cell Stress Genes and Cardiomyocyte Death in a Cellular Model of Atrial Fibrillation. BioMed Research Institute, 3694362. | |
28003364 | Leech CA, et al. 2017. Stromal Interaction Molecule 1 (STIM1) Regulates ATP-sensitive Potassium (KATP) and Store-operated Ca2+ Channels in MIN6 β-Cells. Journal of Biological Chemistry, 2266-2277. | |
27753532 | Paul PK, et al. 2016. Histone chaperone ASF1B promotes human β-cell proliferation via recruitment of histone H3.3. Cell Cycle, 3191-3202. | |
27744291 | Gay O, et al. 2016. Refilins are short-lived Actin-bundling proteins that regulate lamellipodium protrusion dynamics. Biology Open, 1351-1361. | |
27620490 | Yun B, et al. 2016. Off-target effect of the cPLA2α inhibitor pyrrophenone: Inhibition of calcium release from the endoplasmic reticulum. Biochemical and Biophysical Research Communications, 61-66. | |
27470512 | Song SH, et al. 2016. Fibroblast Growth Factor 12 Is a Novel Regulator of Vascular Smooth Muscle Cell Plasticity and Fate. Arteriosclerosis, Thrombosis, and Vascular Biology, 1928-1936. | |
27142834 | Tokhtaeva E, et al. 2016. The O-glycosylated ectodomain of FXYD5 impairs adhesion by disrupting cell-cell trans-dimerization of Na,K-ATPase β1 subunits. Journal of Cell Science, 2394-2406. | |
26538436 | AB Jaykumar, et al. 2016. Real-time monitoring of NKCC2 endocytosis by total internal reflection fluorescence (TIRF) microscopy. American Journal of Physiology. Renal Physiology, F183-F191. | |
26429917 | Krisenko MO, et al. 2015. Syk Is Recruited to Stress Granules and Promotes Their Clearance through Autophagy. Journal of Biological Chemistry, 27803-27815. | |
25806685 | Rong X, et al. 2015. Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion. Elife, e06557. | |
24506535 | Wang Y, et al. 2014. Uncoupling of Cav1.2 from Ca(2+)-induced Ca(2+) release and SK channel regulation in pancreatic β-cells. Molecular Endocrinology, 458-476. | |
24109596 | Neto H, et al. 2013. Syntaxin 16 is a master recruitment factor for cytokinesis. Molecular Biology of the Cell, 3663-3674. | |
23419260 | Zhang L, et al. 2013. Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor. Journal of Lipid Research, 1410-1420. | |
22422475 | In JG, et al. 2012. Analysis of polarized membrane traffic in hepatocytes and hepatic cell lines. Current Protocols in Cell Biology, . | |
22262167 | Yang H, et al. 2012. Downregulation of Mdm2 and Mdm4 enhances viral gene expression during adenovirus infection. Cell Cycle, 582-593. | |
22041456 | Owens, K.M., et al. 2012. Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-•) and H2O2. Free Radical Biology and Medicine, 160-166. | |
36012732 | J Woo, et al. 2022. Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12). International Journal of Molecular Science, 9467. | |
32278283 | JM Stolwijk, et al. 2020. Simultaneous detection of the enzyme activities of GPx1 and GPx4 guide optimization of selenium in cell biological experiments. Redox Biology, 101518. | |
32396862 | D Guallar, et al. 2020. ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress. Cell Stem Cell, 300-314. | |
24598361 | Koppel AC, et al. 2014. Delayed skin wound repair in proline-rich protein tyrosine kinase 2 knockout mice. American Journal of Physiology. Cell Physiology, C899-C909. | |
32628158 | AT Aliyev, et al. 2020. Assessment of Cellular Oxidation using a Subcellular Compartment-Specific Redox-Sensitive Green Fluorescent Protein. Journal of Visualized Experiments, . |
Diabetes
- Diabetes
- Glucagon
- Gluconeogenesis
- Insulin Resistance
- Kidney Disease
- Trim-Away
- Non-Alchoholic Fatty Liver Disease
- Obesity
Diabetes | ||
PMID | Publication | |
38203312 | J Hwang, et al. 2023. A Novel Role for DOC2B in Ameliorating Palmitate-Induced Glucose Uptake Dysfunction in Skeletal Muscle Cells via a Mechanism Involving β-AR Agonism and Cofilin. International Journal of Molecular Medicine, 137. | |
37759961 | R Balakrishnan, et al. 2023. Toward Ameliorating Insulin Resistance: Targeting a Novel PAK1 Signaling Pathway Required for Skeletal Muscle Mitochondrial Function. Antioxidants, 1658. | |
37294632 | A Pelligra, et al. 2023. Pancreatic islet protection at the expense of secretory function involves serine-linked mitochondrial one-carbon metabolism. Cell Reports, 112615. | |
36543979 | K Griess, et al. 2023. Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis. Nature Cell Biology, 20-29. | |
36446811 | AM Koester, et al. 2022. GLUT4 translocation and dispersal operate in multiple cell types and are negatively correlated with cell size in adipocytes. Scientific Reports, 20535. | |
36001955 | Y Wang, et al. 2022. Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia. Cell Reports, 111259. | |
35377441 | Chatterjee Bhowmick D, et al. 2022. DOC2b enhances β-cell function via a novel tyrosine phosphorylation-dependent mechanism. Diabetes, 1246-1260. | |
35222279 | KE Merz, et al. 2022. Changes in Skeletal Muscle PAK1 Levels Regulate Tissue Crosstalk to Impact Whole Body Glucose Homeostasis. Frontiers in Endocrinology, 821849. | |
34371064 | K Meneyrol, et al. 2021. Ovarian insufficiency impairs glucose-stimulated insulin secretion through activation of hypothalamic de novo ceramide synthesis. Metabolism, 154846. | |
34303021 | W Dai, et al. 2021. Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance. Molecular Metabolism, 101300. | |
34116231 | AC Title, et al. 2021. The miR-200-Zeb1 axis regulates key aspects of β-cell function and survival in vivo. Molecular Metabolism, 101267. | |
33172888 | MD Schaid, et al. 2021. Agonist-independent Gαz activity negatively regulates beta-cell compensation in a diet-induced obesity model of type 2 diabetes. Journal of Biological Chemistry, 100056. | |
32640216 | A Kobiita, et al. 2020. The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress. Cell Reports, 107846. | |
32341128 | B Yau, et al. 2020. A fluorescent timer reporter enables sorting of insulin secretory granules by age. Journal of Biological Chemistry, 8901-8911. | |
30707251 | J Zhang, et al. 2019. DOC2B promotes insulin sensitivity in mice via a novel KLC1-dependent mechanism in skeletal muscle. Diabetologia, 845-859. | |
30305365 | Oh, E., et al. 2018. Syntaxin 4 expression in pancreatic β-cells promotes islet function and protects functional β-cell mass. Diabetes, 2626-2639. | |
30131394 | Kono, T., et al. 2018. Impaired store-operated calcium entry and STIM1 loss lead to reduced insulin secretion and increased endoplasmic reticulum stress in the diabetic β-cell. Diabetes, 2293-2304. | |
29661782 | Arianne Aslamy, et al. 2018. Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function. Diabetes, 1332-1344. | |
29491394 | Chepurny, O.G., et al. 2018. Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors. Scientific Reports, 3749. | |
27394663 | Ahn M, et al. 2016. The p21-activated kinase (PAK1) is involved in diet-induced beta cell mass expansion and survival in mice and human islets. Diabetologia, 2145-2155. | |
27007848 | Stanley, S.A., et al. 2016. Bidirectional electromagnetic control of the hypothalamus regulates feeding and metabolism. Nature, 647-650. | |
26394663 | Lavine JA, et al. 2015. Cholecystokinin expression in the β-cell leads to increased β-cell area in aged mice and protects from streptozotocin-induced diabetes and apoptosis. American Journal of Physiology. Endrocrinology and Metabolism, E819-E828. | |
26348837 | Kluth O, et al. 2015. Identification of Four Mouse Diabetes Candidate Genes Altering β-Cell Proliferation. PLoS Genetics, e1005506. | |
25985365 | Belgardt BF, et al. 2015. The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes. Nature Medicine, 619-627. | |
25295789 | Raichur S, et al. 2014. CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance. Cell Metabolism, 687-695. | |
24732803 | Kawano Y, et al. 2014. Thioesterase superfamily member 2 (Them2) and phosphatidylcholine transfer protein (PC-TP) interact to promote fatty acid oxidation and control glucose utilization. Molecular and Cellular Biology, 2396-2408. | |
24610809 | Yoder SM, et al. 2014. YES, a Src family kinase, is a proximal glucose-specific activator of cell division cycle control protein 42 (Cdc42) in pancreatic islet β cells. Journal of Biological Chemistry, 11476-11487. | |
24466075 | van Stijn CM, et al. 2014. Adiponectin expression protects against angiotensin II-mediated inflammation and accelerated atherosclerosis. PLoS One, e86404. | |
24424049 | Neumann UH, et al. 2014. IGFBP2 is neither sufficient nor necessary for the physiological actions of leptin on glucose homeostasis in male ob/ob mice. Endocrinology, 716-725. | |
22888137 | Huber AK, et al. 2012. Genetically driven target tissue overexpression of CD40: a novel mechanism in autoimmune disease. Journal of Immunology, 3043-3053. | |
22394502 | Hall AM, et al. 2012. Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver. Journal of Lipid Research, 990-999. | |
22108804 | Kalwat MA, et al. 2012. Gelsolin associates with the N terminus of syntaxin 4 to regulate insulin granule exocytosis. Molecular Endocrinology, 128-141. | |
15538371 | Poy MN, et al. 2004. A pancreatic islet-specific microRNA regulates insulin secretion. Nature, 226-230. |
Glucagon | ||
PMID | Publication | |
30582457 | S Spolitu, et al. 2019. Hepatic Glucagon Signaling Regulates PCSK9 and Low-Density Lipoprotein Cholesterol. Circulation, 38-51. |
Gluconeogenesis | ||
PMID | Publication | |
31597092 | KC Nikolaou, et al. 2019. The RNA-Binding Protein A1CF Regulates Hepatic Fructose and Glycerol Metabolism via Alternative RNA Splicing. Cell Reports, 283-300. | |
28714135 | Hu Y, et al. 2017. YAP suppresses gluconeogenic gene expression through PGC1α. Hepatology, 2029-2041. |
Insulin Resistance | ||
PMID | Publication | |
30523156 | V Tillander, et al. 2019. Thioesterase superfamily member 2 promotes hepatic insulin resistance in the setting of glycerol-3-phosphate acyltransferase 1-induced steatosis. Journal of Biological Chemistry, 2009-2020. | |
23832089 | Pajvani UB, et al. 2013. Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability. Nature Medicine, 1054-1060. | |
22474127 | Hu S, et al. 2012. Peroxisome proliferator-activated receptor γ decouples fatty acid uptake from lipid inhibition of insulin signaling in skeletal muscle. Molecular Endocrinology, 977-988. |
Kidney Disease | ||
PMID | Publication | |
30407737 | R Guiteras, et al. 2019. Exploring macrophage cell therapy on Diabetic Kidney Disease. Journal Cellular and Molecular Medicine, 841-851. |
Trim-Away/ Liver Disease | ||
PMID | Publication | |
37937648 | KC Nikolaou, et al. 2023. Inflammation-induced TRIM21 represses hepatic steatosis by promoting the ubiquitination of lipogenic regulators. JCI Insight, e164694. |
Non-Alcoholic Fatty Liver Disease | ||
PMID | Publication | |
24362075 | Castaño D, et al. 2014. Cardiotrophin-1 eliminates hepatic steatosis in obese mice by mechanisms involving AMPK activation. Journal of Hepatology, 1017-1025. |
Obesity | ||
PMID | Publication | |
33449689 | BT Milliken, et al. 2021. Design and Evaluation of Peptide Dual-Agonists of GLP-1 and NPY2 Receptors for Glucoregulation and Weight Loss with Mitigated Nausea and Emesis. Journal of Medicinal Chemistry, 1127-1138. | |
33352310 | B Chaurasia, et al. 2021. Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes. Molecular Metabolism, 101145. | |
27110486 | Okada, K., et al. 2016. Thioesterase superfamily member 1 suppresses cold thermogenesis by limiting the oxidation of lipid droplet-derived fatty acids in brown adipose tissue. Molecular Metabolism, 340-351. | |
26909312 | Quiñones M, et al. 2015. Hypothalamic CaMKKβ mediates glucagon anorectic effect and its diet-induced resistance. Molecular Metabolism, 961-970. |
Fatty Acids
Fatty Acids | ||
PMID | Publication | |
30223548 | Alam, S., et al. 2018. PCB11 Metabolite, 3, 3'-Dichlorobiphenyl-4-ol, Exposure Alters the Expression of Genes Governing Fatty Acid Metabolism in the Absence of Functional Sirtuin 3 …. Antioxidants, 121. | |
29317465 | Lin, J., et al. 2018. Perilipin 5 and liver fatty acid binding protein function to restore quiescence in mouse hepatic stellate cells [S]. Journal of Lipid Research, 46-428. |
Bioenergetics | ||
PMID | Publication | |
34108467 | Y Li, et al. 2021. Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice. Nature Communications, 3493. |
Lipogenesis | ||
PMID | Publication | |
31227231 | EA Lane, et al. 2019. HCF-1 Regulates De Novo Lipogenesis through a Nutrient-Sensitive Complex with ChREBP. Molecular Cell, 357-371. |
Fibrosis
Fibrosis | ||
PMID | Publication | |
32977155 | IG Luzina, et al. 2020. Full-length IL-33 regulates Smad3 phosphorylation and gene transcription in a distinctive AP2-dependent manner. Cell Immunology, 104203. | |
28793288 | Guiteras R, et al. 2017. Macrophage Overexpressing NGAL Ameliorated Kidney Fibrosis in the UUO Mice Model. Cellular Physiology and Biochemistry, 1945-1960. | |
26993524 | Luzina IG, et al. 2016. Elevated expression of NEU1 sialidase in idiopathic pulmonary fibrosis provokes pulmonary collagen deposition, lymphocytosis, and fibrosis. American Journal of Physiology. Lung Cellular and Molecular Physiology, L940-L954. | |
25786688 | Hashimoto M1, et al. 2015. A critical role for dendritic cells in the evolution of IL-1β-mediated murine airway disease. Journal of Immunology, 3962-3969. | |
25188360 | Morales-Nebreda LI, et al. 2015. Lung-specific loss of α3 laminin worsens bleomycin-induced pulmonary fibrosis. American Journal of Respiratory Cell and Molecular Biology, 503-512. |
Fibronolysis | ||
PMID | Publication | |
30504459 | Z Zheng, et al. 2019. An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1. Blood, 743-753. |
Gene Editing / Expression, CRISPR/Cas9
CRISPR/ Cas 9 | ||
PMID | Publication | |
37684258 | QR Brockman, et al. 2023. Discrepancies in indel software resolution with somatic CRISPR/Cas9 tumorigenesis models. Scientific Reports, 14798. | |
37470475 | L Schubert, et al. 2023. A functional sgRNA-CRISPR screening method for generating murine RET and NTRK1 rearranged oncogenes. Biology Open, bio059994. | |
34099655 | A Goga, et al. 2021. miR-802 regulates Paneth cell function and enterocyte differentiation in the mouse small intestine. Nature Communications, 3339. | |
32456131 | A Scherer, et al. 2020. Distinct Tumor Microenvironments Are a Defining Feature of Strain-Specific CRISPR/Cas9-Induced MPNSTs. Genes, 583. | |
31209054 | J Lee, et al. 2019. Direct delivery of adenoviral CRISPR/Cas9 vector into the blastoderm for generation of targeted gene knockout in quail. PNAS: USA, 13288-13292. | |
28691711 | Huang J, et al. 2017. Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma. Nature Communications, 15999. | |
26086867 | Wang D, et al. 2015. Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses. Human Gene Therapy, 432-42. | |
25337876 | Maddalo D, et al. 2014. In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system. Nature, 423-427. |
Hyperoxia / Hypoxia
Hyperoxia/Hypoxia | ||
PMID | Publication | |
34596045 | A Kumar, et al. 2021. HIF1α stabilization in hypoxia is not oxidant-initiated. Elife, e72873. | |
31848220 | A Moreno-Domínguez, et al. 2020. Acute O2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors. Sicence Signaling , 615. | |
29887397 | Arias-Mayenco, I., et al. 2018. Acute O2 Sensing: Role of Coenzyme QH2/Q Ratio and Mitochondrial ROS Compartmentalization. Cell Metabolism, 145-158. | |
22229392 | Farrow KN, et al. 2012. Brief hyperoxia increases mitochondrial oxidation and increases phosphodiesterase 5 activity in fetal pulmonary artery smooth muscle cells. Antioxidants and Redox Signaling, 460-470. |
Oxidative Stress | ||
PMID | Publication | |
25416362 | Alim I, et al. 2014. Spatial, temporal, and quantitative manipulation of intracellular hydrogen peroxide in cultured cells. Methods of Enzymology, 251-273. |
Phosphorylation | ||
PMID | Publication | |
32590330 | SSS Saravi, et al. 2020. Differential endothelial signaling responses elicited by chemogenetic H2O2 synthesis. Redox Biology, 101605. |
Metabolic Side-Effects | ||
PMID | Publication | |
32733884 | T Eberhart, et al. 2020. Peroxisome-Deficiency and HIF-2α Signaling Are Negative Regulators of Ketohexokinase Expression. Frontiers in Cell and Developmental Biology, 566. |
Hyperthyroidism
PMID | Publication |
22294347 | Varela L, et al. 2012. Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism. Journal of Pathology, 209-222. |
Graves Disease | ||
PMID | Publication | |
35881515 | K Merakchi, et al. 2022. Murine Thyroid IL-4 Expression Worsens Hypothyroidism on Iodine Restriction and Mitigates Graves Disease Development. Endocrinology, . | |
32228171 | LC Faustino, et al. 2020. A Novel Mouse Model of Autoimmune Thyroiditis Induced by Immunization with Adenovirus Containing Full-Length Thyroglobulin cDNA: Implications to Genetic Studies of Thyroid Autoimmunity. Thyroid, 1338-1345. | |
31980336 | CW Li, et al. 2020. Cepharanthine blocks TSH receptor peptide presentation by HLA-DR3: Therapeutic implications to Graves' disease. Journal of Autoimmunity, 102402. | |
25051451 | McLachlan SM, et al. 2014. Immunoglobulin heavy chain variable region and major histocompatibility region genes are linked to induced graves' disease in females from two very large families of recombinant inbred mice. Endocrinology, 4094-4103. |
Immunology
PMID | Publication |
31468569 | LI Labzin, et al. 2019. Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection. EMBO Journal, e101365. |
30856600 | IG Luzina, et al. 2019. Identification of the IL-33 protein segment that controls subcellular localization, extracellular secretion, and functional maturation. Cytokine, 1-6. |
30115681 | De, S., et al. 2018. Mechanism of dysfunction of human variants of the IRAK4 kinase and a role for its kinase activity in interleukin-1 receptor signaling. Journal of Biological Chemistry, 15208-15220. |
29249357 | Rajbhandari, P., et al. 2018. IL-10 signaling remodels adipose chromatin architecture to limit thermogenesis and energy expenditure. Cell, 218-233. |
28732035 | Martins MA, et al. 2017. Vaccine-induced immune responses against both Gag and Env improve control of simian immunodeficiency virus replication in rectally challenged rhesus macaques. PLoS Pathology, e1006529. |
27881870 | Bottermann, M., et al. 2016. Antibody-antigen kinetics constrain intracellular humoral immunity. Scientific Reports, 37457. |
Arthritis | ||
PMID | Publication | |
34398520 | P Seoane‐Collazo, et al. 2022. Activation of Hypothalamic AMP-Activated Protein Kinase Ameliorates Metabolic Complications of Experimental Arthritis. Arthritis and Rheumatology, 212-222. |
Inflammation | ||
PMID | Publication | |
25686493 | Boaru SG, et al. 2015. NLRP3 inflammasome expression is driven by NF-κB in cultured hepatocytes. Biochemical and Biophysical Research Communications, 700-706. | |
25349202 | Jung YJ, et al. 2014. SIRT2 Regulates LPS-Induced Renal Tubular CXCL2 and CCL2 Expression. Journal of American Society of Nephrology, 1549-1560. | |
24619410 | Kopach P, et al. 2014. IFN-γ directly controls IL-33 protein level through a STAT1- and LMP2-dependent mechanism. Journal of Biological Chemistry, 11829-11843. | |
24485460 | Goddard LM, et al. 2014. Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation. Cell, 549-562. | |
24206663 | Rong X, et al. 2013. LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell Metabolism, 685-697. | |
23525087 | Do-Umehara HC, et al. 2013. Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ. Nature Immunology, 461-469. |
Inflammatory Bowel Disease | ||
PMID | Publication | |
25105363 | D'Alessio S, et al. 2014. VEGF-C-dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease. Journal of Clinical Investigation, 3863-3878. |
Psoriasis | ||
PMID | Publication | |
24574341 | Guinea-Viniegra J, et al. 2014. Targeting miR-21 to treat psoriasis. Science Translational Medicine, 225re1. |
TRIM21/Trim-Away | ||
PMID | Publication | |
37061529 | L Kiss, et al. 2023. Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates. Nature Communications, 2160. | |
35486676 | S Foss, et al. 2022. Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge. Science Immunology, eabj1640. | |
33633400 | J Zeng, et al. 2021. Target-induced clustering activates Trim-Away of pathogens and proteins. Nature Structure and Molecular Biology, 278-289. | |
31613747 | J Zeng, et al. 2019. Rare missense variants in the human cytosolic antibody receptor preserve antiviral function. Elife, e48339. | |
31582740 | L Kiss, et al. 2019. A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases. Nature Communications, 4502. | |
30926239 | M Bottermann, et al. 2019. Complement C4 Prevents Viral Infection through Capsid Inactivation. Cell Host Microbe, 617-629. | |
30796180 | PML Ng, et al. 2019. Enhancing Antigen Cross-Presentation in Human Monocyte-Derived Dendritic Cells by Recruiting the Intracellular Fc Receptor TRIM21. Journal of Immunology, 2307-2319. | |
29667579 | Claire Dickson† , et al. 2018. Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21. Elife, e32660. | |
26506431 | Watkinson RE, et al. 2015. TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus. PLoS Pathology, e1005253. | |
26150489 | Fletcher AJ, et al. 2015. Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21. PNAS: USA, 10014-10019. | |
25169018 | Bidgood SR, et al. 2014. Translocalized IgA mediates neutralization and stimulates innate immunity inside infected cells. PNAS: USA, 13463-8. |
Lipid Metabolism
PMID | Publication |
36522129 | L Bideyan, et al. 2022. Hepatic GATA4 regulates cholesterol and triglyceride homeostasis in collaboration with LXRs. Genes Development, 1129-1144. |
32111832 | A Loregger, et al. 2020. Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism. Nature Communications, 1128. |
29068315 | Zhang L, et al. 2017. Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP. Elife, e28766. |
28063500 | Yun B, et al. 2017. Cellular Assays for Evaluating Calcium-Dependent Translocation of cPLA2α to Membrane. Methods in Enzymology, 71-99. |
27665711 | Mobin MB, et al. 2016. The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation. Nature Communications, 12848. |
25440060 | Walter KM, et al. 2014. Hif-2α promotes degradation of mammalian peroxisomes by selective autophagy. Cell Metabolism, 882-897. |
23416070 | von Meyenn F, et al. 2013. Glucagon-induced acetylation of Foxa2 regulates hepatic lipid metabolism. Cell Metabolism, 436-447. |
16459311 | Wolfrum C, et al. 2006. Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion. Cell Metabolism, 99-110. |
15793583 | Wolfrum C, et al. 2005. Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis. Nature Medicine, 418-422. |
15616563 | Wolfrum C, et al. 2004. Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes. Nature, 1027-1032. |
12865419 | C Wolfrum, et al. 2003. Role of Foxa-2 in adipocyte metabolism and differentiation. Journal of Clinical Investigation, 345-356. |
Adipogenesis | ||
PMID | Publication | |
30355480 | Gulyaeva, O., et al. 2018. Sox9-Meis1 inactivation is required for adipogenesis, advancing Pref-1+ to PDGFRα+ cells. Cell Reports, 1002-1017. | |
28192372 | Wang J, et al. 2017. RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs. Journal of Clinical Investigation, 987-1004. | |
23152581 | Halperin DS, et al. 2013. Vestigial-like 3 is an inhibitor of adipocyte differentiation. Journal of Lipid Research, 473-481. | |
22579288 | Whittle AJ, et al. 2012. BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell, 871-885. |
Thermogenesis | ||
PMID | Publication | |
23473036 | Villanueva CJ, et al. 2013. Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. Cell Metabolism, 423-435. |
Liver
Hepatic Metabolism | ||
PMID | Publication | |
31692367 | M Conde-Sieira, et al. 2020. Hypothalamic AMPKα2 regulates liver energy metabolism in rainbow trout through vagal innervation. American Journal of Physiology. Regulatory, integrative, and comparative physiology, R122-R134. | |
30460617 | M Conde-Sieira, et al. 2019. Differential Role of Hypothalamic AMPKα Isoforms in Fish: an Evolutive Perspective. Molecular Neurobiology, 5051-5066. | |
28877455 | Simcox J, et al. 2017. Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis. Cell Metabolism, 509-522. |
Liver Disease | ||
PMID | Publication | |
39153480 | LaMoia, T.E., et al. 2024. Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipolysis, and gluconeogenesis via CAMKII activation. Cell Metabolism, . | |
37586586 | Chiang, YP, et al. 2023. Sphingomyelin synthase-related protein SMSr is a phosphatidylethanolamine phospholipase C that promotes nonalcoholic fatty liver disease. The Journal of Biological Chemistry, 105162. | |
37230004 | V Ferreira, et al. 2023. Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via intraperitoneal: Additional effects of PTP1B inhibition. Redox Biology, 102741. | |
35476518 | C Priest, et al. 2022. Brap regulates liver morphology and hepatocyte turnover via modulation of the Hippo pathway. PNAS: USA, . | |
28480888 | Porteiro B, et al. 2017. Hepatic p63 regulates steatosis via IKKβ/ER stress. Nature Communications, 15111. | |
21887698 | Krützfeldt J, et al. 2012. MicroRNA-194 is a target of transcription factor 1 (Tcf1, HNF1α) in adult liver and controls expression of frizzled-6. Hepatology, 98-107. | |
35294257 | D Böck, et al. 2022. In vivo prime editing of a metabolic liver disease in mice. Science Translational Medicine, eabl9238. |
Microbiology
Helicobacter Pylori | ||
PMID | Publication | |
32174134 | EA Marcus, et al. 2020. Helicobacter pylori infection impairs chaperone-assisted maturation of Na-K-ATPase in gastric epithelium. American Journal of Physiology. Gastrointestinal and Liver Physiology, G931-G945. |
Lymes Disease | ||
PMID | Publication | |
23141105 | Ullmann AJ, et al. 2012. Immunization with adenoviral-vectored tick salivary gland proteins (SALPs) in a murine model of Lyme borreliosis. Ticks and Tick Borne Diseases, 160-163. |
Tuberculosis | ||
PMID | Publication | |
23904160 | Bladwin, SL, et al. 2013. Protection against tuberculosis with homologous or heterologous protein/vector vaccine approaches is not dependent on CD8+ T cells. Journal of Immunology, 2514-2525. |
Muscle
Muscle Disease | ||
PMID | Publication | |
31948476 | C Whitmore, et al. 2020. The ERG1a potassium channel increases basal intracellular calcium concentration and calpain activity in skeletal muscle cells. Skeletal Muscle, 1. | |
23860742 | Owens J, et al. 2013. Characterization of primary human skeletal muscle cells from multiple commercial sources. In Vitro Cellualer and Developmental Biology. Animal, 695-705. |
Muscular Dystrophy | ||
PMID | Publication | |
32975514 | AS Walimbe, et al. 2020. POMK regulates dystroglycan function via LARGE1-mediated elongation of matriglycan. Elife, e61388. | |
27879205 | Zhu Q, et al. 2016. Structure of protein O-mannose kinase reveals a unique active site architecture. Elife, e22238. | |
24682306 | Saccone V, et al. 2014. HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles. Genes Development, 841-857. |
Neuroscience
- Alzheimer’s Disease
- Neurodegenerative Disease
- Battens Disease
- Parkinsons Disease
- Selenium
- Spinal Cord Injury
PMID | Publication |
38569938 | Deep, S.N., et al. 2024. Homocysteine-induced sustained GluN2A NMDA receptor stimulation leads to mitochondrial ROS generation and neurotoxicity. Journal of Biological Chemistry, 107253. |
36823656 | D Song, et al. 2023. Low-intensity pulsed ultrasound triggers a beneficial neuromodulation in dementia mice with chronic cerebral hypoperfusion via activation of hippocampal Fndc5/irisin signaling. Journal of Translational Medicine, 139. |
33154371 | RB Kasetti, et al. 2020. ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load. Nature Communications, 5594. |
30294906 | Karuppagounder, S.S., et al. 2018. N‐acetylcysteine targets 5 lipoxygenase‐derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following …. Annals of Neurology, 854-872. |
30074985 | Chan, J.P., et al. 2018. The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain. PLoS Biology, e2006443. |
28402971 | Kichev A, et al. 2017. Implicating Receptor Activator of NF-κB (RANK)/RANK Ligand Signalling in Microglial Responses to Toll-Like Receptor Stimuli. Developmental Neuroscience, 192-206. |
26936506 | Karuppagounder SS, et al. 2016. Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Science Translational Medicine, 328ra29. |
23103326 | Brim BL, et al. 2013. Memory in aged mice is rescued by enhanced expression of the GluN2B subunit of the NMDA receptor. Behavior Brain Research, 211-226. |
Alzheimer’s Disease | ||
PMID | Publication | |
37453419 | A Kumar, et al. 2023. 2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer's resilience. Neuron, 2831-2846. | |
30617325 | MV Lourenco, et al. 2019. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models. Nature Medicine, 165-175. | |
28049840 | McEwan WA, et al. 2017. Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation. PNAS: USA, 574-579. |
Neurodegenerative Disease | ||
PMID | Publication | |
37942487 | Murray SJ, et al. 2023. Efficacy of dual intracerebroventricular and intravitreal CLN5 gene therapy in sheep prompts the first clinical trial to treat CLN5 Batten disease. Frontiers in Pharmacology, 1212235. | |
37614821 | NL Mitchell, et al. 2023. Long-term safety and dose escalation of intracerebroventricular CLN5 gene therapy in sheep supports clinical translation for CLN5 Batten disease. Frontiers in Genetics, 1212228. | |
36272468 | V Ferreira, et al. 2022. Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight. Metabolism, 155335. | |
35508140 | Tuck BJ, et al. 2022. Cholesterol determines the cytosolic entry and seeded aggregation of tau. Cell Reports, 110776. |
Batten’s Disease | ||
PMID | Publication | |
37246363 | NL Mitchell, et al. 2023. Characterization of neuropathology in ovine CLN5 and CLN6 neuronal ceroid lipofuscinoses (Batten disease). Developmental Neurobiology, 127-142. |
Parkinsons Disease | ||
PMID | Publication | |
24117733 | Luerman GC, et al. 2014. Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1. Journal of Neurochemistry, 561-576. |
Selenium | ||
PMID | Publication | |
31056284 | I Alim, et al. 2019. Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke. Cell, 1262-1279. |
Spinal Cord Injury | ||
PMID | Publication | |
25740503 | North HA, et al. 2015. β1-Integrin alters ependymal stem cell BMP receptor localization and attenuates astrogliosis after spinal cord injury. Journal of Neuroscience, 3725-3733. |
Obesity
PMID | Publication |
34675439 | E Milbank, et al. 2021. Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation. Nature Metabolism, 1415-1431. |
33080217 | V Heras, et al. 2020. Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty. Cell Metabolism, 951-966. |
31775033 | D Yi, et al. 2019. Zc3h10 Acts as a Transcription Factor and Is Phosphorylated to Activate the Thermogenic Program. Cell Reports, 2621-2633. |
30448371 | R Rodríguez-Rodríguez, et al. 2019. CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity. Molecular Metabolism, 75-85. |
30104247 | Seoane-Collazo, P., et al. 2018. SF1-Specific AMPKα1 deletion protects against diet-induced obesity. Diabetes, 2213-2226. |
30018241 | Liñares-Pose, L., et al. 2018. Genetic targeting of GRP78 in the VMH improves obesity independently of food intake. Genes, 357. |
29562231 | Devram S. Ghorpade, et al. 2018. Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance. Nature, 673-677. |
29478099 | Stadion, M., et al. 2018. Increased Ifi202b/IFI16 expression stimulates adipogenesis in mice and humans. Diabetologia, 1167-1179. |
28846071 | Rong X, et al. 2017. ER phospholipid composition modulates lipogenesis during feeding and in obesity. Journal of Clinical Investigation, 3640-3651. |
27634226 | Contreras C, et al. 2017. Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity. Diabetes, 87-99. |
26150485 | Zeng W, et al. 2015. Reanalysis of parabiosis of obesity mutants in the age of leptin. PNAS: USA, E3874-E3882. |
25284795 | Contreras C, et al. 2014. Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance. Cell Reports, 366-377. |
24917578 | Beiroa D, et al. 2014. GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK. Diabetes, 3346-3358. |
22692684 | Vogel H, et al. 2012. Loss of function of Ifi202b by a microdeletion on chromosome 1 of C57BL/6J mice suppresses 11β-hydroxysteroid dehydrogenase type 1 expression and development of obesity. Human Molecular Genetics, 3845-3857. |
22682225 | Haas JT, et al. 2012. Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. Cell Metabolism, 873-884. |
22315316 | Martínez de Morentin PB, et al. 2012. Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase. Diabetes, 807-817. |
Diabetes | ||
PMID | Publication | |
33449689 | BT Milliken, et al. 2021. Design and Evaluation of Peptide Dual-Agonists of GLP-1 and NPY2 Receptors for Glucoregulation and Weight Loss with Mitigated Nausea and Emesis. Journal of Medicinal Chemistry, 1127-1138. | |
27110486 | Okada, K., et al. 2016. Thioesterase superfamily member 1 suppresses cold thermogenesis by limiting the oxidation of lipid droplet-derived fatty acids in brown adipose tissue. Molecular Metabolism, 340-351. | |
26909312 | Quiñones M, et al. 2015. Hypothalamic CaMKKβ mediates glucagon anorectic effect and its diet-induced resistance. Molecular Metabolism, 961-970. |
Insulin Resistance | ||
PMID | Publication | |
31952989 | HP Nguyen, et al. 2020. Aifm2, a NADH Oxidase, Supports Robust Glycolysis and Is Required for Cold- and Diet-Induced Thermogenesis. Molecular Cel, 600-617. |
Pancreas
Pancreatitis | ||
PMID | Publication | |
27650499 | Xiao X, et al. 2016. A Carboxyl Ester Lipase (CEL) Mutant Causes Chronic Pancreatitis by Forming Intracellular Aggregates That Activate Apoptosis. Journal of Biological Chemistry, 23224-23236. | |
23955596 | Witt H, et al. 2013. Variants in CPA1 are strongly associated with early onset chronic pancreatitis. Nature Genetics, 1216-1220. | |
22942235 | Beer S, et al. 2012. Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk. Gut, 1616-1624. |
PNLIP | ||
PMID | Publication | |
25862608 | Szabó A, et al. 2015. A novel mutation in PNLIP causes pancreatic triglyceride lipase deficiency through protein misfolding. Biochmica et Biophysica Acta, 1372-1379. |
Pulmonary
Pulmonary | ||
PMID | Publication | |
38605139 | Schofield, L.G., et al. 2024. The soluble (pro)renin receptor promotes a preeclampsia-like phenotype both in vitro and in vivo. Hypertension Research, . | |
38099297 | Al-Mutairy EA, et al. 2023. Wild-type S100A3 and S100A13 restore calcium homeostasis and mitigate mitochondrial dysregulation in pulmonary fibrosis patient-derived cells. Frontier in Cells and Developmental Biology, 1282868. | |
36859533 | B Jiménez-Gómez, et al. 2023. Transgenic NADH dehydrogenase restores oxygen regulation of breathing in mitochondrial complex I-deficient mice. Nature Communications, 1172. | |
35833903 | HC Do-Umehara, et al. 2022. Suppression of Allergic Asthma by Loss of Function of Miz1-mediated Th1 Skewing. American Journal of Respiratory Cell and Molecular Biology, 346-359. | |
35714602 | Wang C, et al. 2022. Triangulating variation in the population to define mechanisms for precision management of genetic disease. Structure, 1190-1207. | |
30753450 | F Anglès, et al. 2019. HDAC inhibitors rescue multiple disease-causing CFTR variants. Human Molecular Genetics, 1982-2000. | |
29924966 | Hutt, D.M., et al. 2018. A proteomic variant approach (ProVarA) for personalized medicine of inherited and somatic disease. Journal of Molecular Biology, 2951-2973. | |
28874464 | Cerniello FM, et al. 2017. MAS1 Receptor Trafficking Involves ERK1/2 Activation Through a β-Arrestin2-Dependent Pathway. Hypertension, 982-989. | |
27913421 | Yanagisawa H, et al. 2017. Role of IL-17A in murine models of COPD airway disease. American Journal of Physiology. Lung Cellular and Molecular Physiology, L122-L130. | |
26109638 | Hashimoto M, et al. 2015. TGF-β-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease. Journal of Immunology, 1182-1190. | |
23371060 | Allen-Gipson DS, et al. 2013. Smoke extract impairs adenosine wound healing: implications of smoke-generated reactive oxygen species. American Journal of Respiratory Cell and Molecular Biology, 665-673. |
Lung Development | ||
PMID | Publication | |
38844539 | Mooers, EA, et al. 2024. Aberrant PGC-1α signaling in a lamb model of persistent pulmonary hypertension of the newborn. Pediatric research, . | |
23499839 | Berkelhamer SK, et al. 2013. Developmental differences in hyperoxia-induced oxidative stress and cellular responses in the murine lung. Free Radical Biology and Medicine, 51-60. |
Lung Inflammation | ||
PMID | Publication | |
34899681 | J Yang, et al. 2021. miR-221-5p-Mediated Downregulation of JNK2 Aggravates Acute Lung Injury. Frontiers in Immunology, 700933. | |
28620381 | Brazee PL, et al. 2017. FXYD5 Is an Essential Mediator of the Inflammatory Response during Lung Injury. Frontiers in Immunology, 623. |
Pulmonary Disease | ||
PMID | Publication | |
39189851 | Trujillo, G., et al. 2024. Toll-like Receptor 9 Inhibition Mitigates Fibroproliferative Responses in Translational Models of Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine, . | |
35998281 | Ahangari F, et al. 2022. Saracatinib, a selective Src kinase inhibitor, blocks fibrotic responses in preclinical models of pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine , 1463-1479. | |
35931677 | Y Chen, et al. 2022. Club cells employ regeneration mechanisms during lung tumorigenesis. Nature Communications, 4557. | |
27452368 | Schlingmann B, et al. 2016. Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions. Nature Communications, 12276. | |
26999599 | Fink L, et al. 2016. Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection. The Journal of Clinical Investigation, 1566-1580. | |
23136161 | Jakob P, et al. 2012. Loss of angiomiR-126 and 130a in angiogenic early outgrowth cells from patients with chronic heart failure: role for impaired in vivo neovascularization and cardiac repair capacity. Circulation, 2962-2975. | |
22634619 | Luzina IG, et al. 2012. Full-length IL-33 promotes inflammation but not Th2 response in vivo in an ST2-independent fashion. Journal of Immunology, 403-410. |
Renal
PMID | Publication |
32240312 | YJ Jung, et al. 2020. SIRT2 is involved in cisplatin-induced acute kidney injury through regulation of mitogen-activated protein kinase phosphatase-1. Nephrology, Dialysis, Transplantation, 1145-1156. |
30385718 | Jaykumar, A.B., et al. 2018. Role of Alström syndrome 1 in the regulation of blood pressure and renal function. JCI Insight, e95076. |
27551042 | Caceres PS, et al. 2016. Vesicle-associated Membrane Protein 3 (VAMP3) Mediates Constitutive Trafficking of the Renal Co-transporter NKCC2 in Thick Ascending Limbs: ROLE IN RENAL FUNCTION AND BLOOD PRESSURE. Journal of Biological Chemistry, 22063-22073. |
22977238 | Ares GR, et al. 2012. Dynamin2, clathrin, and lipid rafts mediate endocytosis of the apical Na/K/2Cl cotransporter NKCC2 in thick ascending limbs. Journal of Biological Chemistry, 37824-37834. |
22896039 | Hong NJ, et al. 2012. NADPH oxidase 4 mediates flow-induced superoxide production in thick ascending limbs. American Journal of Physiology. Renal Physiology, F1151-F1156. |
22875785 | Massey KJ, et al. 2012. Angiotensin II stimulates superoxide production in the thick ascending limb by activating NOX4. American Journal of Physiology. Cell Physiology, C781-789. |
Renal Injury | ||
PMID | Publication | |
26911537 | Jung M, et al. 2016. Macrophage-derived Lipocalin-2 contributes to ischemic resistance mechanisms by protecting from renal injury. Scientific Reports, 21950. |
Reproductive System
Fertility | ||
PMID | Publication | |
25340710 | Swiderski RE, et al. 2014. A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling. PLoS Genetics, e1004689. |
Hormones | ||
PMID | Publication | |
30348767 | Roa, J., et al. 2018. Metabolic regulation of female puberty via hypothalamic AMPK–kisspeptin signaling. PNAS: USA, E10758-E10767. | |
30304681 | González-García, I., et al. 2018. Estradiol regulates energy balance by ameliorating hypothalamic ceramide-induced ER stress. Cell Reports, 413-423. | |
28683288 | Martínez-Sánchez N, et al. 2017. Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Cell Matabolism, 212-229. | |
28218624 | Ahmed K, et al. 2017. Loss of microRNA-7a2 induces hypogonadotropic hypogonadism and infertility. Journal of Clinical Investigation, 1061-1074. | |
27913573 | Martínez-Sánchez N, et al. 2017. Thyroid hormones induce browning of white fat. Journal of Endocrinology, 351-362. | |
24856932 | Martínez de Morentin PB, et al. 2014. Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK. Cell Metabolism, 41-53. |
RNA/mRNA/miRNA/shRNA
PMID | Publication |
38907037 | Mathis, N, et al. 2024. Machine learning prediction of prime editing efficiency across diverse chromatin contexts. Nature biotechnology, . |
37296170 | H Vatandaslar, et al. 2023. In vivo PAR-CLIP (viP-CLIP) of liver TIAL1 unveils targets regulating cholesterol synthesis and secretion. Nature Communications, 3386. |
36646933 | N Mathis, et al. 2023. Predicting prime editing efficiency and product purity by deep learning. Nature Biotechnology, 1151-1159. |
32497496 | X Li, et al. 2020. High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down. Molecular Cell, 167-179. |
32497496 | X Li, et al. 2020. High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down. Molecular Cell, 167-179. |
32143184 | J Latorre, et al. 2020. Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes. EBioMedicine, 102697. |
24355758 | Sehgal A, et al. 2014. Tissue-specific gene silencing monitored in circulating RNA. RNA, 143-149. |
16258535 | Krutzfeldt J, et al. 2005. Silencing of microRNAs in vivo with 'antagomirs'. Nature, 685-689. |
Vaccine
PMID | Publication |
37830821 | JA Misplon, et al. 2023. Adenoviral-vectored universal influenza vaccines administered intranasally reduce lung inflammatory responses upon viral challenge 15 months post-vaccination. Journal of Virology, e0067423. |
36377872 | OE Harwood, et al. 2022. Transient T Cell Expansion, Activation, and Proliferation in Therapeutically Vaccinated Simian Immunodeficiency Virus-Positive Macaques Treated with N-803. Journal of Virology, e0142422. |
36190241 | AL Ellis-Connell, et al. 2022. Control of Simian Immunodeficiency Virus Infection in Prophylactically Vaccinated, Antiretroviral Treatment-Naive Macaques Is Required for the Most Efficacious CD8 T Cell Response during Treatment with the Interleukin-15 Superagonist N-803. Journal of Virology, e0118522. |
35023731 | LF Barnes, et al. 2022. Analysis of Recombinant Adenovirus Vectors by Ion Trap Charge Detection Mass Spectrometry: Accurate Molecular Weight Measurements beyond 150 MDa. Analytical Chemistry, 1543-1551. |
33796119 | N Pedreño-Lopez, et al. 2021. Non-neutralizing Antibodies May Contribute to Suppression of SIVmac239 Viremia in Indian Rhesus Macaques. Frontiers in Immunology, 657424. |
33627390 | S Dhakal, et al. 2021. Effect of an Adenovirus-Vectored Universal Influenza Virus Vaccine on Pulmonary Pathophysiology in a Mouse Model. Journal of Virology, e02359-20. |
33441339 | K Sangare, et al. 2021. The immunological impact of adenovirus early genes on vaccine-induced responses in mice and nonhuman primates. Journal of Virology, e02253-20. |
31315990 | SA Abdulhaqq, et al. 2019. Vaccine-Mediated Inhibition of the Transporter Associated with Antigen Processing Is Insufficient To Induce Major Histocompatibility Complex E-Restricted CD8+ T Cells in Nonhuman Primates. Journal of Virology, e00592-19. |
30037481 | Price, G.E., et al. 2018. Reduction of influenza virus transmission from mice immunized against conserved viral antigens is influenced by route of immunization and choice of vaccine antigen. Vaccine, 4910-4918. |
29875239 | , et al. 2018. Mamu-B*17+ Rhesus Macaques Vaccinated with env, vif, and nef Manifest Early Control of SIVmac239 Replication. Journal of Virology, e00690-18. |
27055234 | García M, et al. 2016. Age Dependence of Immunity Induced by a Candidate Universal Influenza Vaccine in Mice. PLoS One, . |
26374823 | Gabitzsch ES, et al. 2015. The generation and analyses of a novel combination of recombinant adenovirus vaccines targeting three tumor antigens as an immunotherapeutic. Oncotarget, 31344-31359. |
26355094 | Malczyk AH, et al. 2015. A Highly Immunogenic and Protective Middle East Respiratory Syndrome Coronavirus Vaccine Based on a Recombinant Measles Virus Vaccine Platform. Journal of Virology, 11654-11667. |
26292326 | Martins MA, et al. 2015. Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8+ T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after Infection. Journal of Virology, 10802-10820. |
26018172 | Volz A, et al. 2015. Protective Efficacy of Recombinant Modified Vaccinia Virus Ankara Delivering Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein. Journal of Virology, 8651-8656. |
24741098 | Martins MA, et al. 2014. Vaccination with Gag, Vif, and Nef gene fragments affords partial control of viral replication after mucosal challenge with SIVmac239. Journal of Virology, 7493-7516. |
24509082 | Subramanian M, et al. 2014. An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo. Journal of Clinical Investigation, 1296-1308. |
24328381 | Barlow PG, et al. 2014. Antiviral potential of cathelicidins. Future Microbiology, 55-73. |
23777453 | Rivers K, et al. 2013. Comparison of the effectiveness of antibody and cell-mediated immunity against inhaled and instilled influenza virus challenge. Virology Journal, 198. |
23596321 | Eyles JE, et al. 2013. Nonreplicating vaccines can protect african green monkeys from the memphis 37 strain of respiratory syncytial virus. The Journal of Infectious Diseases, 319-329. |
23103198 | Bright H, et al. 2012. The efficacy of HSV-2 vaccines based on gD and gB is enhanced by the addition of ICP27. Vaccine, 7529-7535. |
23041546 | Gabitzsch ES, et al. 2012. Control of SIV infection and subsequent induction of pandemic H1N1 immunity in rhesus macaques using an Ad5 [E1-, E2b-] vector platform. Vaccine, 7265-7270. |
23023123 | Mudd PA, et al. 2012. Vaccine-induced CD8+ T cells control AIDS virus replication. Nature, 129-133. |
22586427 | Thomson CA, et al. 2012. Pandemic H1N1 Influenza Infection and Vaccination in Humans Induces Cross-Protective Antibodies that Target the Hemagglutinin Stem. Frontiers in Immunology, 87. |
HIV | ||
PMID | Publication | |
30541854 | MA Martins, et al. 2019. The Frequency of Vaccine-Induced T-Cell Responses Does Not Predict the Rate of Acquisition after Repeated Intrarectal SIVmac239 Challenges in Mamu-B*08+ Rhesus Macaques. Journal of Virology, e01626-18. |
SARS-CoV-2 | ||
PMID | Publication | |
34162739 | A Tscherne, et al. 2021. Immunogenicity and efficacy of the COVID-19 candidate vector vaccine MVA-SARS-2-S in preclinical vaccination. PNAS: USA, . |
Tuberculosis | ||
PMID | Publication | |
27317453 | Kaveh DA, et al. 2016. Parenteral adenoviral boost enhances BCG induced protection, but not long term survival in a murine model of bovine TB. Vaccine, 4003-4011. |
Viruses
HPV/Cancer | ||
PMID | Publication | |
26337747 | Rice AE, et al. 2015. An HPV-E6/E7 immunotherapy plus PD-1 checkpoint inhibition results in tumor regression and reduction in PD-L1 expression. Cancer Gene Therapy, 454-462. |
Biotherapeutics | ||
PMID | Publication | |
35449595 | TW Powers, et al. 2022. Identification of Recombinant Chimpanzee Adenovirus C68 Degradation Products Detected by AEX-HPLC. Frontiers in Bioengineering and Biotechnology, 753481. |
Herpes Simplex Virus | ||
PMID | Publication | |
36692302 | JH Arbuckle, et al. 2023. Deletion of the Transcriptional Coactivator HCF-1 In Vivo Impairs the Removal of Repressive Heterochromatin from Latent HSV Genomes and Suppresses the Initiation of Viral Reactivation. mBio, e0354222. | |
30541854 | MA Martins, et al. 2019. The Frequency of Vaccine-Induced T-Cell Responses Does Not Predict the Rate of Acquisition after Repeated Intrarectal SIVmac239 Challenges in Mamu-B*08+ Rhesus Macaques. Journal of Virology, e01626-18. | |
30541854 | MA Martins, et al. 2019. The Frequency of Vaccine-Induced T-Cell Responses Does Not Predict the Rate of Acquisition after Repeated Intrarectal SIVmac239 Challenges in Mamu-B*08+ Rhesus Macaques. Journal of Virology, e01626-18. | |
26292326 | Martins MA, et al. 2015. Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8+ T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after Infection. Journal of Virology, 10802-10820. | |
24741098 | Martins MA, et al. 2014. Vaccination with Gag, Vif, and Nef gene fragments affords partial control of viral replication after mucosal challenge with SIVmac239. Journal of Virology, 7493-7516. | |
24578133 | Xie X, et al. 2014. The basic domain of HIV-tat transactivating protein is essential for its targeting to lipid rafts and regulating fibroblast growth factor-2 signaling in podocytes isolated from children with HIV-1-associated nephropathy. Journal of American Society of Nephrology, 1800-1813. | |
23023123 | Mudd PA, et al. 2012. Vaccine-induced CD8+ T cells control AIDS virus replication. Nature, 129-133. |
immune Response | ||
PMID | Publication | |
32943673 | G Hotter, et al. 2020. The influenza virus NS1A binding protein gene modulates macrophages response to cytokines and phagocytic potential in inflammation. Scientific Reports, 15302. |
Infection | ||
PMID | Publication | |
25190799 | Tam JC, et al. 2014. Intracellular sensing of complement C3 activates cell autonomous immunity. Science, 1256070. |
SARS-CoV-2 | ||
PMID | Publication | |
34452363 | S Halwe, et al. 2021. Intranasal Administration of a Monoclonal Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection. Viruses, 1498. | |
32616594 | L Sauerhering, et al. 2020. Cyclophilin inhibitors restrict Middle East respiratory syndrome coronavirus via interferon-λ in vitro and in mice. The European Respiratory Journal, 1901826. |
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