Anti-TrpM6 Antibody Biotin Conjugate (N470/22)

Name: Anti-TrpM6 Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-464-BTN
Price: 543.0 USD
Availability: InStock

Our mouse TrpM6 biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone N470/22. It detects human TrpM6 and is purified by Protein A chromatography. Works in ELISA, ICC, WB.

Anti-TrpM6 Antibody Biotin Conjugate

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Species Reactivity

Human

Applications

ELISA, ICC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 75-464-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

TrpM6

Scientific Background

Transient receptor potential cation channel subfamily M member 6 or TrpM6 is encoded by the gene TRPM6. TrpM6 is a member of the transient receptor potential ion channel family and acts as a serine/threonine-protein kinase. TrpM6 has an essential function in magnesium transport and is involved with magnesium absorption in the gut and kidney. TRPM6 is primarily expressed in the kidney, colon, GI tract and placenta kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N470/22

Isotype

IgG2a

Applications

ELISA, ICC, WB

Host Species

Mouse

Gene Name

TRPM6 CHAK2

Molecular Weight

240 kDa

Immunogen

Fusion Protein Amino acids 1258-1480 (cytoplasmic C-terminus) of human TrpM6 (accession number Q9BX84) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

CHAK2; TrpM6; HOMG; Transient receptor potential cation channel subfamily M member 6; HOMG1; Melastatin-related TRPcation channel 6; HSH; Channel kinase 2; melastatin-related TRP cation channel 6

UniProt ID

Q9BX84
UniProt Summary: Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. Crucial for Mg(2+) homeostasis. Has an important role in epithelial Mg(2+) transport and in the active Mg(2+) absorption in the gut and kidney. However, whether TRPM6 forms functional homomeric channels by itself or functions primarily as a subunit of heteromeric TRPM6-TRPM7 channels, is still under debate.

NCBI Gene ID

140803

Shipping

Shipped on ice packs

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Anti-TrpM6 Antibody Biotin Conjugate (N470/22)

SKU: 75-464-BTN

Product Details

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