Custom Peptide Synthesis

Aves Labs provides researchers with custom, in-house peptide synthesis at competitive prices. We can also synthesize peptides with modified amino acids, including phosphorylated residues, biotinylated residues, nitrosylated residues, and more.

Click here to view publications using our custom services!

Options

  • Scales of Synthesis
    We can produce milligram to gram quantities of peptide.
  • Purities
    Although we recommend >70% purity levels for most antibody production purposes, we can further purify your peptides to >98% for other types of applications.
  • Chemical Modifications
    We can modify your peptide in virtually any way you desire, including phosphorylation, amidation, acetylation, methylation, nitrosylation, cyclization, and more.

Our Process Yields Anti-Peptide Antibodies That Work

The most important step in the process of anti-peptide production is the choice of peptide sequence. Aves offers over twenty years of experience in this field, in that time developing thousands of successful anti-peptide antibodies for diverse customers.

Our Immunogenicity Algorithm® identifies sequences that involve analysis of hydrophilicity, chain flexibility, surface probability and the presence or absence of problematic and desirable residues in particular positions within the peptide. We check our peptides for potential sites of post-translational modification, which may reduce their binding properties. Finally, we run our peptides against a chicken database to avoid peptides with high homologies with endogenous chicken proteins.

We guarantee that the peptides we identify will be immunogenic and that the antibodies produced against them will recognize the cognate sequence. We cannot guarantee that these anti-peptide antibodies will recognize the native protein. This may be due to an unexpected post-translational modification within the sequence or to protein folding events which may hide the epitope.


Publications Using Our Custom Services

PMID Publication
38134511 Ochwoto, M, et al. 2023. Cytoarchitecture of ex vivo midgut cultures of unfed Ixodes scapularis infected with a tick-borne flavivirus. Ticks and Tick-Borne Diseases, 102301.
38134511 Ochwoto, M., et al. 2023. Cytoarchitecture of ex vivo midgut cultures of unfed Ixodes scapularis infected with a tick-borne flavivirus. Ticks Tick Borne Diseases, 102301.
37981423 Tahara, U, et al. 2023. Keratinocytes of the Upper Epidermis and Isthmus of Hair Follicles Express Hemoglobin mRNA and Protein. The Journal of investigative dermatology, 2346-2355.e10.
37720106 Rose, K.P., et al. 2023. Spatially distinct otic mesenchyme cells show molecular and functional heterogeneity patterns before hearing onset. iScience, 107769.
36781220 Gregoriou, G.C., et al. 2023. Opioid withdrawal abruptly disrupts amygdala circuit function by reducing peptide actions. Journal of Neuroscience, 1668-1681.
36448839 Castro-Córdova, P., et al. 2023. Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions. Infection and Immunity, e0047622.
35379362 Winkler, C.W., et al. 2022. Zika virus vertical transmission in interferon receptor1-antagonized Rag1−/− mice results in postnatal brain abnormalities and clinical disease. Acta Neuropathology Communications, 46.
35326270 Brašić, J.R., et al. 2022. Fragile X Mental Retardation Protein and cerebral expression of metabotropic glutamate receptor subtype 5 in men with fragile X syndrome: A pilot study. Brain Science, 314.
35182405 Nonnecke, E.B., et al. 2022. Human intelectin‐2 (ITLN2) is selectively expressed by secretory Paneth cells. FASEB Journal, e22200.
35029299 Baldicano, A.K., et al. 2022. Retinal ganglion cells expressing CaM kinase II in human and nonhuman primates. Journal of Comparative Neurology, 1470-1493.
34622958 Nasir‐Ahmad, S., et al. 2022. Satb1 expression in retinal ganglion cells of marmosets, macaques, and humans. Journal of Comparative Neurology, 923-940.
34468815 Ton, T.V.T., et al. 2021. Cobalt-induced oxidative stress contributes to alveolar/bronchiolar carcinogenesis in B6C3F1/N mice. Archives of Toxicology, 3171-3190.
34145348 Nonnecke, E.B., et al. 2021. Human intelectin-1 (ITLN1) genetic variation and intestinal expression. Scientific Reports, 12889.
32725281 Kahng, S.J., et al. 2020. Carbon nanotube-based thin-film resistive sensor for point-of-care screening of tuberculosis. Biomedical Microdevices, 50.
32255763 Carrisoza-Gaytan, R., et al. 2020. Intercalated cell BKα subunit is required for flow-induced K+ secretion. JCI Insight, e130553.
32179647 Yadav, P.K., et al. 2020. Thioredoxin regulates human mercaptopyruvate sulfurtransferase at physiologically-relevant concentrations. Journal of Biological Chemistry, 6299-6311.
32099918 Harper, M.M., et al. 2020. Identification of chronic brain protein changes and protein targets of serum auto-antibodies after blast-mediated traumatic brain injury. Heliyon, e03374.
31363993 LeBlanc, B.M., et al. 2019. Structural properties and cellular expression of AfrLEA6, a group 6 late embryogenesis abundant protein from embryos of Artemia franciscana. Cell Stress Chaperones, 979-990.
31275378 Chavez-Cortez, E.G., et al. 2019. Production and evaluation of an avian IgY immunotoxin against CD133+ for treatment of carcinogenic stem cells in malignant glioma: IgY immunotoxin for the …. Journal of Oncology, 2563092.
30973903 Gerhart, J., et al. 2019. Rhabdomyosarcoma and Wilms tumors contain a subpopulation of noggin producing, myogenic cells immunoreactive for lens beaded filament proteins. PLoS One, e0214758.
30161155 Zhao, L., et al. 2018. Dynamic and tissue-specific proteolytic processing of chemerin in obese mice. PLoS One, e0202780.
29973268 Zhao, L., et al. 2018. Chemerin 156F, generated by chymase cleavage of prochemerin, is elevated in joint fluids of arthritis patients. Arthritis Research and Therapy, 132.
29903915 Emerman, A.B., et al. 2018. The RNA-binding complex ESCRT-II in Xenopus laevis eggs recognizes purine-rich sequences through its subunit, Vps25. Journal of Biological Chemistry, 12593-12605.
29760438 Kotila, T., et al. 2018. Structural basis of actin monomer re-charging by cyclase-associated protein. Nature Communications, 1892.
29505961 Patel, N.S., et al. 2018. Identification of new PDE9A isoforms and how their expression andásubcellular compartmentalization in the brain change across the life span. Neurobiology of Aging, 217-234.
28775298 Winkler, C.W., et al. 2017. Sexual and Vertical Transmission of Zika Virus in anti-interferon receptor-treated Rag1-deficient mice. Scientific Reports, 7176.

Ready to Get Started?

For questions or a quote from one of our scientists, submit your project details below. We will respond within two business days. If you require immediate assistance, call us at (800) 824-8540.