Tools such as neuronal tracers, amyloid and neurodegeneration stains, synaptic vesicle dyes and fluorescent calcium indicators are all key reagents in a neuroscientist's toolbox. These tools provide unique, valuable insights into neural connections, pathways and neurodegenerative diseases. They may also be used in tandem with our antibodies in immunohistochemical and immunofluorescent applications to achieve multi-dimensional neuroanatomical tracing.
Antibodies Inc. offers a full range of neuronal dyes and tracing reagents such as our highly-cited Fluoro-Jade B and C that stain and identify neurons undergoing degeneration which is crucial for studying neurodegenerative diseases like Alzheimer's and Parkinson's disease.
Others such as SynaptoGreen™ and SynaptoRed™ nerve terminal dyes can be used to specifically track the dynamics of synaptic vesicles, providing insights into neurotransmitter release and recycling.
We also feature a variety of tracers including lectins and dextrans conjugated to CF® fluorescent dyes across the spectrum.
Anterograde & Retrograde Axonal Tracers
Neuronal tracers such as Hydroxystilbamidine (aka Fluoro-Gold™), Cholera Toxin Subunit B, PHA-L and Dextrans are widely used to map the connections and pathways of neurons.
Amyloid Stains & Neurodegeneration Dyes
Amyloid stains and neurodegeneration dyes such as Fluoro-Jade and Congo Red are crucial tools used to identify and study abnormal protein aggregates associated with neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, and other tauopathies.
Nerve Terminal Dyes
Nerve terminal dyes such as SynaptoGreen™ and SynaptoRed™ are essential tools for following synaptic activity by staining synaptic vesicles.
Ion Channel Neurotoxins & Probes
Ion channel neurotoxins and probes are valuable tools for studying ion channel structure, function, and pharmacology.
Fluorescent Ca2+ and other Ion Indicators
Calcium imaging is widely used to measure neuronal activity.
Lectins
Lectins are carbohydrate binding proteins that recognize specific sugar moieties on glycoproteins. The presence and distribution of these targets vary between cell types and tissues.
Lipid Tracers
Polar lipid fluorescent dyes are useful for visualizing and studying lipid-rich cellular compartments, like the endoplasmic reticulum and mitochondria, in live and fixed cells.
Methotrexate Dye Conjugates
Methotrexate conjugates are widely used in studying how drugs bind to their target receptors, antimetabolite resistance, and spontaneous gene amplification.
Myelin Biology
Myelin stains such as our Black Gold II work to localise myelin, both individual fibres and tracts, and co-localize cell bodies via Toluidine Blue counter stain.
Nissl Stains
Nissl Stains such as NisslFluor™ Red and NisslFluor™ Orange are widely used to stain the soma and proximal parts of the dendrites, cytoplasm, and nuclei of neurons.
Quenchers
Quenchers such as SCAS and ADVASEP-7 are used to reduce background fluorescence when using fixable AM dyes, SynaptoGreen™ and SynaptoRed™ dyes.
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