Immunoblot against extracts of COS cells transiently transfected with HA-tagged TrpM6 or untagged Kv2.1 plasmid probed with N470/22 (left) or rabbit anti-HA (right)..
TrpM6 (Transient receptor potential cation channel subfamily M member 6) (Melastatin-related TRP
cation channel 6) (Channel kinase 2)
Transient receptor potential cation channel subfamily M member 6 or TrpM6 is encoded by the gene TRPM6. TrpM6 is a member of the transient receptor potential ion channel family and acts as a serine/threonine-protein kinase. TrpM6 has an essential function in magnesium transport and is involved with magnesium absorption in the gut and kidney. TRPM6 is primarily expressed in the kidney, colon, GI tract and placenta kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia.
Fusion protein amino acids 1258-1480 (cytoplasmic C-terminus) of human TrpM6 (also known as Transient receptor potential cation channel subfamily M member 6, Melastatin-related TRP cation channel 6, Channel kinase 2 and CHAK2, accession number Q9BX84)
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