Anti-Cav2.3 Recombinant Chicken Chimeric mAb Biotin Conjugate (N493/22)
Our chicken Cav2.3 biotin conjugate recombinant antibody from Aves Labs is produced in-house from clone N493/22. It detects human, mouse, and rat Cav2.3 and is purified by affinity chromatography. Works in ELISA, ICC, IHC, WB.
Anti-Cav2.3 Recombinant Chicken Chimeric mAb Biotin Conjugate
Cav2.3, encoded by CACNA1E, is a member of the R-type voltage-gated calcium channels that mediate calcium influx in response to membrane depolarization. It is predominantly expressed in neurons, where it contributes to dendritic excitability, neurotransmitter release, and synaptic integration. Structurally, Cav2.3 consists of the pore-forming α1E subunit, composed of four homologous domains with six transmembrane segments each, forming the channel’s voltage-sensing and ion-conducting regions. Unlike L-, N-, or P/Q-type channels, Cav2.3 exhibits unique pharmacological sensitivity and activation kinetics, allowing it to fine-tune neuronal signaling. Dysregulation of Cav2.3 activity has been implicated in epileptogenesis, pain modulation, and neurodegenerative diseases, making it a critical target for understanding calcium-dependent neuronal processes and potential therapeutic interventions.
Purified by affinity chromatography
Lot dependent: provided at 0.3-0.5 mg/mL
Recombinant
N493/22
IgY
ELISA, ICC, IHC, WB
Chicken
Cacna1e
257 kDa
Recombinant Protein Amino acids 956-1033 (ID I-II cytoplasmic loop) of mouse Cav2.3 (also known as voltage-dependent R-type calcium channel subunit alpha-1E, Cacna1e, accession number Q61290) produced recombinantly in E.Coli.
Mouse
Human, Mouse, Rat
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone N493/22 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N493/22 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.
1X PBS, 0.05% Sodium Azide pH 7.4
Biotin
No cross-reactivity reported
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Q61290
UniProt Summary: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells. They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.
777
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