Anti-Cav alpha2 delta2 Recombinant Chicken Chimeric mAb Biotin Conjugate (N492/39)

Name: Anti-Cav alpha2 delta2 Recombinant Chicken Chimeric mAb Biotin Conjugate
Brand: Aves Labs
SKU: 78-530-BTN
Price: 562.0 USD
Availability: InStock

Our chicken Cav alpha2 delta2 biotin conjugate recombinant antibody from Aves Labs is produced in-house from clone N492/39. It detects human, mouse, and rat Cav alpha2 delta2 and is purified by affinity chromatography. Works in ELISA, ICC, IHC, WB.

Anti-Cav alpha2 delta2 Recombinant Chicken Chimeric mAb Biotin Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

Trial Size

SKU: 78-530-BTN

Volume: 200 µL

Variant

Price:

$562.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Cav alpha2 delta2

Scientific Background

Cav α2δ2 is an auxiliary subunit of voltage-gated calcium channels that modulates channel trafficking, gating, and pharmacological properties. Encoded by the CACNA2D2 gene, this glycoprotein is synthesized as a single precursor that is post-translationally cleaved into the extracellular α2 and membrane-anchored δ2 subunits, linked by disulfide bonds. Cav α2δ2 enhances calcium current density by promoting the proper trafficking of pore-forming Cavα1 subunits to the plasma membrane and stabilizing them at synaptic sites. It plays a key role in neurotransmitter release, synaptic plasticity, and neuronal excitability. Altered expression or mutation of CACNA2D2 has been associated with neurological disorders, including epilepsy, cerebellar ataxia, and certain cancers, underscoring its importance in calcium channel regulation and disease pathophysiology.

Format

Purified by affinity chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Recombinant

Clone

N492/39

Isotype

IgY

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Gene Name

Cacna2d2

Molecular Weight

130 kDa

Immunogen

Recombinant Protein Amino acids 61-197 (extracellular domain) of mouse Cav alpha2 delta2 (also known as voltage-dependent R-type calcium channel subunit alpha-2/delta-2, Cacna2d2, accession number Q6PHS9) produced recombinantly in E.Coli.

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone N492/39 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N492/39 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Cacna2d; voltage-dependent R-type calcium channel subunit alpha-2/delta-2; mKIAA0558; torpid; alpha 2 delta calcium channel subunit; ducky; protein ducky; Cacna2d2

UniProt ID

Q6PHS9
UniProt Summary: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.

NCBI Gene ID

56808

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Anti-Cav alpha2 delta2 Recombinant Chicken Chimeric mAb Biotin Conjugate (N492/39)

SKU: 78-530-BTN

Product Details

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