Anti-Cav2.3 Recombinant Chicken Chimeric mAb (BSA and Azide free) (N493/22)

Name: Anti-Cav2.3 Recombinant Chicken Chimeric mAb (BSA and Azide free)
Brand: Aves Labs
SKU: 78-531-CF
Price: 510.0 USD
Availability: InStock

Our chicken Anti-Cav2.3 recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone N493/22. It detects human, mouse, and rat Cav2.3, and is purified by affinity chromatography. It is great for use in ELISA, ICC, IHC, WB.

Anti-Cav2.3 Recombinant Chicken Chimeric mAb (BSA and Azide free)

Click on image to zoom

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

550

594

650

Go to Full Product Details

Data Sheet

SKU: 78-531-CF

Volume: 100 µL

Variant

Price:

$510.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Cav2.3

Scientific Background

Cav2.3, encoded by CACNA1E, is a member of the R-type voltage-gated calcium channels that mediate calcium influx in response to membrane depolarization. It is predominantly expressed in neurons, where it contributes to dendritic excitability, neurotransmitter release, and synaptic integration. Structurally, Cav2.3 consists of the pore-forming α1E subunit, composed of four homologous domains with six transmembrane segments each, forming the channel’s voltage-sensing and ion-conducting regions. Unlike L-, N-, or P/Q-type channels, Cav2.3 exhibits unique pharmacological sensitivity and activation kinetics, allowing it to fine-tune neuronal signaling. Dysregulation of Cav2.3 activity has been implicated in epileptogenesis, pain modulation, and neurodegenerative diseases, making it a critical target for understanding calcium-dependent neuronal processes and potential therapeutic interventions.

Format

Purified by affinity chromatography

Concentration

1 mg/mL

Clonality

Recombinant

Clone

N493/22

Isotype

IgY

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Gene Name

Cacna1e

Molecular Weight

257 kDa

Excitation / Emission

Unconjugated

Immunogen

Recombinant protein amino acids 956-1033 (ID I-II cytoplasmic loop) of mouse Cav2.3 (also known as voltage-dependent R-type calcium channel subunit alpha-1E, Cacna1e, accession number Q61290) produced recombinantly in E.Coli.

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone N493/22 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N493/22 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and buffer exchanged into 1X PBS.

Buffer

PBS

Conjugate

Unconjugated, Carrier Free

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

voltage-dependent R-type calcium channel subunit alpha-1E, Cacna1e

Shipping

Shipped on ice packs

Recover password

Create my account

Anti-Cav2.3 Recombinant Chicken Chimeric mAb (BSA and Azide free) (N493/22)

SKU: 78-531-CF

Product Details

Bulk Order Anti-Cav2.3 Recombinant Chicken Chimeric mAb (BSA and Azide free)

Related Products

Recently Viewed