Anti-GABA-A-R-Alpha2 Antibody Biotin Conjugate (N399/19)

Name: Anti-GABA-A-R-Alpha2 Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-384-BTN
Price: 543.0 USD
Availability: InStock

Our mouse GABA-A-R-Alpha2 biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone N399/19. It detects mouse and rat GABA-A-R-Alpha2 and is purified by Protein A chromatography. KO validated. Works in ELISA, IHC, ICC, WB.

Anti-GABA-A-R-Alpha2 Antibody Biotin Conjugate

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Species Reactivity

Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

KO Validated

SKU: 75-384-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

GABA-A-R-Alpha2

Scientific Background

Gamma-aminobutyric acid receptor subunit alpha-2 or GABA AR-Alpha2 is encoded by the gene GABRA2. GABAA receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR alpha 5 is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR-Alpha2 is primarily expressed in brain at the cell junction, synapse,and the postsynaptic cell membrane. Diseases associated with GABRA2 include Alcohol Dependence and Alcohol Use Disorder.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N399/19

Isotype

IgG1

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Gabra2 Gabra-2

Molecular Weight

55 kDa

Immunogen

Fusion Protein Amino acids 350-385 (cytoplasmic C-terminus) of rat GABA-A-R-Alpha2 (accession number P23576) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

Does not cross-react with GABA-A-R-Alpha1

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

GABA A receptor subunit alphα2 antibody; Gamma-aminobutyric acid receptor subunit alpha-2; GABA antibody; GABA(A receptor subunit alpha-2; GABA(A receptor subunit alphα2 antibody; GABA(A receptor subunit alpha-2 antibody; GABR A2 antibody; GABRα2 antibody; GABRA2 antibody; GABRA2 protein antibody; Gamma aminobutyric acid (GABA A receptor alphα2 antibody; Gamma aminobutyric acid A receptor alphα2 antibody; Gamma aminobutyric acid receptor alphα2 subunit antibody; Gamma aminobutyric acid receptor subunit alphα2 antibody; Gamma-aminobutyric acid receptor subunit alpha-2 antibody; GBRA2_HUMAN antibody

UniProt ID

P23576
UniProt Summary: Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission. The alpha-2 subunit exhibits synaptogenic activity together with beta-2 and very little to no activity together with beta-3, the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation.

NCBI Gene ID

2555

Shipping

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Anti-GABA-A-R-Alpha2 Antibody Biotin Conjugate (N399/19)

SKU: 75-384-BTN

Product Details

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