Anti-GABA-A-R-Alpha2 Antibody (N399/19)

Name: Anti-GABA-A-R-Alpha2 Antibody
Brand: NeuroMab
SKU: 75-384
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

KO Validated

Available Conjugates

490

550

594

650

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Clone

N399/19

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

Gabra2 Gabra-2

Molecular Weight

55 kDa

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Adult rat hippocampus immunohistochemistry.

Immunoblot against crude membranes from adult rat brain (RBM) and wild-type (WT) and GABA-A-R-Alpha2 knockout (KO) mouse brains probed with N399/19 (left) and N52A/42 (right) TC supe. Mouse brains courtesy of Uwe Rudolph (Harvard Medical School.

Whole brain immunohistochemistry.

Volume: 100 µL

Variant

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Product Details

Target

GABA-A-R-Alpha2

Target Description

Gamma-aminobutyric acid receptor subunit alpha-2 or GABA AR-Alpha2 is encoded by the gene GABRA2. GABAA receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR alpha 5 is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR-Alpha2 is primarily expressed in brain at the cell junction, synapse,and the postsynaptic cell membrane. Diseases associated with GABRA2 include Alcohol Dependence and Alcohol Use Disorder.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N399/19

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Gabra2 Gabra-2

Molecular Weight

55 kDa

Antigen

Fusion protein amino acids 350-385 (cytoplasmic C-terminus) of rat GABA-A-R-Alpha2 (accession number P23576) produced recombinantly in E. Coli

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2686910

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Does not cross-react with GABA-A-R-Alpha1

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Gamma-aminobutyric acid receptor subunit alpha-2 (GABA(A) receptor subunit alpha-2)

UniProt Details

UniProt (Human): P47869
UniProt (Immunogen Species): P23576

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Anti-GABA-A-R-Alpha2 Antibody (N399/19)

Available Conjugates

Anti-GABA-A-R-Alpha2 Antibody
SKU: 75-384

Bulk Order Anti-GABA-A-R-Alpha2 Antibody

Product Details

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Anti-GABA-A-R-Alpha2 Antibody (N399/19)

Available Conjugates

Anti-GABA-A-R-Alpha2 Antibody SKU: 75-384

Bulk Order Anti-GABA-A-R-Alpha2 Antibody

Product Details

Anti-GABA-A-R-Alpha2 Antibody
SKU: 75-384