Anti-GABA-A-R-Alpha4 Antibody Biotin Conjugate (N398A/34)

Name: Anti-GABA-A-R-Alpha4 Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-383-BTN
Price: 543.0 USD
Availability: InStock

Our mouse GABA-A-R-Alpha4 biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone N398A/34. It detects mouse and rat GABA-A-R-Alpha4 and is purified by Protein A chromatography. Works in ELISA, IHC, ICC, WB.

Anti-GABA-A-R-Alpha4 Antibody Biotin Conjugate

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Species Reactivity

Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

Trial Size

SKU: 75-383-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

GABA-A-R-Alpha4

Scientific Background

Gamma-aminobutyric acid receptor subunit alpha-4 or GABA AR alpha4 is encoded by the gene GABRA4. GABAA receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR alpha 4 is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR alpha 4 has been found to be expressed in skeletal muscle tissue, adult mammalian kidney, heart and primarily in brain at the cell junction, synapse,and the postsynaptic cell membrane. Disorders involving the GABRA4 gene include autism, Status Epilepticus and restless legs syndrome.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N398A/34

Isotype

IgG1

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Gabra4

Molecular Weight

60 kDa

Immunogen

Fusion Protein Amino acids 410-450 (cytoplasmic C-terminus) of rat GABA-A-R-Alpha4 (accession number P28471) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

Does not cross-react with other GABA-A receptor Alpha subunits

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

GABA(A receptor subunit alphα4 antibody; Gamma-aminobutyric acid receptor subunit alpha-4; GABA(A receptor subunit alpha-4 antibody; GABA(A receptor subunit alpha-4; GABR A4 antibody; GABRα4 antibodyGabra4 antibody; Gamma aminobutyric acid (GABA A receptor alphα4 antibody; Gamma aminobutyric acid A receptor alphα4 antibody; Gamma aminobutyric acid receptor alphα4 subunit antibody; Gamma aminobutyric acid receptor subunit alphα4 antibody; Gamma-aminobutyric acid receptor subunit alpha-4 antibody; GBRA4_HUMAN antibody

UniProt ID

P28471
UniProt Summary: Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). Alpha-4/GABRA4 subunit often assembles with delta or gamma-2 subunits, in combination with beta subunits. When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. GABAARs containing alpha-4 are predominantly extrasynaptic, contributing to tonic inhibition in dentate granule cells and thalamic relay neurons. Extrasynaptic alpha-4-containing GABAARs control levels of excitability and network activity. GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness.

NCBI Gene ID

140675

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Anti-GABA-A-R-Alpha4 Antibody Biotin Conjugate (N398A/34)

SKU: 75-383-BTN

Product Details

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