Anti-TASK1 Potassium Channel Antibody (N374/48)

Name: Anti-TASK1 Potassium Channel Antibody
Brand: NeuroMab
SKU: 75-357
Price: 319.0 USD
Availability: InStock

2 Citations

Our Anti-TASK1 potassium channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N374/48. It is KO validated, detects mouse and rat TASK1 potassium channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

adult rat Whole brain immunohistochemistry.

Adult rat hippocampus immunohistochemistry.

Immunoblot versus crude membranes from adult rat brain (RBM) and wild-type (WT) and TASK1 KO mouse brains probed with N374/48 (left) and N52A/42 (right) TC supe. Mouse brains courtesy of Doug Bayliss (University of Virginia).

adult rat Whole brain immunohistochemistry.

Species Reactivity

Mouse, Rat

Applications

ICC, IHC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

KO Validated

SKU: 75-357

Volume: 100 µL

Variant

Price:

$319.00

Quantity:

Product Details

Target

TASK1 potassium channel

Target Description

Potassium two pore domain channel subfamily K member 3 is encoded by the gene KCNK3. KCNK3 is a member of the two pore domain potassium channel (TC 1.A.1.8) family. KCNK3 is a pH dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from the potassium ion concentration on either side of the membrane, with it functioning as an outward rectifier when the external potassium concentration is low, and it functioning as an internal rectifier when the external potassium concentration is high. KCNK3 is expressed in the heart, lung, brain, liver, kidney, and skeletal muscle. Diseases associated with KCNK3 include Pulmonary Hypertension Primary 4 and Heritable Pulmonary Arterial Hypertension.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N374/48

Isotype

IgG2b

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnk3 Task Task1

Molecular Weight

50 kDa

Antigen

Fusion protein amino acids 251-411 (cytoplasmic C-terminus) of rat Acid-sensitive potassium channel protein TASK or TASK1 (accession number O54192) produced recombinantly in E. Coli

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2315942

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Does not cross-react with TASK3

Quality Control

Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1) (Two pore K(+) channel KT3.1)

UniProt Details

UniProt (Human): O14649
UniProt (Immunogen Species): O54912

Dadi PK, Luo B, Vierra NC, Jacobson DA. (2015), 'TASK-1 Potassium Channels Limit Pancreatic α-Cell Calcium Influx and Glucagon Secretion..' Mol Endocrinol.. 10.1210/me.2014-1321.
Dadi PK, Vierra NC, Jacobson DA. (2014), 'Pancreatic β-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance..' Endocrinology. 10.1210/en.2013-2051.

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Anti-TASK1 Potassium Channel Antibody (N374/48)

SKU: 75-357

Product Details

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