Anti-TASK1 Potassium Channel Antibody FL650 Conjugate (N374/48)

Name: Anti-TASK1 Potassium Channel Antibody FL650 Conjugate
Brand: NeuroMab
SKU: 75-357-FL650
Price: 486.0 USD
Availability: InStock

Our mouse TASK1 potassium channel FL650 conjugate monoclonal antibody from NeuroMab is produced in-house from clone N374/48. It detects mouse and rat TASK1 potassium channel and is purified by Protein A chromatography. KO validated. Works in IHC, ICC.

Anti-TASK1 Potassium Channel Antibody FL650 Conjugate

Click on image to zoom

Species Reactivity

Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

Biotin

Carrier-Free

Go to Full Product Details

Data Sheet

KO Validated

SKU: 75-357-FL650

Volume: 200 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

TASK1 potassium channel

Scientific Background

Potassium two pore domain channel subfamily K member 3 is encoded by the gene KCNK3. KCNK3 is a member of the two pore domain potassium channel (TC 1.A.1.8) family. KCNK3 is a pH dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from the potassium ion concentration on either side of the membrane, with it functioning as an outward rectifier when the external potassium concentration is low, and it functioning as an internal rectifier when the external potassium concentration is high. KCNK3 is expressed in the heart, lung, brain, liver, kidney, and skeletal muscle. Diseases associated with KCNK3 include Pulmonary Hypertension Primary 4 and Heritable Pulmonary Arterial Hypertension.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N374/48

Isotype

IgG2b

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Kcnk3 Task Task1

Molecular Weight

50 kDa

Immunogen

Fusion protein amino acids 251-411 (cytoplasmic C-terminus) of rat Acid-sensitive potassium channel protein TASK or TASK1 (accession number O54192) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2940199

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

Specificity

Does not cross-react with TASK3

Quality Control

Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Task-1; Potassium channel subfamily K member 3; Acid-sensitive potassium channel protein TASK-1; TWIK-related acid-sensitive K(+ channel 1; TWIK-related acid-sensitive K+ channel; Two pore potassium channel KT3.1; Two pore K(+ channel KT3.1; potassium channel; subfamily K; member 3

UniProt ID

O54912
UniProt Summary: K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Changes ion selectivity and becomes permeable to Na(+) ions in response to extracellular acidification. Protonation of the pH sensor His-98 stabilizes C-type inactivation conformation likely converting the channel from outward K(+)-conducting, to inward Na(+)-conducting to nonconductive state. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. Allows K(+) currents with fast-gating kinetics important for the repolarization and hyperpolarization phases of action potentials. In cerebellar granule cells, heteromeric KCNK3:KCNK9 channel may hyperpolarize the resting membrane potential to limit intrinsic neuronal excitability, but once the action potential threshold is reached, it may support high-frequency action potential firing and increased neuronal excitability. Dispensable for central chemosensory respiration i.e. breathing controlled by brainstem CO2/pH, it rather conducts pH-sensitive currents and controls the firing rate of serotonergic raphe neurons involved in potentiation of the respiratory chemoreflex. Additionally, imparts chemosensitivity to type 1 cells in carotid bodies which respond to a decrease in arterial oxygen pressure or an increase in carbon dioxide pressure or pH to initiate adaptive changes in pulmonary ventilation. In adrenal gland, contributes to the maintenance of a hyperpolarized resting membrane potential of aldosterone-producing cells at zona glomerulosa and limits aldosterone release as part of a regulatory mechanism that controls arterial blood pressure and electrolyte homeostasis. In brown adipocytes, mediates K(+) efflux that counteracts norepinephrine-induced membrane depolarization, limits Ca(2+) efflux and downstream cAMP and PKA signaling, ultimately attenuating lipid oxidation and adaptive thermogenesis.

NCBI Gene ID

29553

Shipping

Shipped on ice packs

Fluorophore Data and Guidelines: Download

Recover password

Create my account

Anti-TASK1 Potassium Channel Antibody FL650 Conjugate (N374/48)

SKU: 75-357-FL650

Product Details

Bulk Order Anti-TASK1 Potassium Channel Antibody FL650 Conjugate

Related Products

Recently Viewed