Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1) (Two pore K(+) channel KT3.1)
Potassium two pore domain channel subfamily K member 3 is encoded by the gene KCNK3. KCNK3 is a member of the two pore domain potassium channel (TC 1.A.1.8) family. KCNK3 is a pH dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from the potassium ion concentration on either side of the membrane, with it functioning as an outward rectifier when the external potassium concentration is low, and it functioning as an internal rectifier when the external potassium concentration is high. KCNK3 is expressed in the heart, lung, brain, liver, kidney, and skeletal muscle. Diseases associated with KCNK3 include Pulmonary Hypertension Primary 4 and Heritable Pulmonary Arterial Hypertension.
ICC, IHC, WB
Kcnk3 Task Task1
Fusion protein amino acids 251-411 (cytoplasmic C-terminus) of rat Acid-sensitive potassium channel protein TASK or TASK1 (also known as Potassium channel subfamily K member 3, TWIK-related acid-sensitive K(+) channel 1, Two pore potassium channel KT3.1, Cardiac two pore background K(+) channel, KCNK3 and cTBAK-1, accession number O54192); Mouse: 96% identity (156/161 amino acids identical); Human: 76% identity (163/161 amino acids identical); Less than 30% identity with TASK3
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