Anti-TASK1 Potassium Channel Antibody (N374/48)

Name: Anti-TASK1 Potassium Channel Antibody
Brand: NeuroMab
SKU: 75-357
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

2 Citations

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Clone

N374/48

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified

Gene Name

Kcnk3 Task Task1

Molecular Weight

50 kDa

Go to Full Product Details

adult rat Whole brain immunohistochemistry.

Adult rat hippocampus immunohistochemistry.

Immunoblot versus crude membranes from adult rat brain (RBM) and wild-type (WT) and TASK1 KO mouse brains probed with N374/48 (left) and N52A/42 (right) TC supe. Mouse brains courtesy of Doug Bayliss (University of Virginia).

adult rat Whole brain immunohistochemistry.

Volume: 100 µL

Variant

Price:

$308

Quantity:

Bulk Order Anti-TASK1 Potassium Channel Antibody

Product Details

Target

Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1) (Two pore K(+) channel KT3.1)

Target Description

Potassium two pore domain channel subfamily K member 3 is encoded by the gene KCNK3. KCNK3 is a member of the two pore domain potassium channel (TC 1.A.1.8) family. KCNK3 is a pH dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from the potassium ion concentration on either side of the membrane, with it functioning as an outward rectifier when the external potassium concentration is low, and it functioning as an internal rectifier when the external potassium concentration is high. KCNK3 is expressed in the heart, lung, brain, liver, kidney, and skeletal muscle. Diseases associated with KCNK3 include Pulmonary Hypertension Primary 4 and Heritable Pulmonary Arterial Hypertension.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N374/48

Isotype

IgG2b

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnk3 Task Task1

Molecular Weight

50 kDa

Antigen

Fusion protein amino acids 251-411 (cytoplasmic C-terminus) of rat Acid-sensitive potassium channel protein TASK or TASK1 (also known as Potassium channel subfamily K member 3, TWIK-related acid-sensitive K(+) channel 1, Two pore potassium channel KT3.1, Cardiac two pore background K(+) channel, KCNK3 and cTBAK-1, accession number O54192); Mouse: 96% identity (156/161 amino acids identical); Human: 76% identity (163/161 amino acids identical); Less than 30% identity with TASK3

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2315942

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with TASK3

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1) (Two pore K(+) channel KT3.1)

UniProt Details

UniProt (Human): O14649
UniProt (Immunogen Species): O54912

Dadi PK, Luo B, Vierra NC, Jacobson DA. (2015), 'TASK-1 Potassium Channels Limit Pancreatic α-Cell Calcium Influx and Glucagon Secretion..' Mol Endocrinol.. 10.1210/me.2014-1321.
Dadi PK, Vierra NC, Jacobson DA. (2014), 'Pancreatic β-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance..' Endocrinology. 10.1210/en.2013-2051.

Recover password

Create my account

Anti-TASK1 Potassium Channel Antibody (N374/48)

Anti-TASK1 Potassium Channel Antibody
SKU: 75-357

Bulk Order Anti-TASK1 Potassium Channel Antibody

Product Details

Related Products

Recently Viewed

Anti-TASK1 Potassium Channel Antibody (N374/48)

Anti-TASK1 Potassium Channel Antibody SKU: 75-357

Bulk Order Anti-TASK1 Potassium Channel Antibody

Product Details

Anti-TASK1 Potassium Channel Antibody
SKU: 75-357