Anti-GluN3A/NR3A Antibody Biotin Conjugate (N416/40)

Name: Anti-GluN3A/NR3A Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-416-BTN
Price: 543.0 USD
Availability: InStock

Our mouse GluN3A/NR3A biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone N416/40. It detects mouse and rat GluN3A/NR3A and is purified by Protein A chromatography. Works in ELISA, IHC, ICC, WB.

Anti-GluN3A/NR3A Antibody Biotin Conjugate

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Species Reactivity

Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 75-416-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

GluN3A/NR3A

Scientific Background

Glutamate receptor ionotropic, NMDA3A, N-Methyl-D-Aspartate Receptor Subtype 3A or GluN3A is encoded by the gene GRIN3A. GluN3A is a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of channel forming ionotropic glutamate receptor which is permeable to cations including calcium, potassium and sodium. GluN3a is expressed in the CNS especially in development and appears to play a role in delaying synapse maturation. Diseases associated with GRIN3A include Macrodactyly

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N416/40

Isotype

IgG2a

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Grin3a

Molecular Weight

110 kDa

Immunogen

Fusion Protein Amino acids 58-87 or 152-176 (extracellular N-terminus) of mouse GluN3A (accession number A2AIR5) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

6430537F04; Glutamate receptor ionotropic; NMDAR-L; NR3A; mKIAA1973; NMDA 3A; NMDA3A

UniProt ID

A2AIR5
UniProt Summary: Component of a non-conventional N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with low calcium permeability and low voltage-dependent block by Mg(2+). During the development of neural circuits, participates in the synaptic refinement period, restricting spine maturation and growth. Forms glutamatergic receptor complexes with GluN1 and GluN2 subunits which are activated by glycine binding to the GluN1 and GluN3 subunits and L-glutamate binding to GluN2 subunits. Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits. GluN3A subunit also binds D-serine. Each GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. By competing with GIT1 interaction with ARHGEF7/beta-PIX, may reduce GIT1/ARHGEF7-regulated local activation of RAC1, hence affecting signaling and limiting the maturation and growth of inactive synapses.

NCBI Gene ID

242443

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Anti-GluN3A/NR3A Antibody Biotin Conjugate (N416/40)

SKU: 75-416-BTN

Product Details

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