Immunofluorescence staining of unpermerabilized COS cells transiently transfected with GFP- tagged GluN3A/NR3a and GluN1/NR1 plasmids with N416/40 (red). Images courtesy of Sonia Marco Martinez and Isabel Perez- Otano (University of Navarra).
Glutamate receptor ionotropic, NMDA3A
Glutamate receptor ionotropic, NMDA3A, N-Methyl-D-Aspartate Receptor Subtype 3A or GluN3A is encoded by the gene GRIN3A. GluN3A is a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of channel forming ionotropic glutamate receptor which is permeable to cations including calcium, potassium and sodium. GluN3a is expressed in the CNS especially in development and appears to play a role in delaying synapse maturation. Diseases associated with GRIN3A include Macrodactyly
ICC, IHC, WB
Fusion protein amino acids 58-87 or 152-176 (extracellular N-terminus) of mouse GluN3A (also known as Ionotropic glutamate receptor 3A, N-methyl-D-aspartate receptor subtype 3A, Glutamate receptor chi-1, NMDAR3A, NMDAR-L, NMDAR-L1, NR3A, Grin3A and KIAA1973, accession number A2AIR5); Rat: 93% or 100% identity (28/30 or 25/25 amino acids identical); Human: 83% or 96% identity (25/30 or 24/25 amino acids identical); 100% identity with Short isoform; 50% identity with GluN3B/NR3B and other GluN/NMDA receptors
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