Anti-GABA-A-R-Alpha4 Antibody FL490 Conjugate (N398A/34)

Name: Anti-GABA-A-R-Alpha4 Antibody FL490 Conjugate
Brand: NeuroMab
SKU: 75-383-FL490
Price: 499.0 USD
Availability: InStock

from NeuroMab

Available Conjugates

Unconjugated

550

594

650

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Clone

N398A/34

Applications

ICC, IHC

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

Gabra4

Molecular Weight

60 kDa

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Volume: 200 µL

Variant

Price:

$499

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Bulk Order Anti-GABA-A-R-Alpha4 Antibody FL490 Conjugate

Product Details

Target

GABA-A-R-Alpha4

Target Description

Gamma-aminobutyric acid receptor subunit alpha-4 or GABA AR alpha4 is encoded by the gene GABRA4. GABAA receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR alpha 4 is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR alpha 4 has been found to be expressed in skeletal muscle tissue, adult mammalian kidney, heart and primarily in brain at the cell junction, synapse,and the postsynaptic cell membrane. Disorders involving the GABRA4 gene include autism, Status Epilepticus and restless legs syndrome.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N398A/34

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Gabra4

Molecular Weight

60 kDa

Antigen

Fusion protein amino acids 410-450 (cytoplasmic C-terminus) of rat GABA-A-R-Alpha4 (accession number P28471) produced recombinantly in E. Coli

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2940268

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

Does not cross-react with other GABA-A receptor Alpha subunits

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Gamma-aminobutyric acid receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4)

UniProt Details

UniProt (Human): P48169
UniProt (Immunogen Species): P28471

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Anti-GABA-A-R-Alpha4 Antibody FL490 Conjugate (N398A/34)

Available Conjugates

Anti-GABA-A-R-Alpha4 Antibody FL490 Conjugate
SKU: 75-383-FL490

Bulk Order Anti-GABA-A-R-Alpha4 Antibody FL490 Conjugate

Product Details

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Anti-GABA-A-R-Alpha4 Antibody FL490 Conjugate (N398A/34)

Available Conjugates

Anti-GABA-A-R-Alpha4 Antibody FL490 Conjugate SKU: 75-383-FL490

Bulk Order Anti-GABA-A-R-Alpha4 Antibody FL490 Conjugate

Product Details

Anti-GABA-A-R-Alpha4 Antibody FL490 Conjugate
SKU: 75-383-FL490