Anti-Kv3.1B K+ Channel Antibody Biotin Conjugate (N16B/8)

Name: Anti-Kv3.1B K+ Channel Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-041-BTN
Price: 543.0 USD
Availability: InStock

Our mouse Kv3.1b K+ channel biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone N16B/8. It detects hamster, human, non-human primate, mouse, and rat Kv3.1b K+ channel and is purified by Protein A chromatography. Works in ELISA, IHC, ICC, WB, IP.

Anti-Kv3.1B K+ Channel Antibody Biotin Conjugate

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Species Reactivity

Hamster, Human, Mouse, Non-Human Primate, Rat

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 75-041-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Kv3.1b K+ channel

Scientific Background

Potassium voltage-gated channel subfamily C member 1, or Kv3.1b is encoded by the gene KCNC1. Kv3.1 is a member of the Shaw subfamily of voltage gated potassium channels. Kv3.1b is expressed in many parts of the brain including the cerebellum, globus pallidus, subthalamic nucleus, substantia nigra, cortical and hippocampal in neurons at presynaptic membranes. It is also expressed in retinal ganglion cells and muscle and testis tissues. It is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Its function is important in repolarization of action potentials and is expressed in neurons that execute repetitive high frequency firing. Alterations in expression are associated with certain types of epilepsy, spinocerebellar ataxia, unverricht-lundborg syndrome and demyelinating diseases.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N16B/8

Isotype

IgG1

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

Kcnc1

Molecular Weight

110 kDa

Immunogen

Fusion Protein Amino acids 437-585 (cytoplasmic C-terminus) of rat Kv3.1b (accession number P25122) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Hamster, Human, Mouse, Non-Human Primate, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Potassium voltage-gated channel subfamily C member 1 (NGK2) (RAW2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4)

UniProt ID

P25122

Shipping

Shipped on ice packs

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Anti-Kv3.1B K+ Channel Antibody Biotin Conjugate (N16B/8)

SKU: 75-041-BTN

Product Details

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