Anti-Kv3.1B K+ Channel Antibody FL550 Conjugate (N16B/8)

Name: Anti-Kv3.1B K+ Channel Antibody FL550 Conjugate
Brand: NeuroMab
SKU: 75-041-FL550
Price: 515.0 USD
Availability: InStock

Our Anti-Kv3.1b K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N16B/8. It detects hamster, human, non-human primate, mouse, and rat Kv3.1b K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Hamster, Human, Mouse, Non-Human Primate, Rat

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

Unconjugated

490

594

650

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Data Sheet

SKU: 75-041-FL550

Volume: 200 µL

Variant

Price:

$515.00

Quantity:

Product Details

Target

Kv3.1b K+ channel

Target Description

Potassium voltage-gated channel subfamily C member 1, or Kv3.1b is encoded by the gene KCNC1. Kv3.1 is a member of the Shaw subfamily of voltage gated potassium channels. Kv3.1b is expressed in many parts of the brain including the cerebellum, globus pallidus, subthalamic nucleus, substantia nigra, cortical and hippocampal in neurons at presynaptic membranes. It is also expressed in retinal ganglion cells and muscle and testis tissues. It is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Its function is important in repolarization of action potentials and is expressed in neurons that execute repetitive high frequency firing. Alterations in expression are associated with certain types of epilepsy, spinocerebellar ataxia, unverricht-lundborg syndrome and demyelinating diseases.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N16B/8

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Kcnc1

Molecular Weight

110 kDa

Antigen

Fusion protein amino acids 437-585 (cytoplasmic C-terminus) of rat Kv3.1b (accession number P25122) produced recombinantly in E. Coli

Species Reactivity

Hamster, Human, Mouse, Non-Human Primate, Rat

Antibody Registry ID

AB_2939197

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL550 Ex: 550 nm, Em: 575 nm

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Potassium voltage-gated channel subfamily C member 1 (NGK2) (RAW2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4)

UniProt Details

UniProt (Human): P48547
UniProt (Immunogen Species): P25122

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Anti-Kv3.1B K+ Channel Antibody FL550 Conjugate (N16B/8)

SKU: 75-041-FL550

Product Details

Bulk Order Anti-Kv3.1B K+ Channel Antibody FL550 Conjugate

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