Anti-Kv3.1B K+ Channel Antibody FL490 Conjugate (N16B/8)

Name: Anti-Kv3.1B K+ Channel Antibody FL490 Conjugate
Brand: NeuroMab
SKU: 75-041-FL490
Price: 499.0 USD
Availability: InStock

from NeuroMab

Available Conjugates

Unconjugated

550

594

650

Product Type

Primary Antibody

Species Reactivity

Hamster, Human, Mouse, Non-Human Primate, Rat

Clone

N16B/8

Applications

ICC, IHC

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

Kcnc1

Molecular Weight

110 kDa

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Volume: 200 µL

Variant

Price:

$499

Quantity:

Bulk Order Anti-Kv3.1B K+ Channel Antibody FL490 Conjugate

Product Details

Target

Kv3.1b K+ channel

Target Description

Potassium voltage-gated channel subfamily C member 1, or Kv3.1b is encoded by the gene KCNC1. Kv3.1 is a member of the Shaw subfamily of voltage gated potassium channels. Kv3.1b is expressed in many parts of the brain including the cerebellum, globus pallidus, subthalamic nucleus, substantia nigra, cortical and hippocampal in neurons at presynaptic membranes. It is also expressed in retinal ganglion cells and muscle and testis tissues. It is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Its function is important in repolarization of action potentials and is expressed in neurons that execute repetitive high frequency firing. Alterations in expression are associated with certain types of epilepsy, spinocerebellar ataxia, unverricht-lundborg syndrome and demyelinating diseases.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N16B/8

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Kcnc1

Molecular Weight

110 kDa

Antigen

Fusion protein amino acids 437-585 (cytoplasmic C-terminus) of rat Kv3.1b (accession number P25122) produced recombinantly in E. Coli

Species Reactivity

Hamster, Human, Mouse, Non-Human Primate, Rat

Antibody Registry ID

AB_2939196

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Potassium voltage-gated channel subfamily C member 1 (NGK2) (RAW2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4)

UniProt Details

UniProt (Human): P48547
UniProt (Immunogen Species): P25122

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Anti-Kv3.1B K+ Channel Antibody FL490 Conjugate (N16B/8)

Available Conjugates

Anti-Kv3.1B K+ Channel Antibody FL490 Conjugate
SKU: 75-041-FL490

Bulk Order Anti-Kv3.1B K+ Channel Antibody FL490 Conjugate

Product Details

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Anti-Kv3.1B K+ Channel Antibody FL490 Conjugate (N16B/8)

Available Conjugates

Anti-Kv3.1B K+ Channel Antibody FL490 Conjugate SKU: 75-041-FL490

Bulk Order Anti-Kv3.1B K+ Channel Antibody FL490 Conjugate

Product Details

Anti-Kv3.1B K+ Channel Antibody FL490 Conjugate
SKU: 75-041-FL490