Anti-Kv3.1B K+ Channel Antibody (N16B/8)
Primary Antibody
Hamster, Human, Mouse, Non-Human Primate, Rat
N16B/8
ICC, IHC, IP, WB
Mouse
Purified
Kcnc1
110 kDa
![Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].](http://cdn.shopify.com/s/files/1/0014/8806/0475/products/validation-image-73-041-n16b-8-wb-3_{width}x.jpg?v=1626903923)
Adult rat hippocampus immunohistochemistry.
![Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].](http://cdn.shopify.com/s/files/1/0014/8806/0475/products/validation-image-73-041-n16b-8-wb-3_1024x.jpg?v=1626903923)
Product Specific References for Applications and Species
- Immunocytochemistry: Human | Mouse | Non-Human Primate | Rat
- Immunohistochemistry: Human | Mouse | Non-Human Primate | Rat
- Immunoprecipitation: Mouse
- Western Blot: Hamster | Human | Mouse | Non-Human Primate | Rat
- Additional Publications: Unspecified
| Immunocytochemistry: Human | ||
| PMID | Dilution | Publication |
| 34232791 | not listed | Zhang, Y., et al. 2021. A KCNC1 mutation in epilepsy of infancy with focal migrating seizures produces functional channels that fail to be regulated by PKC phosphorylation. Journal of Neurophysiology, 532-9. |
| 24291260 | not listed | Bae, S.H., et al. 2014. Src regulates membrane trafficking of the Kv3.1b channel.. FEBS Letters, 86-91. |
| Immunocytochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 23233530 | 1:200 | Cotella, D., et al. 2013. An evolutionarily conserved mode of modulation of Shaw-like K⁺ channels.. The FASEB Journal, 1381-93. |
| 21106837 | not listed | Xu, M., et al. 2010. Kinesin I transports tetramerized Kv3 channels through the axon initial segment via direct binding. . Journal of Neuroscience, 15987-16001. |
| Immunocytochemistry: Non-Human Primate | ||
| PMID | Dilution | Publication |
| 24291260 | not listed | Bae, S.H., et al. 2014. Src regulates membrane trafficking of the Kv3.1b channel.. FEBS Letters, 86-91. |
| Immunocytochemistry: Rat | ||
| PMID | Dilution | Publication |
| 33154197 | 1:500 | Kim, W.B., et al. 2020. Distribution of K v 3 Subunits in Cochlear Afferent and Efferent Nerve Fibers Implies Distinct Role in Auditory Processing. Experimental Neurobiology, 344-55. |
| 28322444 | not listed | Vicente, P.C., et al. 2018. Identification and characterization of site-specific N-glycosylation in the potassium channel Kv3.1b. Journal of Cellular Physiology, 549-58. |
| 23487040 | not listed | Barry, J., et al. 2013. Activation of conventional kinesin motors in clusters by Shaw voltage-gated K+ channels.. Journal of Cell Science, 2027-41. |
| Immunohistochemistry: Human | ||
| PMID | Dilution | Publication |
| 24838064 | 1:500 | Beebe, K., et al. 2014. Distribution of fragile X mental retardation protein in the human auditory brainstem.. Neuroscience, 79-91. |
| Immunohistochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 34180393 | 1:500 | Stevens, S.R., et al. 2021. Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3. 1b K+ channels. . Elife, e66491. |
| 32246836 | 1:500 | Choudhury, N., et al. 2020. Kv3.1 and Kv3.3 subunits differentially contribute to Kv3 channels and action potential repolarization in principal neurons of the auditory brainstem. The Journal of Physiology, 2199-2222. |
| 31676823 | 1:400 | Malik, R., et al. 2019. Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons. Nature Communications, 4994. |
| 28712654 | 1:1000 | Favuzzi, E., et al. 2017. Activity-dependent gating of parvalbumin interneuron function by the perineuronal net protein brevican. . Neuron, 639-655. |
| 27264355 | not listed | Iijima, Y., et al. 2016. Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure. Scientific Reports, 27400. |
| 26269632 | not listed | Smith, K.E., et al. 2015. Phosphoinositide Modulation of Heteromeric Kv1 Channels Adjusts Output of Spiral Ganglion Neurons from Hearing Mice.. Journal of Neuroscience, 11221-11232. |
| 26223835 | 1:300 | Blosa, M., et al. 2015. The extracellular matrix molecule brevican is an integral component of the machinery mediating fast synaptic transmission at the calyx of Held.. The Journal of Physiology, 4341-4360. |
| 24048834 | 1:500 | Jalabi, W., et al. 2013. Sound localization ability and glycinergic innervation of the superior olivary complex persist after genetic deletion of the medial nucleus of the trapezoid body.. Journal of Neuroscience, 15044-9. |
| 23699522 | 1:1000 | Tong, H., et al. 2013. Protection from noise-induced hearing loss by Kv2.2 potassium currents in the central medial olivocochlear system.. Journal of Neuroscience, 9113-21. |
| 21676499 | not listed | Wykes, R., et al. 2012. Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice.. Neurobiology of Aging, 1609-23. |
| 21791288 | 1:1000 | Steinert, J.R., et al. 2011. Nitric oxide is an activity-dependent regulator of target neuron intrinsic excitability.. Neuron, 291-305. |
| 20592126 | 1:100 | Gittis, A.H., et al. 2010. Mechanisms of sustained high firing rates in two classes of vestibular nucleus neurons: differential contributions of resurgent Na, Kv3, and BK currents.. Journal of Neurophysiology, 1625-34. |
| 20016089 | 1:50 | Hurlock, E.C., et al. 2009. Rescue of motor coordination by Purkinje cell-targeted restoration of Kv3.3 channels in Kcnc3-null mice requires Kcnc1.. Journal of Neuroscience, 15735-44. |
| 19359372 | 1:1000 | Hardman, R.M., et al. 2009. Ether-à-go-go-related gene K+ channels contribute to threshold excitability of mouse auditory brainstem neurons.. The Journal of Physiology, 2487-97. |
| Immunohistochemistry: Non-Human Primate | ||
| PMID | Dilution | Publication |
| 29668858 | not listed | Kelly, J.G., et al. 2019. Densities and Laminar Distributions of Kv3.1b-, PV-, GABA-, and SMI-32-Immunoreactive Neurons in Macaque Area V1. Cerebral Cortex, 1921-37. |
| 28213922 | not listed | Soares, D., et al. 2017. Expression of Kv3.1b potassium channel is widespread in macaque motor cortex pyramidal cells: A histological comparison between rat and macaque. The Journal of Comparative Neurology, 2164-2174. |
| Immunohistochemistry: Rat | ||
| PMID | Dilution | Publication |
| 31936259 | 1:100 | Poveda, C.M., et al. 2020. Expression and Localization of Kv1.1 and Kv3.1b Potassium Channels in the Cochlear Nucleus and Inferior Colliculus after Long-Term Auditory Deafferentation. Brain Sciences, 35. |
| 28213922 | not listed | Soares, D., et al. 2017. Expression of Kv3.1b potassium channel is widespread in macaque motor cortex pyramidal cells: A histological comparison between rat and macaque. The Journal of Comparative Neurology, 2164-2174. |
| 24723263 | 1:100 | Dufour, M.A., et al. 2014. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development.. Journal of Neuroscience Research, 981-99. |
| 22105078 | not listed | Gu, Y., et al. 2012. Alternative splicing regulates kv3.1 polarized targeting to adjust maximal spiking frequency.. The Journal of Biological Chemistry, 1755-69. |
| 20211981 | 1:1000 | Tong, H., et al. 2010. Regulation of Kv channel expression and neuronal excitability in rat medial nucleus of the trapezoid body maintained in organotypic culture.. The Journal of Physiology, 1451-68. |
| 20083165 | 1:1000 | Henderson, Z., et al. 2010. Distribution and role of Kv3.1b in neurons in the medial septum diagonal band complex.. Neuroscience, 952-69. |
| 20008465 | 1:1000 | Steinert, J.R., et al. 2010. NMDAR-mediated EPSCs are maintained and accelerate in time course during maturation of mouse and rat auditory brainstem in vitro.. The Journal of Physiology, 447-63. |
| Immunoprecipitation: Mouse | ||
| PMID | Dilution | Publication |
| 34180393 | 5ul | Stevens, S.R., et al. 2021. Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3. 1b K+ channels. . Elife, e66491. |
| Western Blot: Hamster | ||
| PMID | Dilution | Publication |
| 24040379 | not listed | Hall, M.K., et al. 2013. Glycan structures contain information for the spatial arrangement of glycoproteins in the plasma membrane.. PLoS One, e75013. |
| Western Blot: Human | ||
| PMID | Dilution | Publication |
| 34232791 | not listed | Zhang, Y., et al. 2021. A KCNC1 mutation in epilepsy of infancy with focal migrating seizures produces functional channels that fail to be regulated by PKC phosphorylation. Journal of Neurophysiology, 532-9. |
| 32260356 | not listed | Hall, M.K., et al. 2020. Knockdown of N-Acetylglucosaminyltransferase-II Reduces Matrix Metalloproteinase 2 Activity and Suppresses Tumorigenicity in Neuroblastoma Cell Line. Biology, 71. |
| 24291260 | not listed | Bae, S.H., et al. 2014. Src regulates membrane trafficking of the Kv3.1b channel.. FEBS Letters, 86-91. |
| 23734863 | not listed | Zhao, J., et al. 2013. Spinocerebellar ataxia-13 Kv3.3 potassium channels: arginine-to-histidine mutations affect both functional and protein expression on the cell surface.. Biochemical Journal, 259-65. |
| Western Blot: Mouse | ||
| PMID | Dilution | Publication |
| 34180393 | 1:1000 | Stevens, S.R., et al. 2021. Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3. 1b K+ channels. . Elife, e66491. |
| 32246836 | 1:1000 | Choudhury, N., et al. 2020. Kv3.1 and Kv3.3 subunits differentially contribute to Kv3 channels and action potential repolarization in principal neurons of the auditory brainstem. The Journal of Physiology, 2199-2222. |
| 26223835 | 1:300 | Blosa, M., et al. 2015. The extracellular matrix molecule brevican is an integral component of the machinery mediating fast synaptic transmission at the calyx of Held.. The Journal of Physiology, 4341-4360. |
| 24259518 | 1:2000 | Dagley, L.F., et al. 2014. Quantitative proteomic profiling reveals novel region-specific markers in the adult mouse brain.. Proteomics, 241-261. |
| 21900579 | not listed | Shakkottai, V.G., et al. 2011. Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3.. Journal of Neuroscience, 13002-14. |
| 20685971 | not listed | Strumbos, J.G., et al. 2010. Fragile X mental retardation protein is required for rapid experience-dependent regulation of the potassium channel Kv3.1b.. Journal of Neuroscience, 10263-71. |
| Western Blot: Non-Human Primate | ||
| PMID | Dilution | Publication |
| 24291260 | not listed | Bae, S.H., et al. 2014. Src regulates membrane trafficking of the Kv3.1b channel.. FEBS Letters, 86-91. |
| Western Blot: Rat | ||
| PMID | Dilution | Publication |
| 32260356 | not listed | Hall, M.K., et al. 2020. Knockdown of N-Acetylglucosaminyltransferase-II Reduces Matrix Metalloproteinase 2 Activity and Suppresses Tumorigenicity in Neuroblastoma Cell Line. Biology, 71. |
| 31936259 | 1:200 | Poveda, C.M., et al. 2020. Expression and Localization of Kv1.1 and Kv3.1b Potassium Channels in the Cochlear Nucleus and Inferior Colliculus after Long-Term Auditory Deafferentation. Brain Sciences, 35. |
| 29902282 | not listed | Hall, M.K., et al. 2018. Lack of complex type N-glycans lessens aberrant neuronal properties. PLoS One, e0199202. |
| 28322444 | not listed | Vicente, P.C., et al. 2018. Identification and characterization of site-specific N-glycosylation in the potassium channel Kv3.1b. Journal of Cellular Physiology, 549-58. |
| 21541302 | not listed | Hall, M.K., et al. 2011. Importance of glycosylation on function of a potassium channel in neuroblastoma cells.. PLoS One, e19317. |
| 21110920 | not listed | Song, M.Y., et al. 2010. Contribution of the delayed-rectifier potassium channel Kv2.1 to acute spinal cord injury in rats.. BMB Reports, 756-60. |
| Additional Publications: Unspecified | ||
| PMID | Publication | |
| 18364742 | Schwalbe, R.A., et al. 2008. Novel Kv3 glycoforms differentially expressed in adult mammalian brain contain sialylated N-glycans.. Biochemistry and Cell Biology, 21-30. | |