Anti-Kv3.1B K+ Channel Antibody (N16B/8)

Name: Anti-Kv3.1B K+ Channel Antibody
Brand: NeuroMab
SKU: 75-041
Price: 345.0 USD
Availability: InStock

from NeuroMab Datasheet

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Clonality

Monoclonal

Applications

IHC, WB

Host Species

Mouse

Gene Name

Kcnc1

Molecular Weight

110 kDa

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Adult rat hippocampus immunohistochemistry.

Immunoblot versus adult rat brain membranes (RBM), and adult mouse hippocampal membranes (MBM) from Kv3.1/Kv3.3 double knockout and WT mice (mouse samples courtesy of Dr. Rolf Joho).

Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].

Adult rat hippocampus immunohistochemistry.

Product Details

Target

Kv3.1b K+ channel

Target Description

Potassium voltage-gated channel subfamily C member 1, or Kv3.1b is encoded by the gene KCNC1. Kv3.1 is a member of the Shaw subfamily of voltage gated potassium channels. Kv3.1b is expressed in many parts of the brain including the cerebellum, globus pallidus, subthalamic nucleus, substantia nigra, cortical and hippocampal in neurons at presynaptic membranes. It is also expressed in retinal ganglion cells and muscle and testis tissues. It is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Its function is important in repolarization of action potentials and is expressed in neurons that execute repetitive high frequency firing. Alterations in expression are associated with certain types of epilepsy, spinocerebellar ataxia, unverricht-lundborg syndrome and demyelinating diseases.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N16B/8

Isotype

IgG1

Applications

IHC, WB

Host Species

Mouse

Gene Name

Kcnc1

Molecular Weight

110 kDa

Antigen

Fusion protein amino acids 437-585 (cytoplasmic C-terminus) of rat Kv3.1b (accession number P25122); Mouse: 100% identity (149/149 amino acids identical); Human: 100% identity (84/84 amino acids identical, partial sequence)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2131480

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Potassium voltage-gated channel subfamily C member 1 (NGK2) (RAW2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4)

UniProt Details

UniProt (Human): P48547
UniProt (Immunogen Species): P25122

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Anti-Kv3.1B K+ Channel Antibody (N16B/8)

Anti-Kv3.1B K+ Channel Antibody
SKU: 75-041

Product Details

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Anti-Kv3.1B K+ Channel Antibody (N16B/8)

Anti-Kv3.1B K+ Channel Antibody SKU: 75-041

Product Details

Anti-Kv3.1B K+ Channel Antibody
SKU: 75-041