Transient receptor potential cation channel subfamily M member 6 or TrpM6 is encoded by the gene TRPM6. TrpM6 is a member of the transient receptor potential ion channel family and acts as a serine/threonine-protein kinase. TrpM6 has an essential function in magnesium transport and is involved with magnesium absorption in the gut and kidney. TRPM6 is primarily expressed in the kidney, colon, GI tract and placenta kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia.
Fusion protein amino acids 1258-1480 (cytoplasmic C-terminus) of human TrpM6 (also known as Transient receptor potential cation channel subfamily M member 6, Melastatin-related TRP cation channel 6, Channel kinase 2 and CHAK2, accession number Q9BX84)
TrpM6 (Transient receptor potential cation channel subfamily M member 6) (Melastatin-related TRP cation channel 6) (Channel kinase 2)
TC Supernatant: AB_2631244
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.