Human Mouse Rat
Fusion protein amino acids 1315-1607 (cytoplasmic C-terminus) of human LAR (also known as Leukocyte antigen related, Leukocyte common antigen-related phosphatase, Receptor-type tyrosine-protein phosphatase F and PTPRF, accession number P10586)
Rat: 97% identity (286/293 amino acids identical)
Mouse: 97% identity (285/293 amino acids identical)
>80% identity with PTPRD and PTPRS
>50% identity with PTPRM and PTPRK
Cross-reacts with PTPRD or PTPRS
Receptor-type tyrosine-protein phosphatase F (EC 22.214.171.124) (Leukocyte common antigen related) (LAR) Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 126.96.36.199) Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 188.8.131.52) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma)
PTPRF LAR PTPRD PTPRS
TC Supernatant: AB_10675298
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecularweight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
85 kDa(full-length is 210 kDa, smaller due to proteolysis into P-subunit containing transmembrane and intracellular domains)
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
Citations and References
- Kuhn PH, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers U, Imhof A, Hoffmeister A, Haass C, Roßner S, Bräse S, Lichtenthaler SF.. (2012), 'Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons. .' The EMBO Journal. 10.1038/emboj.2012.173. "