Anti-Neuregulin-CRD (Cysteine-Rich Domain, Type III) Antibody (N126B/31)

Name: Anti-Neuregulin-CRD (Cysteine-Rich Domain, Type III) Antibody
Brand: NeuroMab
SKU: 75-226
Price: 319.0 USD
Availability: InStock

3 Citations

Our Anti-Neuregulin-CRD (Cysteine-rich domain, Type III) mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N126B/31. It detects human and rat Neuregulin-CRD (Cysteine-rich domain, Type III), and is purified by Protein A chromatography. It is great for use in ICC, WB.

Tissue and transfected cell immunoblot: extracts of rat brain membrane (RBM) and COS cells transiently transfected with Myc-tagged Neuregulin-CRD (NRG-CRD) or untagged Kv2.1 plasmid and probed with N126B/31 (left), 19E10 (middle) and K89/41 (right) TC supe.

Species Reactivity

Human, Rat

Applications

ICC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-226

Volume: 100 µL

Variant

Price:

$319

Quantity:

Product Details

Target

Neuregulin-CRD (Cysteine-rich domain, Type III)

Target Description

Neuregulin 1 is encoded by the gene NRG1. NRG1 is a member of the neuregulin family. NRG1 is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. NRG1 is expressed in the nervous system, intestine, muscle, and heart. Diseases associated with NRG1 include Schizphrenia 6 and Lung Cancer.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N126B/31

Isotype

IgG2b

Applications

ICC, WB

Host Species

Mouse

Gene Name

NRG1

Molecular Weight

30 kDa

Antigen

Fusion protein amino acids 1-75 (membrane-associated N-terminus) of human Neuregulin-1 (accession number Q96IB3) produced recombinantly in E. Coli

Species Reactivity

Human, Rat

Antibody Registry ID

AB_10672367

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Neuregulin 1

UniProt Details

UniProt (Human): Q02297
UniProt (Immunogen Species): Q96IB3

Venkatesan K, Liu Y, Goldfarb M. (2014), 'Fast-onset long-term open-state block of sodium channels by A-type FHFs mediates classical spike accommodation in hippocampal pyramidal neurons..' Journal of Neuroscience. 10.1523/JNEUROSCI.1271-14.2014.
Song F, Chiang P, Ravits J, Loeb JA. (2014), 'Activation of microglial neuregulin1 signaling in the corticospinal tracts of ALS patients with upper motor neuron signs..' Amyotroph Lateral Scler Frontotemporal Degener.. 10.3109/21678421.2013.853802.
Zhang K, Wong P, Zhang L, Jacobs B, Borden EC, Aster JC, Bedogni B. (2012), 'A Notch1-neuregulin1 autocrine signaling loop contributes to melanoma growth..' Oncogene. 10.1038/onc.2011.606.

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Anti-Neuregulin-CRD (Cysteine-Rich Domain, Type III) Antibody (N126B/31)

SKU: 75-226

Product Details

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