Fusion protein amino acids 1-75 (membrane-associated N-terminus) of human Neuregulin-1 (also known as NRG1, Neu differentiation factor, NDF, Heregulin, HRG, HGL, Breast cancer cell differentiation factor p45, Acetylcholine receptor-inducing activity, ARIA, Glial growth factor, GGF, Sensory and motor-neuron-derived factor or SMDF, accession number Q96IB3)
Mouse: 85% identity (64/75 amino acids identical)
Rat: 82% identity (63/76 amino acids identical)
TC Supernatant: AB_10672412
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.
Citations and References
- Venkatesan K, Liu Y, Goldfarb M.. (2014), 'Fast-onset long-term open-state block of sodium channels by A-type FHFs mediates classical spike accommodation in hippocampal pyramidal neurons. .' Journal of Neuroscience. 10.1523/JNEUROSCI.1271-14.2014. " "
- Song F, Chiang P, Ravits J, Loeb JA.. (2014), 'Activation of microglial neuregulin1 signaling in the corticospinal tracts of ALS patients with upper motor neuron signs. .' Amyotroph Lateral Scler Frontotemporal Degener.. 10.3109/21678421.2013.853802. " "
- Zhang K, Wong P, Zhang L, Jacobs B, Borden EC, Aster JC, Bedogni B.. (2012), 'A Notch1-neuregulin1 autocrine signaling loop contributes to melanoma growth. .' Oncogene. 10.1038/onc.2011.606. "