Anti-Neuregulin-CRD (Cysteine-Rich Domain, Type III) Antibody FL490 Conjugate (N126B/31)

Name: Anti-Neuregulin-CRD (Cysteine-Rich Domain, Type III) Antibody FL490 Conjugate
Brand: NeuroMab
SKU: 75-226-FL490
Price: 486.0 USD
Availability: InStock

Our mouse Neuregulin-CRD (Cysteine-rich domain, Type III) FL490 conjugate monoclonal antibody from NeuroMab is produced in-house from clone N126B/31. It detects human and rat Neuregulin-CRD (Cysteine-rich domain, Type III) and is purified by Protein A chromatography. Works in ICC.

Anti-Neuregulin-CRD (Cysteine-Rich Domain, Type III) Antibody FL490 Conjugate

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Species Reactivity

Human, Rat

Applications

ICC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-226-FL490

Volume: 200 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Neuregulin-CRD (Cysteine-rich domain, Type III)

Scientific Background

Neuregulin 1 is encoded by the gene NRG1. NRG1 is a member of the neuregulin family. NRG1 is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. NRG1 is expressed in the nervous system, intestine, muscle, and heart. Diseases associated with NRG1 include Schizphrenia 6 and Lung Cancer.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N126B/31

Isotype

IgG2b

Applications

ICC

Host Species

Mouse

Gene Name

NRG1

Molecular Weight

30 kDa

Immunogen

Fusion protein amino acids 1-75 (membrane-associated N-terminus) of human Neuregulin-1 (accession number Q96IB3) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human, Rat

Antibody Registry ID

AB_2939824

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

ARIA; Neuregulin 1; GGF2; HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; NRG1-IT2; SMDF; pro-neuregulin-1; membrane-bound isoform; acetylcholine receptor-inducing activity; glial growth factor 2; heregulin; alpha (45kD; ERBB2 p185-activator; neu differentiation factor; pro-NRG1; sensory and motor neuron derived factor

UniProt ID

Q96IB3
UniProt Summary: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4. Binds to ERBB3. Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1. Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons.

NCBI Gene ID

3084

Shipping

Shipped on ice packs

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Anti-Neuregulin-CRD (Cysteine-Rich Domain, Type III) Antibody FL490 Conjugate (N126B/31)

SKU: 75-226-FL490

Product Details

Bulk Order Anti-Neuregulin-CRD (Cysteine-Rich Domain, Type III) Antibody FL490 Conjugate

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