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Products: Primary Antibodies

Anti-Nav1.6 Na+ channel Antibody (K87A/10)

NeuroMab Logo from NeuroMab

 Datasheet

PRODUCT OPTIONS

Brand Catalog # Option Volume Concentration Price
Brand
NeuroMab Logo
Catalog #
75-026
Option
Purified
Volume
100 µL
Concentration
1 mg/mL
Price
$325.00
Brand
NeuroMab Logo
Catalog #
73-026
Option
TC Supernatant
Volume
5 mL
Concentration
Lot dependent
Price
$275.00

Validation Images


Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Antibody Isotype:

IgG1

Species Reactivity:

Human Mouse Rat

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

IHC IP

Target Description:

Nav1.6 Na+ channel (sodium channel, voltage-gated, type 8, alpha subunit/ SCN8A) is a member of voltage-gated sodium ion channel subunit family. It is encoded by gene Scn8a in human.The channel switches between open and close conformation in response to the voltage difference accross the membrane. Nav1.6 Na+ channel is located at the nodes of Ranvier. It heavily participates in the regulation of nerve conduction velocity. It has been shown that Nav1.6 Na+ channel loss in roddents induces paralysis due to the failure of the neuromuscular junction (Wagnon et al., 2016).

Immunogen:

Synthetic peptide 459-476 (intracellular interdomain loop I-II) of rat Nav1.6 (accession number O88420); Human: 88% identity (16/18 amino acids identical); Mouse: 100% identity (18/18 amino acids identical)

Cross Reactivity:

No cross-reactivity reported

Protein Name(s):

Nav1.6 Na+ channel

Gene Name(s):

Scn8a

Antibody Registry ID:

Purified: AB_2184197
TC Supernatant: AB_10673284


Antibody Validation and Application Notes


This antibody has been validated using the following assays:
Knockout Validation:

This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).

Western Blot:

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Immunocytochemistry:

This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.

Immunohistochemistry:
This antibody shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.

Molecular Weight:

K87A/10 does not work for immunoblotting


Quality Control


The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.