Anti-Nav1.6 Na+ Channel Antibody FL490 Conjugate (K87A/10)

Name: Anti-Nav1.6 Na+ Channel Antibody FL490 Conjugate
Brand: NeuroMab
SKU: 75-026-FL490
Price: 531.0 USD
Availability: InStock

Our Anti-Nav1.6 Na+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K87A/10. It is KO validated, detects human, mouse, and rat Nav1.6 Na+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

550

594

650

Carrier-Free

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Data Sheet

KO Validated

SKU: 75-026-FL490

Volume: 200 µL

Variant

Price:

$531.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Nav1.6 Na+ channel

Target Description

Nav1.6 Na+ channel (sodium channel, voltage-gated, type 8, alpha subunit/ SCN8A) is a member of voltage-gated sodium ion channel subunit family. It is encoded by gene Scn8a in human.The channel switches between open and close conformation in response to the voltage difference accross the membrane. Nav1.6 Na+ channel is located at the nodes of Ranvier. It heavily participates in the regulation of nerve conduction velocity. It has been shown that Nav1.6 Na+ channel loss in roddents induces paralysis due to the failure of the neuromuscular junction (Wagnon et al., 2016).

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

K87A/10

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Scn8a

Molecular Weight

<200 kDa

Antigen

Synthetic peptide 459-476 (intracellular interdomain loop I-II) of rat Nav1.6 (accession number O88420)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2939160

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Sodium channel protein type 8 subunit alpha (Peripheral nerve protein type 4) (PN4) (Sodium channel 6) (NaCh6) (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6)

UniProt ID

O88420

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Anti-Nav1.6 Na+ Channel Antibody FL490 Conjugate (K87A/10)

SKU: 75-026-FL490

Product Details

Bulk Order Anti-Nav1.6 Na+ Channel Antibody FL490 Conjugate

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