Anti-Nav1.6 Na+ Channel Antibody (BSA and Azide free) (K87A/10)

Name: Anti-Nav1.6 Na+ Channel Antibody (BSA and Azide free)
Brand: NeuroMab
SKU: 75-026-CF
Price: 486.0 USD
Availability: InStock

Our mouse Nav1.6 Na+ channel carrier-free monoclonal antibody from NeuroMab is produced in-house from clone K87A/10. It detects feline, human, mouse, and rat Nav1.6 Na+ channel and is purified by Protein A chromatography. KO validated. Works in IHC, ICC, ELISA.

Anti-Nav1.6 Na+ Channel Antibody (BSA and Azide free)

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Species Reactivity

Feline, Human, Mouse, Rat

Applications

ELISA, ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Biotin

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Data Sheet

KO Validated

SKU: 75-026-CF

Volume: 100 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Nav1.6 Na+ channel

Scientific Background

Nav1.6 Na+ channel (sodium channel, voltage-gated, type 8, alpha subunit/ SCN8A) is a member of voltage-gated sodium ion channel subunit family. It is encoded by gene Scn8a in human.The channel switches between open and close conformation in response to the voltage difference accross the membrane. Nav1.6 Na+ channel is located at the nodes of Ranvier. It heavily participates in the regulation of nerve conduction velocity. It has been shown that Nav1.6 Na+ channel loss in roddents induces paralysis due to the failure of the neuromuscular junction (Wagnon et al., 2016).

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.6-1.0 mg/mL

Clonality

Monoclonal

Clone

K87A/10

Isotype

IgG1

Applications

ELISA, ICC, IHC

Host Species

Mouse

Gene Name

Scn8a

Molecular Weight

<200 kDa

Immunogen

Synthetic peptide 459-476 (intracellular interdomain loop I-II) of rat Nav1.6 (accession number O88420)

Immunogen Species

Rat

Species Reactivity

Feline, Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and buffer exchanged into 1X PBS. Purified mAbs are >90% specific antibody.

Buffer

PBS

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Sodium channel protein type 8 subunit alpha (Peripheral nerve protein type 4) (PN4) (Sodium channel 6) (NaCh6) (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6)

UniProt ID

O88420

Shipping

Shipped on ice packs

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Anti-Nav1.6 Na+ Channel Antibody (BSA and Azide free) (K87A/10)

SKU: 75-026-CF

Product Details

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