Human Mouse Rat
ICC IHC WB
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. It has recently been demonstrated that AMPK binds directly to GABAB receptors.
Fusion protein amino acids 861-912 of rat GABABR2 (also known as gammaaminobutyric acid type B receptor subunit 2, GABA-B receptor 2, Gb2, Gprotein coupled receptor 51 or GPR51, accession number NP_113990); Mouse: 100% identity (52/52 amino acids identical); Human: 100% identity (52/52 amino acids identical); Less than 12% identity with GABABR1
No cross-reactivity against GABABR1
GABBR2 GPR51 GPRC3B
TC Supernatant: AB_10672297
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.