Anti-GABA-B-R2 Antibody (N81/37)

Name: Anti-GABA-B-R2 Antibody
Brand: NeuroMab
SKU: 75-125
Price: 337.0 USD
Availability: InStock

Our mouse GABA(B)R2 monoclonal antibody from NeuroMab is produced in-house from clone N81/37. It detects human, mouse, and rat GABA(B)R2 and is purified by Protein A chromatography. Works in WB, IHC, IP, EM, ELISA.

$Immunoblot against membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with N81/37 (left) or N52A/42 (right) TC supe.$

$Immunoblot against brain membrane fractions from rat (RBM) and from GABABR2 knockout (KO) and wild-type (WT) mice probed with N81/37 (left) or N52A/42 (right) TC supe. Mouse brains courtesy of Joshua Walker and Stephen Moss (Tufts).$

Electron micrograph of N81/37 labelling in stratum radiatum of mouse hippocampal CA1 using a pre-embedding immunogold method. Immunoparticles are seen at postsynaptic sites (arrows) along the extrasynaptic plasma membrane of dendritic spines (s) and shafts of pyramidal cells forming synaptic contacts with excitatory axon terminals (b), and at presynaptic sites (arrowheads) in excitatory axon terminals (b). Image courtesy of Rafael Lujan (Universidad de Castilla-La Mancha).

Immunoblot against membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with N81/37 (left) or N52A/42 (right) TC supe.

Click on image to zoom

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, EM, IHC, IP, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

Go to Full Product Details

Data Sheet

KO Validated

SKU: 75-125

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

GABA(B)R2

Scientific Background

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. It has recently been demonstrated that AMPK binds directly to GABAB receptors.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N81/37

Isotype

IgG1

Applications

ELISA, EM, IHC, IP, WB

Host Species

Mouse

Gene Name

GABBR2 GPR51 GPRC3B

Molecular Weight

105 kDa

Immunogen

Fusion protein amino acids 861-912 of human GABABR2 (accession number NP_113990) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2278802

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.52

Conjugate

Unconjugated

Specificity

No cross-reactivity against GABABR1

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20)

UniProt ID

O75899

Shipping

Shipped on ice packs

Recover password

Create my account

Anti-GABA-B-R2 Antibody (N81/37)

SKU: 75-125

Product Details

Bulk Order Anti-GABA-B-R2 Antibody

Related Products

Recently Viewed