Anti-GABA-B-R2 Antibody Biotin Conjugate (N81/37)

Name: Anti-GABA-B-R2 Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-125-BTN
Price: 543.0 USD
Availability: InStock

Our mouse GABA(B)R2 biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone N81/37. It detects human, mouse, and rat GABA(B)R2 and is purified by Protein A chromatography. KO validated. Works in ELISA, IHC, WB, IP.

Anti-GABA-B-R2 Antibody Biotin Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, IP, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

KO Validated

SKU: 75-125-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

GABA(B)R2

Scientific Background

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. It has recently been demonstrated that AMPK binds directly to GABAB receptors.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N81/37

Isotype

IgG1

Applications

ELISA, IHC, IP, WB

Host Species

Mouse

Gene Name

GABBR2 GPR51 GPRC3B

Molecular Weight

105 kDa

Immunogen

Fusion Protein Amino acids 861-912 of human GABABR2 (accession number NP_113990) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

No cross-reactivity against GABABR1

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

BcDNA:GH07312 antibody; Gamma-aminobutyric acid type B receptor subunit 2; CG6706 antibody; GABA-B receptor 2; CT20836 antibody; GABA-B-R2; D Gaba2 antibody; GABA-BR2; FLJ36928 antibody; GABABR2; G protein coupled receptor 51 antibody; Gb2; G-protein coupled receptor 51 antibody; G-protein coupled receptor 51; GAB B R2 antibody; HG20; GABA B R2 antibody; GABA B receptor 2 antibody; GABA-B receptor 2 antibody; GABA-B-R2 antibody; GABA-BR2 antibody; GABAB R2 antibody; GABABR 2 antibody; GABABR2 antibody; GABB R2 antibody; GABBR 2 antibody; Gabbr2 antibody; GABR2_HUMAN antibody; Gamma aminobutyric acid B receptor 2 antibody; Gamma aminobutyric acid GABA B receptor 2 antibody; Gamma aminobutyric acid type B receptor subunit 2 antibody; Gamma-aminobutyric acid type B receptor subunit 2 antibody; Gb 2 antibody; Gb2 antibody; GH07312 antibody; GPR 51 antibody; GPR51 antibody; GPRC 3B antibody; GPRC3B antibody; HG 20 antibody; HG20 antibody; HRIHFB2099 antibody; Metabotropic GABA B receptor subtype 2 antibody; OTTHUMP00000021776 antibody; OTTHUMP00000063797 antibody; R2 SUBUNIT antibody

UniProt ID

O75899
UniProt Summary: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable).

NCBI Gene ID

9568

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Anti-GABA-B-R2 Antibody Biotin Conjugate (N81/37)

SKU: 75-125-BTN

Product Details

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