Anti-Pan-GRK FL490 Conjugate (N145/20)

Name: Anti-Pan-GRK FL490 Conjugate
Brand: NeuroMab
SKU: 75-179-FL490
Price: 460.0 USD
Availability: InStock

Our Anti-Pan-GRK mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N145/20. It detects human, mouse, and rat Pan-GRK, and is purified by Protein A chromatography. It is great for use in ICC.

Species Reactivity

Human, Mouse, Rat

Applications

ICC

Host Species

Mouse

Available Conjugates

Unconjugated

550

594

650

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Data Sheet

SKU: 75-179-FL490

Volume: 200 µL

Variant

Price:

$460.00

Quantity:

Product Details

Target

Pan-GRK

Target Description

G protein-coupled receptor (GPCR) kinases (GRKs), are important regulators of GPCR function and mediate receptor desensitization, internalization, and signaling. Several non-GPCR proteins also serve as GRK substrates, and GRKs have been shown to have kinase-independent functions through regulation of receptors and effectors. These proteins are members of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. GRKs phosphorylate activated forms of G protein-coupled receptors to regulate their signaling.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N145/20

Isotype

IgG1

Applications

ICC

Host Species

Mouse

Gene Name

Grk5 Gprk5 Grk6 Gprk6

Molecular Weight

70 kDa

Antigen

Fusion protein amino acids 381-590 (C-terminus) of mouse GRK5 (accession number Q8VEB1) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2939660

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

Cross-reacts with GRK6

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5) G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)

UniProt Details

UniProt (Human): P34947
UniProt (Immunogen Species): Q8VEB1

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Anti-Pan-GRK FL490 Conjugate (N145/20)

SKU: 75-179-FL490

Product Details

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