G protein-coupled receptor (GPCR) kinases (GRKs), are important regulators of GPCR function and mediate receptor desensitization, internalization, and signaling. Several non-GPCR proteins also serve as GRK substrates, and GRKs have been shown to have kinase-independent functions through regulation of receptors and effectors. These proteins are members of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. GRKs phosphorylate activated forms of G protein-coupled receptors to regulate their signaling.
Grk5 Gprk5 Grk6 Gprk6
Fusion protein amino acids 381-590 (C-terminus) of mouse GRK5 (also known as G protein-coupled receptor kinase 5 and Gprk5, accession number Q8VEB1); Rat: 99% identity (208/210 amino acids identical); Human: 91% identity (193/210 amino acids identical); Greater than 55% identity with GRK6 and GRK4; Greater than 40% identity with GRK7 and RK
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Cross-reacts with GRK6
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.