Tissue and transfected cell immunoblot: extracts of rat brain membrane (RBM) and COS cells transiently transfected with Myc-tagged Neuregulin-CRD (NRG-CRD) or untagged Kv2.1 plasmid and probed with N126B/31 (left), 19E10 (middle) and K89/41 (right) TC supe.
Anti-Neuregulin-CRD (Cysteine-Rich Domain, Type III) Antibody
Neuregulin-CRD (Cysteine-rich domain, Type III)
Neuregulin 1 is encoded by the gene NRG1. NRG1 is a member of the neuregulin family. NRG1 is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. NRG1 is expressed in the nervous system, intestine, muscle, and heart. Diseases associated with NRG1 include Schizphrenia 6 and Lung Cancer.
Fusion protein amino acids 1-75 (membrane-associated N-terminus) of human Neuregulin-1 (also known as NRG1, Neu differentiation factor, NDF, Heregulin, HRG, HGL, Breast cancer cell differentiation factor p45, Acetylcholine receptor-inducing activity, ARIA, Glial growth factor, GGF, Sensory and motor-neuron-derived factor or SMDF, accession number Q96IB3); Mouse: 85% identity (64/75 amino acids identical); Rat: 82% identity (63/76 amino acids identical)
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
No cross-reactivity reported
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.