Adult rat optic nerve immunofluorescence staining K87A/10=red Rabbit anti-Caspr=green Image courtesy of Dr. Matthew Rasband (Baylor College of Medicine).
Anti-Nav1.6 Na+ Channel Antibody
Nav1.6 Na+ channel
Nav1.6 Na+ channel (sodium channel, voltage-gated, type 8, alpha subunit/ SCN8A) is a member of voltage-gated sodium ion channel subunit family. It is encoded by gene Scn8a in human.The channel switches between open and close conformation in response to the voltage difference accross the membrane. Nav1.6 Na+ channel is located at the nodes of Ranvier. It heavily participates in the regulation of nerve conduction velocity. It has been shown that Nav1.6 Na+ channel loss in roddents induces paralysis due to the failure of the neuromuscular junction (Wagnon et al., 2016).
K87A/10 does not work for immunoblotting
Synthetic peptide 459-476 (intracellular interdomain loop I-II) of rat Nav1.6 (accession number O88420); Human: 88% identity (16/18 amino acids identical); Mouse: 100% identity (18/18 amino acids identical)
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
No cross-reactivity reported
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
24 months from opening
Sodium channel protein type 8 subunit alpha (Peripheral nerve protein type 4) (PN4) (Sodium channel 6) (NaCh6) (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6)