Anti-Nav1.6 Na+ Channel Antibody (K87A/10)

from NeuroMab Datasheet KO Validated Trial Size

Primary Antibody
Human, Mouse, Rat
K87A/10
ICC, IHC, IP, WB
Mouse
Purified
Scn8a
<200 kDa

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Anti-Nav1.6 Na+ Channel Antibody
SKU: 75-026

Volume: 100 µL
Price:
Sale price$361


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Product Specific References for Applications and Species

Immunocytochemistry: Human
PMID Dilution Publication
269857381:200González-Burguera, I., et al. 2016. Highly efficient generation of glutamatergic/cholinergic NT2-derived postmitotic human neurons by short-term treatment with the nucleoside analogue cytosine β-D-arabinofuranoside. . Stem cell research, 541-551.
Immunocytochemistry: Mouse
PMID Dilution Publication
32375064not listedWeinstock, N.I., et al. 2020. Macrophages expressing GALC improve peripheral Krabbe disease by a mechanism independent of cross-correction.. Neuron, 65-81.
307962901:300Reijntjes, D.O., et al. 2019. Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice. . Scientific reports, 1-18.
280917221:200Hatch, R.J., et al. 2017. Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment.. Acta neuropathologica, 717-730.
208880801:500Shepherd, M.N., et al. 2012. Paranodal reorganization results in the depletion of transverse bands in the aged central nervous system.. Neurobiology of Aging, 203-e13.
208614681:150Tong, M., et al. 2010. The intrinsic electrophysiological properties of neurons derived from mouse embryonic stem cells overexpressing neurogenin-1.. American Journal of Physiology-Cell Physiology, C1335-C1344.
201338731:100Brackenbury, W.J., et al. 2010. Functional reciprocity between Na+ channel Nav1. 6 and ß1 subunits in the coordinated regulation of excitability and neurite outgrowth. . Proceedings of the National Academy of Sciences, 2283-2288.
192618671:100Sharkey, L.M., et al. 2009. The ataxia3 mutation in the N-terminal cytoplasmic domain of sodium channel Na(v)1.6 disrupts intracellular trafficking.. Journal of Neuroscience, 2733-2741.
190132471:200O'Malley, H.A., et al. 2009. Loss of Na+ channel ß2 subunits is neuroprotective in a mouse model of multiple sclerosis. . Molecular and Cellular Neuroscience, 143-155.
Immunocytochemistry: Rat
PMID Dilution Publication
264081731:200Barbosa, C., et al. 2015. Navß4 regulates fast resurgent sodium currents and excitability in sensory neurons.. Molecular Pain, s12990-015.
228851081:100Devaux, J.J., et al. 2012. Antibodies to gliomedin cause peripheral demyelinating neuropathy and the dismantling of the nodes of Ranvier.. The American Journal of Pathology, 1402-1413.
Immunohistochemistry: Feline
PMID Dilution Publication
215436021:100Meehan, C.F., et al. 2011. Dendrite-derived supernumerary axons on adult axotomized motor neurons possess proteins that are essential for the initiation and propagation of action potentials and synaptic vesicle release.. Journal of Neuroscience, 6732-6740.
Immunohistochemistry: Human
PMID Dilution Publication
20838243not listedHowell, O.W., et al. 2010. Activated microglia mediate axoglial disruption that contributes to axonal injury in multiple sclerosis.. Journal of Neuropathology & Experimental Neurology, 1017-1033.
Immunohistochemistry: Mouse
PMID Dilution Publication
351636231:300Marosi, M., et al. 2022. Inhibition of the Akt/PKB Kinase Increases Nav1.6-Mediated Currents and Neuronal Excitability in CA1 Hippocampal Pyramidal Neurons. International journal of molecular sciences, 1700.
348253951:100Newville, J., et al. 2020. Persistent myelin abnormalities in a third trimester‐equivalent mouse model of fetal alcohol spectrum disorder. . Alcoholism: Clinical and Experimental Research, 77-86.
32142125not listedKawamura, A., et al. 2020. Oligodendrocyte dysfunction due to Chd8 mutation gives rise to behavioral deficits in mice.. Human molecular genetics, 1274-1291.
319336261:300Alshammari, M.A., et al. 2019. Changes in the Fluorescence Tracking of NaV1.6 Protein Expression in a BTBR T+Itpr3tf/J Autistic Mouse Model. Neural Plasticity, 4893103.
30125271not listedNunes, D., et al. 2018. Axonal sodium channel NaV1. 2 drives granule cell dendritic GABA release and rapid odor discrimination. . PLoS biology, e2003816.
285956501:200Benusa, S.D., et al. 2017. Acute neuroinflammation induces AIS structural plasticity in a NOX2-dependent manner. . Journal of neuroinflammation, 1-14.
283555691:5 (supe)Morelli, K.H., et al. 2017. Severity of demyelinating and axonal neuropathy mouse models is modified by genes affecting structure and function of peripheral nodes. . Cell reports, 3178-3191.
282835811:500Satake, T., et al. 2017. MTCL1 plays an essential role in maintaining Purkinje neuron axon initial segme. The EMBO journal, 1227-1242.
276297141:100Kim, S., et al. 2016. Schwann cell O-GlcNAc glycosylation is required for myelin maintenance and axon integrity.. Journal of Neuroscience, 9633-9646.
27581456not listedMarin, M.A., et al. 2016. Reassembly of excitable domains after CNS axon regeneration.. Journal of Neuroscience, 9148-9160.
269090211:300Alshammari, M.A., et al. 2016. Improved methods for fluorescence microscopy detection of macromolecules at the axon initial segment. . Frontiers in cellular neuroscience, 5.
268079881:200Jones, J.M., et al. 2016. Single amino acid deletion in transmembrane segment D4S6 of sodium channel Scn8a (Nav1. 6) in a mouse mutant with a chronic movement disorder.. Neurobiology of disease, 36-45.
25653382not listedBaalman, K., et al. 2015. Axon initial segment-associated microglia.. Journal of Neuroscience, 2283-2292.
25362471not listedChang, K.J., et al. 2014. Glial ankyrins facilitate paranodal axoglial junction assembly.. Nature Neuroscience, 1673-81.
238918061:1000Xiao, M., et al. 2013. FGF14 localization and organization of the axon initial segment. . Molecular and Cellular Neuroscience, 393-403.
238646791:200Ruff, C.A., et al. 2013. Effects of adult neural precursor-derived myelination on axonal function in the perinatal congenitally dysmyelinated brain: optimizing time of intervention, developing accurate prediction models, and enhancing performance.. Journal of Neuroscience, 11899-11915.
230909521:250Sun, W., et al. 2013. Aberrant sodium channel activity in the complex seizure disorder of Celf4 mutant mice.. The Journal of Physiology, 241-255.
22492029not listedButtermore, E.D., et al. 2012. Pinceau organization in the cerebellum requires distinct functions of neurofascin in Purkinje and basket neurons during postnatal development.. Journal of Neuroscience, 4724-4742.
21958379not listedDuflocq, A., et al. 2011. Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B.. BMC Biology, 1-19.
215252781:100Binder, E., et al. 2011. Peripheral nervous system progenitors can be reprogrammed to produce myelinating oligodendrocytes and repair brain lesions.. Journal of Neuroscience, 6379-6391.
20838243not listedHowell, O.W., et al. 2010. Activated microglia mediate axoglial disruption that contributes to axonal injury in multiple sclerosis.. Journal of Neuropathology & Experimental Neurology, 1017-1033.
20628201not listedWimmer, V.C., et al. 2010. Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus. . The Journal of clinical investigation, 2661-2671.
20375142not listedWimmer, V.C., et al. 2010. Axon initial segment dysfunction in epilepsy. . The Journal of physiology, 1829-1840.
201730791:200Osorio, N., et al. 2010. Persistent Nav1.6 current at axon initial segments tunes spike timing of cerebellar granule cells.. The Journal of Physiology, 651-670.
201338731:100Brackenbury, W.J., et al. 2010. Functional reciprocity between Na+ channel Nav1. 6 and ß1 subunits in the coordinated regulation of excitability and neurite outgrowth. . Proceedings of the National Academy of Sciences, 2283-2288.
186615561:1000Desai, M.K., et al. 2009. Triple‐transgenic Alzheimer's disease mice exhibit region‐specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology. . Glia, 4-65.
189308251:1000Shakkottai, V.G., et al. 2008. FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons.. Neurobiology of Disease, 81-88.
18621130not listedDuflocq, A., et al. 2008. Nav1. 1 is predominantly expressed in nodes of Ranvier and axon initial segments. . Molecular and Cellular Neuroscience, 180-192.
185228481:200Windrem, M.S., et al. 2008. Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse.. Cell Stem Cell, 553-565.
Immunohistochemistry: Rat
PMID Dilution Publication
259482591:200Hirono, M., et al. 2015. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells.. Journal of Neuroscience, 7082-7094.
244779621:100King, A.N., et al. 2014. A unique ion channel clustering domain on the axon initial segment of mammalian neurons. . Journal of Comparative Neurology, 2594-2608.
217343021:200Lysakowski, A., et al. 2011. Molecular microdomains in a sensory terminal, the vestibular calyx ending.. Journal of Neuroscience, 10101-10114.
191181651:500Lorincz, A., et al. 2008. Cell-type-dependent molecular composition of the axon initial segment. . Journal of Neuroscience, 14329-14340.
187695611:500-1:1000Mojumder, D.K., et al. 2008. Subcellular compartmentalization of two calcium binding proteins, calretinin and calbindin-28 kDa, in ganglion and amacrine cells of the rat retina. . Molecular Vision, 1600.
Western Blot: Mouse
PMID Dilution Publication
319336261:500Alshammari, M.A., et al. 2019. Changes in the Fluorescence Tracking of NaV1.6 Protein Expression in a BTBR T+Itpr3tf/J Autistic Mouse Model. Neural Plasticity, 4893103.
30125271not listedNunes, D., et al. 2018. Axonal sodium channel NaV1. 2 drives granule cell dendritic GABA release and rapid odor discrimination. . PLoS biology, e2003816.
294910111:200Zhou, L., et al. 2018. Celecoxib ameliorates seizure susceptibility in autosomal dominant lateral temporal epilepsy. . Journal of Neuroscience, 3346-3357.
26406915not listedBrügger, V., et al. 2015. HDAC1/2-Dependent P0 Expression Maintains Paranodal and Nodal Integrity Independently of Myelin Stability through Interactions with Neurofascins.. PLoS Biology, e1002258.
25362471not listedChang, K.J., et al. 2014. Glial ankyrins facilitate paranodal axoglial junction assembly.. Nature Neuroscience, 1673-81.
190132471:200O'Malley, H.A., et al. 2009. Loss of Na+ channel ß2 subunits is neuroprotective in a mouse model of multiple sclerosis. . Molecular and Cellular Neuroscience, 143-155.
168707431:100Lopez-Santiago, L.F., et al. 2006. Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain.. Journal of Neuroscience, 7984-7994.
Additional Publications: Unspecified
PMID Publication
30500400Brasileiro, A.D., et al. 2019. Effects of diabetes mellitus on myenteric neuronal density and sodium channel expression in the rat ileum. . Brain Research, 1-9.
27100937Clark, K.C., et al. 2016. Compromised axon initial segment integrity in EAE is preceded by microglial reactivity and contact. Glia, 64(7), pp.1190-1209.. Glia, 1190-1209.
25421039Wimmer, V.C., et al. 2015. Sodium channel ß1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain.. Journal of Comparative Neurology, 814-830.
23025758Baalman, K.L., et al. 2013. Blast wave exposure impairs memory and decreases axon initial segment length.. Journal of Neurotrauma, 741-751.
19800949Crawford, D.K., et al. 2009. Functional recovery of callosal axons following demyelination: a critical window.. Neuroscience, 1407-1421.
18079688Mojumder, D.K., et al. 2007. Voltage-gated sodium channel alpha-subunits Na(v)1.1, Na(v)1.2, and Na(v)1.6 in the distal mammalian retina.. Molecular Vision, 2163-2182.
17884088Lopez-Santiago, L.F., et al. 2007. Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals. . Journal of molecular and cellular cardiology, 636-647.
16817858Rush, A.M., et al. 2006. Differential modulation of sodium channel Na(v)1.6 by two members of the fibroblast growth factor homologous factor 2 subfamily.. European Journal of Neuroscience, 2551-2562.

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