Anti-LAR/PTPRF (Receptor-Type Tyrosine-Protein Phosphatase) Antibody FL490 Conjugate (N165/38)

Name: Anti-LAR/PTPRF (Receptor-Type Tyrosine-Protein Phosphatase) Antibody FL490 Conjugate
Brand: NeuroMab
SKU: 75-193-FL490
Price: 486.0 USD
Availability: InStock

Our mouse LAR/PTPRF (Receptor-type tyrosine-protein phosphatase) FL490 conjugate monoclonal antibody from NeuroMab is produced in-house from clone N165/38. It detects human, mouse, and rat LAR/PTPRF (Receptor-type tyrosine-protein phosphatase) and is purified by Protein A chromatography. Works in ICC.

Anti-LAR/PTPRF (Receptor-Type Tyrosine-Protein Phosphatase) Antibody FL490 Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ICC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-193-FL490

Volume: 200 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

LAR/PTPRF (Receptor-type tyrosine-protein phosphatase)

Scientific Background

Receptor-type tyrosine-protein phosphatase F or Leukocyte Common Antigen Related protein is encoded by the gene PTPRF and is a member of the protein tyrosine phosphatase (PTP) family. PRPRF is a transmembrane protein involved in regulation of insulin signaling, cell proliferation and cell migration. PTPRF functions in the regulation of epithelial cell-cell contacts at adherens junctions, as well as in the control of beta-catenin signaling. PTPRF is ubiquitously expressed. Diseases associated with PTPRF include Aplasia or hypoplasia of the breasts and/or nipples 2

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N165/38

Isotype

IgG2a

Applications

ICC

Host Species

Mouse

Gene Name

PTPRF LAR

Molecular Weight

85 kDa (full-length is 210 kDa, smaller due to proteolysis into P-subunit containing transmembrane and intracellular domains)

Immunogen

Fusion protein amino acids 1315-1607 (cytoplasmic C-terminus) of human LAR (accession number P10586) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2939712

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

Does not cross-react with PTPRD or PTPRS

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

BNAH2; Receptor-type tyrosine-protein phosphatase F; EC 3.1.3.48; LCA-homolog; Leukocyte common antigen related; leukocyte antigen-related (LAR PTP receptor; LAR; leukocyte antigen-related tyrosine phosphatase; receptor-linked protein-tyrosine phosphatase LAR

UniProt ID

P10586
UniProt Summary: Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.; The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.

NCBI Gene ID

5792

Shipping

Shipped on ice packs

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Anti-LAR/PTPRF (Receptor-Type Tyrosine-Protein Phosphatase) Antibody FL490 Conjugate (N165/38)

SKU: 75-193-FL490

Product Details

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