Receptor-type tyrosine-protein phosphatase F or Leukocyte Common Antigen Related protein is encoded by the gene PTPRF and is a member of the protein tyrosine phosphatase (PTP) family. PRPRF is a transmembrane protein involved in regulation of insulin signaling, cell proliferation and cell migration. PTPRF functions in the regulation of epithelial cell-cell contacts at adherens junctions, as well as in the control of beta-catenin signaling. PTPRF is ubiquitously expressed. Diseases associated with PTPRF include Aplasia or hypoplasia of the breasts and/or nipples 2
85 kDa(full-length is 210 kDa, smaller due to proteolysis into P-subunit containing transmembrane and intracellular domains)
Fusion protein amino acids 1315-1607 (cytoplasmic C-terminus) of human LAR (also known as Leukocyte antigen related, Leukocyte common antigen-related phosphatase, Receptor-type tyrosine-protein phosphatase F and PTPRF, accession number P10586); Rat: 97% identity (286/293 amino acids identical); Mouse: 97% identity (285/293 amino acids identical); Greater than 80% identity with PTPRD and PTPRS; Greater than 50% identity with PTPRM and PTPRK
Human, Mouse, Rat
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