Bulk Order Anti-Kir6.1 Potassium Channel Antibody FL550 Conjugate
Kir6.1 potassium channel
ATP-sensitive inward rectifier potassium channel 8 or Kir6.1 is encoded by the gene Kcnj8. Kir6.1 is an integral membrane protein which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. In this manner, Kir6.1 plays a role in modifying Ca2+ release from intracellular stores. Kir6.1 is expressed in many tissues including in pancreatic islets, brain, skeletal muscle and heart and found distributed in mitochondria and endoplasmic reticulum. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS) and Cantu Syndrome.
Purified by Protein A chromatography
Fusion protein amino acids 306-424 (cytoplasmic C-terminus) of rat Kir6.1 (accession number Q63664) produced recombinantly in E. Coli
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.
PBS with 0.09% azide
FL550 Ex: 550 nm, Em: 575 nm
Does not cross-react with Kir6.2
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.