ATP-sensitive inward rectifier potassium channel 8 or Kir6.1 is encoded by the gene Kcnj8. Kir6.1 is an integral membrane protein which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. In this manner, Kir6.1 plays a role in modifying Ca2+ release from intracellular stores. Kir6.1 is expressed in many tissues including in pancreatic islets, brain, skeletal muscle and heart and found distributed in mitochondria and endoplasmic reticulum. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS) and Cantu Syndrome.
ICC, IHC, WB
Fusion protein amino acids 306-424 (cytoplasmic C-terminus) of rat Kir6.1 (also known as ATPsensitive inward rectifier potassium channel 8, Potassium channel inwardly rectifying subfamily J member 8, uKATP-1 and Kcnj8, accession number Q63664); Mouse: 99% identity (118/119 amino acids identical); Human: 96% identity (115/119 amino acids identical); 50% identity with Kir6.2
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Does not cross-react with Kir6.2
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.