Anti-Kir6.1 Potassium Channel Antibody (N366/60)

Name: Anti-Kir6.1 Potassium Channel Antibody
Brand: NeuroMab
SKU: 75-394
Price: 285.0 USD
Availability: InStock

from NeuroMab Datasheet

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Clonality

Monoclonal

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnj8

Molecular Weight

45 kDa

Go to Full Product Details

Immunoblot against extracts of COS cells transiently transfected with Myc-tagged Kir6.1, HA- tagged Kir6.2 or untagged Kv2.1 plasmid probed with N366/60 (left) or N52A/42 (right) TC supe.

Product Details

Target

ATP-sensitive inward rectifier potassium channel 8 (Inward rectifier K(+) channel Kir6.1) (Potassium channel, inwardly rectifying subfamily J member 8) (uKATP-1)

Target Description

ATP-sensitive inward rectifier potassium channel 8 or Kir6.1 is encoded by the gene Kcnj8. Kir6.1 is an integral membrane protein which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. In this manner, Kir6.1 plays a role in modifying Ca2+ release from intracellular stores. Kir6.1 is expressed in many tissues including in pancreatic islets, brain, skeletal muscle and heart and found distributed in mitochondria and endoplasmic reticulum. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS) and Cantu Syndrome.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N366/60

Isotype

IgG2a

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnj8

Molecular Weight

45 kDa

Antigen

Fusion protein amino acids 306-424 (cytoplasmic C-terminus) of rat Kir6.1 (also known as ATPsensitive inward rectifier potassium channel 8, Potassium channel inwardly rectifying subfamily J member 8, uKATP-1 and Kcnj8, accession number Q63664); Mouse: 99% identity (118/119 amino acids identical); Human: 96% identity (115/119 amino acids identical); 50% identity with Kir6.2

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2491087

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Conjugate

Unconjugated

Specificity

Does not cross-react with Kir6.2

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

ATP-sensitive inward rectifier potassium channel 8 (Inward rectifier K(+) channel Kir6.1) (Potassium channel, inwardly rectifying subfamily J member 8) (uKATP-1)

UniProt Details

UniProt (Human): Q15842
UniProt (Immunogen Species): Q63664

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Anti-Kir6.1 Potassium Channel Antibody (N366/60)

Anti-Kir6.1 Potassium Channel Antibody
SKU: 75-394

Product Details

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Anti-Kir6.1 Potassium Channel Antibody (N366/60)

Anti-Kir6.1 Potassium Channel Antibody SKU: 75-394

Product Details

Anti-Kir6.1 Potassium Channel Antibody
SKU: 75-394