Anti-KCC2 Antibody Biotin Conjugate (N1/12)

Name: Anti-KCC2 Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-013-BTN
Price: 543.0 USD
Availability: InStock

Our mouse KCC2 biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone N1/12. It detects finch, human, mouse, and rat KCC2 and is purified by Protein A chromatography. Works in ELISA, IHC, ICC, WB.

Anti-KCC2 Antibody Biotin Conjugate

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Species Reactivity

Finch, Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 75-013-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

KCC2

Scientific Background

KCC2 or Potassium-chloride transporter member 5 is a member of the chloride potassium symporter family. KCC2 is a neuron-specific membrane protein encoded by the SLC12A5 gene in humans. The protein colocalizes with GABAA receptors and has for function to mediates electroneutral potassium-chloride cotransport in mature neurons to mainatin the Cl- homeostasis. KCC2 is widely expressed throughout the central nervous system, especially the hippocampus, hypothalamus, brainstem, and motoneurons of the ventral spinal cord. KCC2 is a neuronal marker that is often used to measure post-synaptic inhibition through GABAA receptors.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N1/12

Isotype

IgG2a

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Slc12a5 Kcc2 Kiaa1176

Molecular Weight

140 kDa

Immunogen

Fusion Protein Amino acids 932-1043 (intracellular carboxyl terminus) of rat KCC2 (accession number Q63633) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Finch, Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Electroneutral potassium chloride cotransporter 2 antibody; Solute carrier family 12 member 5; Electroneutral potassium-chloride cotransporter 2 antibody; Electroneutral potassium-chloride cotransporter 2; Erythroid K Cl cotransporter 2 antibody; K-Cl cotransporter 2; Furosemide sensitive K Cl cotransporter antibody; mKCC2; hKCC2 antibody; Neuronal K-Cl cotransporter; K-Cl cotransporter 2 antibody; KCC 2 antibody; KCC2 antibody; KIAA1176 antibody; Neuronal K Cl cotransporter antibody; Neuronal K-Cl cotransporter antibody; Potassium Chloride Cotransporter antibody; Potassium chloride transporter 5 antibody; rKCC2 antibody; S12A5 antibody; S12A5_HUMAN antibody; SLC12A5 antibody; Solute carrier family 12 (potassium chloride transporter member 5 antibody; Solute carrier family 12 member 5 antibody

UniProt ID

Q63633
UniProt Summary: Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation.

NCBI Gene ID

171373

Shipping

Shipped on ice packs

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Anti-KCC2 Antibody Biotin Conjugate (N1/12)

SKU: 75-013-BTN

Product Details

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