KCC2 or Potassium-chloride transporter member 5 is a member of the chloride potassium symporter family. KCC2 is a neuron-specific membrane protein encoded by the SLC12A5 gene in humans. The protein colocalizes with GABAA receptors and has for function to mediates electroneutral potassium-chloride cotransport in mature neurons to mainatin the Cl- homeostasis. KCC2 is widely expressed throughout the central nervous system, especially the hippocampus, hypothalamus, brainstem, and motoneurons of the ventral spinal cord. KCC2 is a neuronal marker that is often used to measure post-synaptic inhibition through GABAA receptors.
Purified
1 mg/mL
Monoclonal
N1/12
IgG2a
IHC, IP, WB
Mouse
Slc12a5 Kcc2 Kiaa1176
140 kDa
Fusion protein amino acids 932-1043 (intracellular carboxyl terminus) of rat KCC2 (accession number Q63633); Human: 96% identity (108/112 residues identical); Mouse=95% identity (107/112 residues identical); Less than 20% identity with KCC1, KCC3, KCC4
Human, Mouse, Rat
AB_10672851
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from opening
Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (mKCC2) (Neuronal K-Cl cotransporter)
