Anti-KCC2 Antibody (N1/12)


Primary Antibody
Human, Mouse, Rat, Zebrafish
N1/12
IHC, IP, PLA, WB
Mouse
Purified
Slc12a5 Kcc2 Kiaa1176
140 kDa

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Anti-KCC2 Antibody
SKU: 75-013

Volume: 100 µL
Price:
Sale price$361


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Product Specific References for Applications and Species

Immunocytochemistry: Mouse
PMID Dilution Publication
335399181:500-1:1000Kontou, G., et al. 2021. KCC2 is required for the survival of mature neurons but not for their development. . Journal of Biological Chemistry, 100364.
33192291not listedSmalley, J.L., et al. 2020. Isolation and characterization of multi-protein complexes enriched in the K-Cl Co-transporter 2 from brain plasma membranes. . Frontiers in Molecular Neuroscience, 563091.
302016061:1000Cordshagen, A., et al. 2018. Phosphoregulation of the intracellular termini of K+-Cl− cotransporter 2 (KCC2) enables flexible control of its activity. . Journal of Biological Chemistry, 16984-16993.
Immunocytochemistry: Rat
PMID Dilution Publication
324130571:1000Zhang, J., et al. 2020. Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1. . PloS one, e0232967.
224146951:500Döding, A., et al. 2012. KCC2 transport activity requires the highly conserved L₆₇₅ in the C-terminal β1 strand.. Biochemical and Biophysical Research Communications, 492-497.
Immunohistochemistry: Mouse
PMID Dilution Publication
28054918not listedChen, M., et al. 2017. APP modulates KCC2 expression and function in hippocampal GABAergic inhibition.. Elife, e20142.
246390011:300Markkanen, M., et al. 2014. Distribution of neuronal KCC2a and KCC2b isoforms in mouse CNS.. Journal of Comparative Neurology, 1897-1914.
226742551:200Sun, Y.G., et al. 2012. GABAergic synaptic transmission triggers action potentials in thalamic reticular nucleus neurons.. Journal of Neuroscience, 7782-7790.
Immunohistochemistry: Rat
PMID Dilution Publication
311221431:40Lizhnyak, P.N., et al. 2019. Traumatic brain injury temporal proteome guides KCC2-targeted therapy. . Journal of neurotrauma, 3092-3102.
300550191:500Zhang, H., et al. 2018. Uncovering a critical period of synaptic imbalance during postnatal development of the rat visual cortex: role of brain‐derived neurotrophic factor. . The Journal of Physiology, 4511-4536.
224410381:500Liu, Q., et al. 2012. Postnatal development of Na(+)-K(+)-2Cl(-) co-transporter 1 and K(+)-Cl(-) co-transporter 2 immunoreactivity in multiple brain stem respiratory nuclei of the rat.. Neuroscience, 1-20.
19674083not listedBragin, D.E., et al. 2009. Development of epileptiform excitability in the deep entorhinal cortex after status epilepticus.. European Journal of Neuroscience, 611-624.
19001126not listedHedstrom, K.L., et al. 2008. AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity.. The Journal of Biology, 635-640.
Immunohistochemistry: Zebra Finch
PMID Dilution Publication
292187451:500-1:1500Vaaga, C.E., et al. 2018. Expression of the potassium‐chloride co‐transporter, KCC2, within the avian song system. . Journal of Comparative Neurology, 944-956.
Immunoprecipitation: Mouse
PMID Dilution Publication
33192291not listedSmalley, J.L., et al. 2020. Isolation and characterization of multi-protein complexes enriched in the K-Cl Co-transporter 2 from brain plasma membranes. . Frontiers in Molecular Neuroscience, 563091.
31615901not listedWatanabe, M., et al. 2019. Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival. . Science signaling, eaaw9315.
29028184not listedMahadevan, V., et al. 2017. Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition. . Elife, e28270.
249104355-10 ugMahadevan, V., et al. 2014. Kainate receptors coexist in a functional complex with KCC2 and regulate chloride homeostasis in hippocampal neurons. . Cell reports, 1762-1770.
205291231:100Horn, Z., et al. 2010. Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism.. European Journal of Neuroscience, 2142-2155.
Immunoprecipitation: Rat
PMID Dilution Publication
29216042not listedCardarelli, R.A., et al. 2017. The small molecule CLP257 does not modify activity of the K+–Cl− co-transporter KCC2 but does potentiate GABAA receptor activity. . Nature medicine, 1394-1396.
29092909not listedConway, L.C., et al. 2017. N-Ethylmaleimide increases KCC2 cotransporter activity by modulating transporter phosphorylation. . Journal of Biological Chemistry, 21253-21263.
240971885 ugGagnon, M., et al. 2013. Chloride extrusion enhancers as novel therapeutics for neurological diseases.. Nature Medicine, 1524-1528.
PLA: Mouse
PMID Dilution Publication
28054918not listedChen, M., et al. 2017. APP modulates KCC2 expression and function in hippocampal GABAergic inhibition.. Elife, e20142.
Western Blot: Human
PMID Dilution Publication
356787821ug/mlKüry, S., et al. 2022. Rare Pathogenic Variants in WNK3 Cause X-Linked Intellectual Disability. Genetics in Medicine, .
Western Blot: Mouse
PMID Dilution Publication
335399181:1000Kontou, G., et al. 2021. KCC2 is required for the survival of mature neurons but not for their development. . Journal of Biological Chemistry, 100364.
31615901not listedWatanabe, M., et al. 2019. Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival. . Science signaling, eaaw9315.
31615899not listedPisella, L.I., et al. 2019. Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology. . Science signaling, eaay0300.
28054918not listedChen, M., et al. 2017. APP modulates KCC2 expression and function in hippocampal GABAergic inhibition. . Elife, e20142.
26441539not listedMahadevan, V., et al. 2015. Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures.. Frontiers in Cellular Neuroscience, 368.
250667271:1000Campbell, S.L., et al. 2015. GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy.. Glia, 23-36.
249104351:500Mahadevan, V., et al. 2014. Kainate receptors coexist in a functional complex with KCC2 and regulate chloride homeostasis in hippocampal neurons. . Cell reports, 1762-1770.
244031441:500He, Q., et al. 2014. The developmental switch in GABA polarity is delayed in fragile X mice.. Journal of Neuroscience, 446-450.
28496181not listedKursan, S., et al. 2017. The neuronal K+ Cl− co-transporter 2 (Slc12a5) modulates insulin secretion. . Scientific reports, 1-14.
Western Blot: Rat
PMID Dilution Publication
31911626not listedZhang, J., et al. 2020. Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a. . Nature communications, 1-17.
311221431:300Lizhnyak, P.N., et al. 2019. Traumatic brain injury temporal proteome guides KCC2-targeted therapy. . Journal of neurotrauma, 3092-3102.
282358051:1000Pressey, J.C., et al. 2017. A kainate receptor subunit promotes the recycling of the neuron-specific K+-Cl− co-transporter KCC2 in hippocampal neurons. . Journal of Biological Chemistry, 6190-6201.
220447361:250Reid, A.Y., et al. 2011. A prolonged experimental febrile seizure results in motor map reorganization in adulthood.. Neurobiology of Disease, 692-700.
196740831:1000Bragin, D.E., et al. 2009. Development of epileptiform excitability in the deep entorhinal cortex after status epilepticus.. European Journal of Neuroscience, 611-624.
176934021:1000Lee, H.H., et al. 2007. Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2.. The Journal of Biological Chemistry, 29777-29784.

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