Anti-KCC2 Antibody FL550 Conjugate (N1/12)

Name: Anti-KCC2 Antibody FL550 Conjugate
Brand: NeuroMab
SKU: 75-013-FL550
Price: 531.0 USD
Availability: InStock

Our Anti-KCC2 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N1/12. It detects human, mouse, rat, and zebrafish KCC2, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Human, Mouse, Rat, Zebrafish

Applications

ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

594

650

Carrier-Free

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Data Sheet

SKU: 75-013-FL550

Volume: 200 µL

Variant

Price:

$531.00

Quantity:

Ships: 1-5 business days

Product Details

Target

KCC2

Target Description

KCC2 or Potassium-chloride transporter member 5 is a member of the chloride potassium symporter family. KCC2 is a neuron-specific membrane protein encoded by the SLC12A5 gene in humans. The protein colocalizes with GABAA receptors and has for function to mediates electroneutral potassium-chloride cotransport in mature neurons to mainatin the Cl- homeostasis. KCC2 is widely expressed throughout the central nervous system, especially the hippocampus, hypothalamus, brainstem, and motoneurons of the ventral spinal cord. KCC2 is a neuronal marker that is often used to measure post-synaptic inhibition through GABAA receptors.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N1/12

Isotype

IgG2a

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Slc12a5 Kcc2 Kiaa1176

Molecular Weight

140 kDa

Antigen

Fusion protein amino acids 932-1043 (intracellular carboxyl terminus) of rat KCC2 (accession number Q63633) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat, Zebrafish

Antibody Registry ID

AB_2939113

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL550 Ex: 550 nm, Em: 575 nm

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (mKCC2) (Neuronal K-Cl cotransporter)

UniProt ID

Q63633

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Anti-KCC2 Antibody FL550 Conjugate (N1/12)

SKU: 75-013-FL550

Product Details

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