Our Anti-GABA(B)R1 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N93A/49. It is KO validated, detects human and mouse GABA(B)R1, and is purified by Protein A chromatography. It is great for use in IHC, ICC.
Gamma-aminobutyric acid type B receptor subunit 1 or GABA BR1 is encoded by the gene GABBR1. GABA BR1 is a subunit of the G-protein coupled receptor for the neurotransmitter GABA (gamma-aminobutyric acid). It will inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. GABA BR1 is highly expressed in many tissues including eye, atrium, ventricle, lung and colon. In brain, wide expression is seen with high levels in the cerebral cortical layers and hippocampus. Cellularly, it is found at the cell junction, synapse, the postsynaptic cell membrane and cytoplasmic vesicle membrane. Diseases associated with GABBR1 include Temporal Lobe Epilepsy and Persistent Vegetative State.
Purified by Protein A chromatography
Fusion protein amino acids 873-977 (cytoplasmic C-terminus) of rat GABABR1 (accession number Q9Z0U4) produced recombinantly in E. Coli
Chicken, Human, Mouse, Rabbit, Rat
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.
PBS with 0.09% azide
FL650 Ex: 655 nm, Em: 676 nm
No cross-reactivity against GABABR1
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
12 months from date of receipt
Shipped on ice packs
Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1)