Immunoblot versus crude membranes made from adult rat brain (RBM) or GABABR1 wild-type (WT) or knockout (KO) mice probed with N93A/49 (left) or K89/34 (right) TC supe. Mouse brains courtesy of Martin Gassmann and Bernhard Bettler (University of Basel).
Gamma-aminobutyric acid type B receptor subunit 1 or GABA BR1 is encoded by the gene GABBR1. GABA BR1 is a subunit of the G-protein coupled receptor for the neurotransmitter GABA (gamma-aminobutyric acid). It will inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. GABA BR1 is highly expressed in many tissues including eye, atrium, ventricle, lung and colon. In brain, wide expression is seen with high levels in the cerebral cortical layers and hippocampus. Cellularly, it is found at the cell junction, synapse, the postsynaptic cell membrane and cytoplasmic vesicle membrane. Diseases associated with GABBR1 include Temporal Lobe Epilepsy and Persistent Vegetative State.
ICC, IHC, WB
Fusion protein amino acids 873-977 (cytoplasmic C-terminus) of rat GABABR1 (also known as Gamma-aminobutyric acid type B receptor subunit 1, GABA-B receptor 1 and Gb1, accession number Q9Z0U4); Mouse: 98% identity (103/105 amino acids identical); Human: 97% identity (102/105 amino acids identical); Less than 30% identity with GABABR2
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
No cross-reactivity against GABABR1
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
24 months from opening
Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1)