Anti-GABA(B)R1 Antibody (N93A/49)

Name: Anti-GABA(B)R1 Antibody
Brand: NeuroMab
SKU: 75-183
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

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Clonality

Monoclonal

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Gabbr1

Molecular Weight

115 kDa

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Immunoblot versus crude membranes made from adult rat brain (RBM) or GABABR1 wild-type (WT) or knockout (KO) mice probed with N93A/49 (left) or K89/34 (right) TC supe. Mouse brains courtesy of Martin Gassmann and Bernhard Bettler (University of Basel).

Adult rat hippocampus immunohistochemistry.

Immunoblot versus crude membranes made from adult rat brain (RBM) or GABABR1 wild-type (WT) or knockout (KO) mice probed with N93A/49 (left) or K89/34 (right) TC supe. Mouse brains courtesy of Martin Gassmann and Bernhard Bettler (University of Basel).

Product Details

Target

GABA(B)R1

Target Description

Gamma-aminobutyric acid type B receptor subunit 1 or GABA BR1 is encoded by the gene GABBR1. GABA BR1 is a subunit of the G-protein coupled receptor for the neurotransmitter GABA (gamma-aminobutyric acid). It will inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. GABA BR1 is highly expressed in many tissues including eye, atrium, ventricle, lung and colon. In brain, wide expression is seen with high levels in the cerebral cortical layers and hippocampus. Cellularly, it is found at the cell junction, synapse, the postsynaptic cell membrane and cytoplasmic vesicle membrane. Diseases associated with GABBR1 include Temporal Lobe Epilepsy and Persistent Vegetative State.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N93A/49

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Gabbr1

Molecular Weight

115 kDa

Antigen

Fusion protein amino acids 873-977 (cytoplasmic C-terminus) of rat GABABR1 (also known as Gamma-aminobutyric acid type B receptor subunit 1, GABA-B receptor 1 and Gb1, accession number Q9Z0U4); Mouse: 98% identity (103/105 amino acids identical); Human: 97% identity (102/105 amino acids identical); Less than 30% identity with GABABR2

Species Reactivity

Human, Mouse

Antibody Registry ID

AB_2108180

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity against GABABR1

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1)

UniProt Details

UniProt (Human): Q9UBS5
UniProt (Immunogen Species): Q9Z0U4

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Anti-GABA(B)R1 Antibody (N93A/49)

Anti-GABA(B)R1 Antibody
SKU: 75-183

Product Details

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Anti-GABA(B)R1 Antibody (N93A/49)

Anti-GABA(B)R1 Antibody SKU: 75-183

Product Details

Anti-GABA(B)R1 Antibody
SKU: 75-183