Anti-GABA-B-R1 Antibody FL594 Conjugate (N93A/49)

Name: Anti-GABA-B-R1 Antibody FL594 Conjugate
Brand: NeuroMab
SKU: 75-183-FL594
Price: 460.0 USD
Availability: InStock

Our Anti-GABA(B)R1 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N93A/49. It is KO validated, detects human and mouse GABA(B)R1, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Chicken, Human, Mouse, Rabbit, Rat

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

Unconjugated

490

550

650

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Data Sheet

KO Validated

SKU: 75-183-FL594

Volume: 200 µL

Variant

Price:

$460.00

Quantity:

Product Details

Target

GABA(B)R1

Target Description

Gamma-aminobutyric acid type B receptor subunit 1 or GABA BR1 is encoded by the gene GABBR1. GABA BR1 is a subunit of the G-protein coupled receptor for the neurotransmitter GABA (gamma-aminobutyric acid). It will inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. GABA BR1 is highly expressed in many tissues including eye, atrium, ventricle, lung and colon. In brain, wide expression is seen with high levels in the cerebral cortical layers and hippocampus. Cellularly, it is found at the cell junction, synapse, the postsynaptic cell membrane and cytoplasmic vesicle membrane. Diseases associated with GABBR1 include Temporal Lobe Epilepsy and Persistent Vegetative State.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N93A/49

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Gabbr1

Molecular Weight

115 kDa

Antigen

Fusion protein amino acids 873-977 (cytoplasmic C-terminus) of rat GABABR1 (accession number Q9Z0U4) produced recombinantly in E. Coli

Species Reactivity

Chicken, Human, Mouse, Rabbit, Rat

Antibody Registry ID

AB_2939678

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL594 Ex: 594 nm, Em: 615 nm

Specificity

No cross-reactivity against GABABR1

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1)

UniProt Details

UniProt (Human): Q9UBS5
UniProt (Immunogen Species): Q9Z0U4

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Anti-GABA-B-R1 Antibody FL594 Conjugate (N93A/49)

SKU: 75-183-FL594

Product Details

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