Anti-GABA-A-R-Alpha6 Antibody FL650 Conjugate (N229A/32)

Name: Anti-GABA-A-R-Alpha6 Antibody FL650 Conjugate
Brand: NeuroMab
SKU: 75-388-FL650
Price: 486.0 USD
Availability: InStock

Our mouse GABA-A-R-Alpha6 FL650 conjugate monoclonal antibody from NeuroMab is produced in-house from clone N229A/32. It detects mouse and rat GABA-A-R-Alpha6 and is purified by Protein A chromatography. Works in IHC, ICC.

Anti-GABA-A-R-Alpha6 Antibody FL650 Conjugate

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Species Reactivity

Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

Biotin

Carrier-Free

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Data Sheet

SKU: 75-388-FL650

Volume: 200 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

GABA-A-R-Alpha6

Scientific Background

Gamma-aminobutyric acid receptor subunit alpha-6 or GABA-A-R-Alpha6 is encoded by the gene GABRA6. GABAA receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR alpha 5 is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR-Alpha6 is primarily expressed in brain at the cell junction, synapse, the postsynaptic cell membrane and cytoplasmic vesicle membrane. Diseases associated with GABRA6 include neurotic disorder and several forms of epilepsy.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N229A/32

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Gabra6 Gabra-6

Molecular Weight

50 kDa

Immunogen

Fusion protein amino acids 325-420 (last cytoplasmic domain before extracellular C-terminus) of mouse GABA-A-R-Alpha6 (accession number P16305) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2940283

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

Specificity

Does not react with GABA-A-R-Alpha4

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

GABA A; Gamma-aminobutyric acid receptor subunit alpha-6; GABA A Receptor alphα6 polypeptide; GABA(A receptor subunit alpha-6; GABA A receptor alphα6; GABA A receptor subunit alphα6; GABA subunit A receptor alphα6; GABA(A receptor subunit alpha-6; GABRα6; GABRA6; Gamma aminobutyric acid A receptor alphα6; Gamma aminobutyric acid GABA A receptor alphα6; Gamma aminobutyric acid receptor subunit alphα6; Gamma-aminobutyric acid receptor subunit alpha-6; GBRA6_HUMAN; MGC116903; MGC116904

UniProt ID

P16305
UniProt Summary: Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Alpha-6/GABRA6 subunits are found at both synaptic and extrasynaptic sites. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission. Extrasynaptic alpha-6-containing receptors contribute to the tonic GABAergic inhibition. Alpha-6 subunits are also present on glutamatergic synapses.

NCBI Gene ID

14399

Shipping

Shipped on ice packs

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Anti-GABA-A-R-Alpha6 Antibody FL650 Conjugate (N229A/32)

SKU: 75-388-FL650

Product Details

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