Gamma-aminobutyric acid receptor subunit alpha-6 or GABA-A-R-Alpha6 is encoded by the gene GABRA6. GABAA receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR alpha 5 is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR-Alpha6 is primarily expressed in brain at the cell junction, synapse, the postsynaptic cell membrane and cytoplasmic vesicle membrane. Diseases associated with GABRA6 include neurotic disorder and several forms of epilepsy.
ICC, IHC, WB
Fusion protein amino acids 325-420 (last cytoplasmic domain before extracellular C-terminus) of mouse GABA-A-R-Alpha6 (also known as Gamma-aminobutyric acid receptor subunit alpha-6, GABA(A) receptor subunit alpha-6 and Gabra6, accession number P16305); Rat: 91% identity (88/96 amino acids identical); Human: 73% identity (71/96 amino acids identical); 40% identity with GABA-A-R-Alpha4 and other GABA-A receptors
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Does not react with GABA-A-R-Alpha4
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.