Anti-GABA-A-R-Alpha6 Antibody (N229A/32)

Name: Anti-GABA-A-R-Alpha6 Antibody
Brand: NeuroMab
SKU: 75-388
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Clone

N229A/32

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified

Gene Name

Gabra6 Gabra-6

Molecular Weight

50 kDa

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Immunoblot against extracts of COS cells transiently transfected with DsRed-tagged GABAARAlpha4, Flag-tagged GABAARAlpha6 or untagged Kv2.1 plasmid probed with N229A/32 (left), Mouse anti-Flag (middle) or N398A/34 (right) TC supe.

Adult rat brain immunohistochemistry.

Volume: 100 µL

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Product Details

Target

Gamma-aminobutyric acid receptor subunit alpha-6 (GABA(A) receptor subunit alpha-6)

Target Description

Gamma-aminobutyric acid receptor subunit alpha-6 or GABA-A-R-Alpha6 is encoded by the gene GABRA6. GABAA receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR alpha 5 is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR-Alpha6 is primarily expressed in brain at the cell junction, synapse, the postsynaptic cell membrane and cytoplasmic vesicle membrane. Diseases associated with GABRA6 include neurotic disorder and several forms of epilepsy.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N229A/32

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Gabra6 Gabra-6

Molecular Weight

50 kDa

Antigen

Fusion protein amino acids 325-420 (last cytoplasmic domain before extracellular C-terminus) of mouse GABA-A-R-Alpha6 (also known as Gamma-aminobutyric acid receptor subunit alpha-6, GABA(A) receptor subunit alpha-6 and Gabra6, accession number P16305); Rat: 91% identity (88/96 amino acids identical); Human: 73% identity (71/96 amino acids identical); 40% identity with GABA-A-R-Alpha4 and other GABA-A receptors

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2491091

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not react with GABA-A-R-Alpha4

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Gamma-aminobutyric acid receptor subunit alpha-6 (GABA(A) receptor subunit alpha-6)

UniProt Details

UniProt (Human): Q16445
UniProt (Immunogen Species): P16305

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Anti-GABA-A-R-Alpha6 Antibody (N229A/32)

Anti-GABA-A-R-Alpha6 Antibody
SKU: 75-388

Bulk Order Anti-GABA-A-R-Alpha6 Antibody

Product Details

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Anti-GABA-A-R-Alpha6 Antibody (N229A/32)

Anti-GABA-A-R-Alpha6 Antibody SKU: 75-388

Bulk Order Anti-GABA-A-R-Alpha6 Antibody

Product Details

Anti-GABA-A-R-Alpha6 Antibody
SKU: 75-388