Anti-CASPR2 Antibody FL490 Conjugate (K67/25)

Name: Anti-CASPR2 Antibody FL490 Conjugate
Brand: NeuroMab
SKU: 75-075-FL490
Price: 460.0 USD
Availability: InStock

Our Anti-CASPR2 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K67/25. It is KO validated, detects human, mouse, and rat CASPR2, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

Unconjugated

550

594

650

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Data Sheet

KO Validated

SKU: 75-075-FL490

Volume: 200 µL

Variant

Price:

$460.00

Quantity:

Product Details

Target

CASPR2

Target Description

Contactin-associated protein-like 2 protein, or Caspr2, is a neuronal transmembrane member of the Neurexin family. Structural features of Caspr2 include epidermal growth factor repeats, laminin G domains, F5/8 type C domain, fibrinogen-like domains, and PDZ binding sites. Caspr2 is a cell adhesion molecule as well as a receptor. It is involved in mediating cell–cell interactions in the nervous system and involved in neural-glia interactions and clustering of potassium channels in myelinated axons. It is expressed at the juxaperanodal region of nodes of Ranvier in the CNS and PNS. Changes in expression have been associated with increased susceptibility to autism and epilepsy.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

K67/25

Isotype

IgG2a

Applications

ICC, IHC

Host Species

Mouse

Gene Name

CNTNAP2 hCG_15499 tcag7.496

Molecular Weight

180 kDa

Antigen

Fusion protein 96-1265 (extracellular domain) of human Caspr2 (accession number A0A090N7T7) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2939296

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

No cross-reactivity against Caspr/paranodin

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Contactin associated protein-like 2 (Contactin associated protein-like 2, isoform CRA_b)

UniProt Details

UniProt (Human): Q9UHC6
UniProt (Immunogen Species): A0A090N7T7

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Anti-CASPR2 Antibody FL490 Conjugate (K67/25)

SKU: 75-075-FL490

Product Details

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