Contactin-associated protein-like 2 protein, or Caspr2, is a neuronal transmembrane member of the Neurexin family. Structural features of Caspr2 include epidermal growth factor repeats, laminin G domains, F5/8 type C domain, fibrinogen-like domains, and PDZ binding sites. Caspr2 is a cell adhesion molecule as well as a receptor. It is involved in mediating cell–cell interactions in the nervous system and involved in neural-glia interactions and clustering of potassium channels in myelinated axons. It is expressed at the juxaperanodal region of nodes of Ranvier in the CNS and PNS. Changes in expression have been associated with increased susceptibility to autism and epilepsy.
Purified
1 mg/mL
Monoclonal
K67/25
IgG2a
IHC, IP, WB
Mouse
CNTNAP2 hCG_15499 tcag7.496
180 kDa
Fusion protein 96-1265 (extracellular domain) of human Caspr2 (accession number A0A090N7T7); Mouse=94% identity (1105/1171 amino acids identical); Binding site mapped to within a.a. 1124-1265; 97% identical in mouse (138/142 a.a. identical).
Human, Mouse, Rat
AB_2245198
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Unconjugated
No cross-reactivity against Caspr/paranodin
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
![Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)], cerebellum [HBM(Cb)], and hippocampus [HBM(H)].](http://cdn.shopify.com/s/files/1/0014/8806/0475/products/validation-image-73-075-k67-25-wb-2_{width}x.jpg?v=1569646660)
![Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)], cerebellum [HBM(Cb)], and hippocampus [HBM(H)].](http://cdn.shopify.com/s/files/1/0014/8806/0475/products/validation-image-73-075-k67-25-wb-2_1024x.jpg?v=1569646660)