Anti-CASPR2 Antibody (K67/25)
Our Anti-CASPR2 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K67/25. It is KO validated, detects human, mouse, and rat CASPR2, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.
![Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)], cerebellum [HBM(Cb)], and hippocampus [HBM(H)].](http://www.antibodiesinc.com/cdn/shop/files/73-075-k67-25-wb-2_{width}x.jpg?v=1704390077)
Immunoblot on adult rat brain membrane (RBM), and adult mouse brain membranes (MBM) from wild-type (WT) and Caspr2 knockout mice. Caspr KO sample courtesy of Drs. Ido Horresh and Ori Peles, The Weizmann Institute of Science.
![Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)], cerebellum [HBM(Cb)], and hippocampus [HBM(H)].](http://www.antibodiesinc.com/cdn/shop/files/73-075-k67-25-wb-2_1024x.jpg?v=1704390077)
Product Specific References for Applications and Species
- Immunocytochemistry: Human | Mouse | Rat
- Immunohistochemistry: Mouse | Rat
- IPET: Human
- Western Blot: Human | Mouse
| Immunocytochemistry: Human | ||
| PMID | Dilution | Publication |
| 20404108 | not listed | Hsu, C, et al. 2010. Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C. The Journal of cell biology, 223-232. |
| Immunocytochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 25918374 | not listed | Varea, O, et al. 2015. Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons. Proceedings of the National Academy of Sciences of the United States of America, 6176-6181. |
| Immunocytochemistry: Rat | ||
| PMID | Dilution | Publication |
| 21602278 | not listed | Gu. C, et al. 2011. Clustering and activity tuning of Kv1 channels in myelinated hippocampal axons. The Journal of biological chemistry, 25835-25847. |
| Immunohistochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 38194969 | not listed | Miyazaki, Y, et al. 2024. Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity. Cell Reports, 113634. |
| 23842490 | not listed | Koehler, K, et al. 2013. Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture. Nature, 217-221. |
| 22473710 | 1:50 | Irani, S, et al. 2012. Morvan syndrome: clinical and serological observations in 29 cases. Annals of neurology, 241-255. |
| Immunohistochemistry: Rat | ||
| PMID | Dilution | Publication |
| 21734302 | 1:200 | Lysakowski, A, et al. 2011. Molecular microdomains in a sensory terminal, the vestibular calyx ending. The Journal of neuroscience : the official journal of the Society for Neuroscience, 10101-10114. |
| IPET: Human | ||
| PMID | Dilution | Publication |
| 27621318 | 0.005 mg/ml | Lu, Z, et al. 2016. Molecular Architecture of Contactin-associated Protein-like 2 (CNTNAP2) and Its Interaction with Contactin 2 (CNTN2). The Journal of biological chemistry, 24133-24147. |
| Western Blot: Human | ||
| PMID | Dilution | Publication |
| 34921780 | not listed | Martín-de-Saavedra, M, et al. 2021. Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2. Neuron, 627-643. |
| 19706548 | not listed | Ishii, A, et al. 2009. Human myelin proteome and comparative analysis with mouse myelin. Proceedings of the National Academy of Sciences of the United States of America, 1605-14610. |
| Western Blot: Mouse | ||
| PMID | Dilution | Publication |
| 38962061 | not listed | Lobete, M, et al. 2024. A methodology to globally assess ectodomain shedding using soluble fractions from the mouse brain. Frontiers in psychiatry, 1367526. |
| 38194969 | not listed | Miyazaki, Y, et al. 2024. Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity. Cell Reports, 113634. |
| 34921780 | not listed | Martín-de-Saavedra, M, et al. 2021. Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2. Neuron, 627-643. |
| 31262725 | 1:500 | Trotter, J, et al. 2019. Synaptic neurexin-1 assembles into dynamically regulated active zone nanoclusters. The Journal of cell biology, 2677-2698. |
| 27231886 | 1:1000 | Mabb, A, et al. 2016. Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms. PloS one, e0156439. |