Contactin-associated protein-like 2 protein, or Caspr2, is a neuronal transmembrane member of the Neurexin family. Structural features of Caspr2 include epidermal growth factor repeats, laminin G domains, F5/8 type C domain, fibrinogen-like domains, and PDZ binding sites. Caspr2 is a cell adhesion molecule as well as a receptor. It is involved in mediating cell–cell interactions in the nervous system and involved in neural-glia interactions and clustering of potassium channels in myelinated axons. It is expressed at the juxaperanodal region of nodes of Ranvier in the CNS and PNS. Changes in expression have been associated with increased susceptibility to autism and epilepsy.
IHC, IP, WB
CNTNAP2 hCG_15499 tcag7.496
Fusion protein 96-1265 (extracellular domain) of human Caspr2 (accession number A0A090N7T7); Mouse=94% identity (1105/1171 amino acids identical); Binding site mapped to within a.a. 1124-1265; 97% identical in mouse (138/142 a.a. identical).
Human, Mouse, Rat
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