Anti-ASIC1 Antibody (BSA and Azide free) (N271/44)

Name: Anti-ASIC1 Antibody (BSA and Azide free)
Brand: NeuroMab
SKU: 75-277-CF
Price: 486.0 USD
Availability: InStock

Our mouse ASIC1 carrier-free monoclonal antibody from NeuroMab is produced in-house from clone N271/44. It detects mouse and rat ASIC1 and is purified by Protein A chromatography. Works in WB, IHC, ICC, ELISA.

Anti-ASIC1 Antibody (BSA and Azide free)

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Species Reactivity

Mouse, Rat

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Biotin

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Data Sheet

KO Validated

SKU: 75-277-CF

Volume: 100 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

ASIC1

Scientific Background

Acid sensing ion channel 1, Neuronal amiloride-sensitive cation channel 2 or ASIC1 is encoded by the gene ASIC1 and is a member of the Acid sensing ion channel (ASIC) family. ASIC1 acts as an acid sensing proton gated sodium channel and is thought to play a role in learning, pain transduction, memory development, and fear conditioning. ASIC1 is widely expressed in the central and peripheral nervous system. Diseases associated with ASIC1 include spatial learning and memory capability problems and Frozen Shoulder.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.6-1.0 mg/mL

Clonality

Monoclonal

Clone

N271/44

Isotype

IgG1

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

Asic1 Accn2 Asic Bnac2

Molecular Weight

60 kDa

Immunogen

Fusion protein amino acids 460-526 (cytoplasmic C-terminus) of mouse ASIC1 (accession number Q6NXK8) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and buffer exchanged into 1X PBS. Purified mAbs are >90% specific antibody.

Buffer

PBS

Conjugate

Unconjugated

Specificity

Does not cross-react with ASIC2

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

AI843610; Acid-sensing ion channel 1; ASIC1a; ASIC1; Accn2; Acid-sensing ion channel; B530003N02Rik; Amiloride-sensitive cation channel 2; BNaC2; Brain sodium channel 2; neuronal; degenerin 2

UniProt ID

Q6NXK8
UniProt Summary: Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory. Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents. Displays high selectivity for sodium ions but can also permit the permeation of other cations. Regulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines. Modulates neuronal activity in the circuits underlying innate fear.

NCBI Gene ID

11419

Shipping

Shipped on ice packs

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Anti-ASIC1 Antibody (BSA and Azide free) (N271/44)

SKU: 75-277-CF

Product Details

Bulk Order Anti-ASIC1 Antibody (BSA and Azide free)

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